Trial · NCT07541378
Comparative Efficacy of Once-daily LAMA/LABA Combinations Versus Tiotropium on Constant-work-rate Cycle Endurance in COPD
NCT07541378, Not applicable, Suspended, Medical University of Bialystok
3 sourcestrials-2026-11-12-0.4.0
Cite this record
ConductScience Library. Comparative Efficacy of Once-daily LAMA/LABA Combinations Versus Tiotropium on Constant-work-rate Cycle Endurance in COPD. Trials, record NCT07541378. Release trials-2026-11-12-0.4.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT07541378
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- Comparative Efficacy of Once-daily LAMA/LABA Combinations Versus Tiotropium on Constant-work-rate Cycle Endurance in COPD
- NCT number
- NCT07541378
- Status
- Suspended
- Phases
- Not applicable
- Enrollment
- 100 participants, estimated
- Lead sponsor
- Medical University of Bialystok
- Conditions
- COPD (Chronic Obstructive Pulmonary Disease)
- Interventions
- Tiotropium, Olodaterol, Umeclidinium, Vilanterol, Indacaterol, Glycopyrronium
- First posted
- 2026-04-21
- Last updated
- 2026-10-02
Source ClinicalTrials.gov
Registered outcomes20
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Endurance time during constant-work-rate cycle ergometry (CWRCE) | Baseline and after 28 days of each treatment period | Change in endurance time (ET) during constant-work-rate exercise testing at 80% peak workload, measured by cardiopulmonary exercise testing (CPET). |
| Secondary | Peak oxygen uptake (VO₂peak) during CPET | Baseline and after 28 days of each treatment period | Change in peak oxygen uptake measured during cardiopulmonary exercise testing (CPET). |
| Secondary | Oxygen uptake (VO₂) at isotime during CPET | Baseline and after 28 days of each treatment period | Change in oxygen uptake at isotime measured during cardiopulmonary exercise testing (CPET). |
| Secondary | Forced expiratory volume in 1 second (FEV₁) | Baseline and after 28 days of each treatment period | Change in forced expiratory volume in 1 second (FEV₁). |
| Secondary | Forced vital capacity (FVC) | Baseline and after 28 days of each treatment period | Change in forced vital capacity (FVC). |
| Secondary | Inspiratory capacity at rest during CPET | Baseline and after 28 days of each treatment period | Change in inspiratory capacity at rest measured during cardiopulmonary exercise testing (CPET). |
| Secondary | Inspiratory capacity at isotime during CPET | Baseline and after 28 days of each treatment period | Change in inspiratory capacity at isotime measured during cardiopulmonary exercise testing (CPET). |
| Secondary | Inspiratory capacity at peak exercise during CPET | Baseline and after 28 days of each treatment period | Change in inspiratory capacity at peak exercise measured during cardiopulmonary exercise testing (CPET). |
| Secondary | St. George's Respiratory Questionnaire (SGRQ) total score | Baseline and after 28 days of each treatment period | Change in St. George's Respiratory Questionnaire (SGRQ) total score. Scores range from 0 to 100, with lower scores indicating better health-related quality of life and higher scores indicating worse health-related quality of life. |
| Secondary | Dyspnoea intensity at isotime measured by the Modified Borg Dyspnoea Scale | Baseline and after 28 days of each treatment period | Change in dyspnoea intensity at isotime measured by the Modified Borg Dyspnoea Scale. Scores range from 0 to 10, with lower scores indicating less dyspnoea and higher scores indicating more severe dyspnoea. |
1 to 10 of 20Source ClinicalTrials.gov
See all 20 registered outcomesOutcomes0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
None in this release.
Results by group0
Each measurement the trial posted, group by group, in the words and numbers it posted.
None in this release.
Participant flow0
How many started, completed or left each group, period by period.
None in this release.
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals0
The totals the trial posted for each group.
None in this release.
Papers3
The papers the trial lists on ClinicalTrials.gov.
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Source
- Release
- trials-2026-11-12-0.4.0
- Release manifest SHA-256
- 0f4a8d8c48aee2a7573ae0fa94ecbeab70c1adbe449bbc95c424bc7d3e97b9d4
- Registry capture
- 2026-11-12
- Results copy, AACT
- 2026-03-23
- NIH clinical studies file
- 2026-11-13
Source ClinicalTrials.gov
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNone stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT07541378
GET https://conductscience.org/api/trials/v1/NCT07541378/registered