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Trial · NCT07557498

Registered outcomes24

Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.

ListOutcomeTime frameDescription
PrimaryParticipant blood pressure (both systolic and diastolic)BaselineGroup 1 only
PrimaryDate of diagnosis of hypertrophic cardiomyopathyBaselineGroup 1 only
PrimaryHypertrophic cardiomyopathy genetic testing resultsBaselineGroup 1 only
PrimaryFamily history of hypertrophic cardiomyopathyBaselineGroup 1 only
PrimaryFamily history of Sudden Cardiac Death (SCD)BaselineGroup 1 only
PrimaryParticipant comorbidities (cardiovascular and non-cardiovascular )BaselineGroup 1 only
PrimaryType of prior surgeries and proceduresBaseline and up to week 24
Group 1 only. Prior surgeries and procedures include: Septal Reduction Therapy (SRT), surgeries (valve repair/placement, left atrial appendage ligation), placement of devices (Implantable Cardioverter Defibrillator (ICD), pacemaker and cardiac resynchronization therapy) or atrial fibrillation/flutter ablation
PrimaryParticipant New York Heart Association (NYHA) class categoryBaseline, and at weeks 4, 8, 12, 24Group 1 only
PrimaryChange in participant New York Heart Association (NYHA) class from baselineBaseline, and at weeks 4, 8, 12, 24Group 1 only
PrimaryDuration of mavacamten treatmentBaseline, and at weeks 4, 8, 12, 24Group 1 only
PrimaryNumber of mavacamten dose titrationsBaseline, and at weeks 4, 8, 12, 24Group 1 only
PrimaryType of mavacamten dose tritrationBaseline, and at weeks 4, 8, 12, 24Group 1 only
PrimaryClinical reason for mavacamten dose titrationBaseline, and at weeks 4, 8, 12, 24Group 1 only
PrimaryClinical reason for mavacamten treatment discontinuationBaseline, and at weeks 4, 8, 12, 24Group 1 only
PrimaryLeft Ventricular Ejection Fraction (LVEF) recovery after mavacamten discontinuation if discontinued due to LVEF<50%,Baseline, and at weeks 4, 8, 12, 24Group 1 only
PrimaryTime from mavacamten discontinuation to Left Ventricular Ejection Fraction (LVEF) recoveryBaseline, and at weeks 4, 8, 12, 24Group 1 only
PrimaryClinical reason for temporary mavacamten treatment interuptionBaseline, and at weeks 4, 8, 12, 24Group 1 only
PrimaryTime to temporary mavacamten treatment interruptionBaseline, and at weeks 4, 8, 12, 24Group 1 only
PrimaryLeft Ventricular Ejection Fraction (LVEF) recovery after mavacamten interruption if the interruption was due to LVEF<50%Baseline, and at weeks 4, 8, 12, 24Group 1 only
PrimaryTime from mavacamten treatment interruption to Left Ventricular Ejection Fraction (LVEF) recoveryBaseline, and at weeks 4, 8, 12, 24Group 1 only

Source ClinicalTrials.govtrials-2026-11-12-0.4.0

Sources 3

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ClinicalTrials.govNone stated
  • NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ClinicalTrials.govnone stated
  • NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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