Trial · NCT07571681
Colchicine for Autoimmune and Subacute Thyroiditis
NCT07571681, Phase 2, Phase 3, Recruiting, Mansoura University
3 sourcestrials-2026-11-12-0.4.0
Cite this record
ConductScience Library. Colchicine for Autoimmune and Subacute Thyroiditis. Trials, record NCT07571681. Release trials-2026-11-12-0.4.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT07571681
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- Colchicine for Autoimmune and Subacute Thyroiditis
- NCT number
- NCT07571681
- Status
- Recruiting
- Phases
- Phase 2, Phase 3
- Enrollment
- 300 participants, estimated
- Lead sponsor
- Mansoura University
- Conditions
- Hashimoto Thyroiditis, Subacute Thyroiditis, Thyroiditis
- Interventions
- colchicine, Prednisolone, NSAID
- First posted
- 2026-05-06
- Last updated
- 2026-07-29
Source ClinicalTrials.gov
Registered outcomes10
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Mean Change in C-Reactive Protein (CRP) | Baseline, Month 3, Month 6 | Reduction in serum C-reactive protein concentration compared with baseline among treatment groups. |
| Primary | Mean Change in Erythrocyte Sedimentation Rate (ESR) | Baseline, Month 3, Month 6 | Reduction in erythrocyte sedimentation rate compared with baseline among treatment groups. |
| Primary | Mean Change in Thyroid Pain and Inflammatory Symptom from Baseline | Baseline, Month 1, Month 3, Month 6 | Improvement in thyroid pain, neck tenderness, local discomfort, and inflammatory symptoms will be assessed using a standardized Thyroid Pain and Inflammatory Symptom Score ranging from 0 to 10, where higher scores indicate greater symptom severity and lower scores indicate clinical improvement. |
| Secondary | Mean Change in Serum Thyroid-Stimulating Hormone (TSH) Concentration from Baseline | Baseline, Month 3, Month 6 | Assessment of changes in serum thyroid-stimulating hormone (TSH) concentrations compared with baseline values. |
| Secondary | Mean Change in Serum Free Triiodothyronine (Free T3) and Free Thyroxine (Free T4) Levels from Baseline | Baseline, Month 3, Month 6 | Assessment of changes in serum free triiodothyronine (Free T3) and free thyroxine (Free T4) concentrations compared with baseline values. |
| Secondary | Mean Change in Serum Thyroid Peroxidase Antibody (TPOAb) and Thyroglobulin Antibody (TgAb) Levels from Baseline | Baseline, Month 6 | Assessment of changes in serum thyroid peroxidase antibody (TPOAb) and thyroglobulin antibody (TgAb) concentrations to evaluate autoimmune inflammatory activity. |
| Secondary | Change in Thyroid Ultrasound Inflammatory Findings from Baseline | Baseline, Month 6 | Assessment of changes in thyroid ultrasound characteristics, including gland vascularity, parenchymal heterogeneity, gland enlargement, and inflammatory changes compared with baseline findings. |
| Secondary | Recurrence Rate of Thyroiditis | Any recurrence during 6-month follow-up | Number and proportion of participants experiencing clinical or biochemical recurrence of thyroiditis after initial improvement during follow-up. |
| Secondary | Need for Rescue Corticosteroid Therapy | Throughout 6-month follow-up | Number and proportion of participants requiring rescue corticosteroid treatment because of persistent symptoms, worsening inflammation, or inadequate clinical response. |
| Secondary | Adverse Events / Drug Intolerance | Baseline to Month 6 | Frequency, type, and severity of adverse events or treatment intolerance including gastrointestinal symptoms, hepatic dysfunction, renal impairment, cytopenia, or steroid-related adverse effects. |
Source ClinicalTrials.gov
Outcomes0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
None in this release.
Results by group0
Each measurement the trial posted, group by group, in the words and numbers it posted.
None in this release.
Participant flow0
How many started, completed or left each group, period by period.
None in this release.
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals0
The totals the trial posted for each group.
None in this release.
Papers3
The papers the trial lists on ClinicalTrials.gov.
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Source
- Release
- trials-2026-11-12-0.4.0
- Release manifest SHA-256
- 0f4a8d8c48aee2a7573ae0fa94ecbeab70c1adbe449bbc95c424bc7d3e97b9d4
- Registry capture
- 2026-11-12
- Results copy, AACT
- 2026-03-23
- NIH clinical studies file
- 2026-11-13
Source ClinicalTrials.gov
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNone stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT07571681
GET https://conductscience.org/api/trials/v1/NCT07571681/registered