Early Cognitive Changes After Same-day Discharge Hip and Knee Arthroplasty
NCT07598552, Recruiting, Odense University Hospital
Trial 8
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
| Field | Value | Source |
|---|---|---|
| Title | Early Cognitive Changes After Same-day Discharge Hip and Knee Arthroplasty | ClinicalTrials.gov |
| NCT number | NCT07598552 | ClinicalTrials.gov |
| Status | Recruiting | ClinicalTrials.gov |
| Enrollment | 48 participants, estimated | ClinicalTrials.gov |
| Lead sponsor | Odense University Hospital | ClinicalTrials.gov |
| Conditions | Postoperative Cognitive Dysfunction (POCD), Cognitive Change, Total Knee Arthroplasty, Unicompartmental Knee Arthroplasty | ClinicalTrials.gov |
| First posted | 2026-05-20 | ClinicalTrials.gov |
| Last updated | 2026-06-22 | ClinicalTrials.gov |
Registered outcomes 12
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description | Source |
|---|---|---|---|---|
| Primary | Change in Symbol Digit Modalities Test (SDMT) score from baseline to postoperative day 1. | From baseline, 14 days before surgery, and postoperative day 1. | The SDMT is a validated neuropsychological tool that measures processing speed, attention, and visual scanning. The SDMT will be administered virtually as an oral 90-second test. The primary metric will be the SDMT score, defined as the number of correct digit substitutions completed within 90 seconds | ClinicalTrials.gov |
| Secondary | Change in Symbol Digit Modalities Test (SDMT) score from baseline to postoperative day 7. | From baseline, 14 days before surgery, and postoperative day 7. | The SDMT is a validated neuropsychological tool that measures processing speed, attention, and visual scanning. The SDMT will be administered virtually as an oral 90-second test. The primary metric will be the SDMT score, defined as the number of correct digit substitutions completed within 90 seconds | ClinicalTrials.gov |
| Secondary | Change in Stroop Color-Word Test score from baseline to postoperative day 1. | From baseline, 14 days before surgery, and postoperative day 1. | The Stroop Color-Word Test is a validated measure of selective attention and susceptibility to interference. The primary metrics will be completion time (seconds) and number of errors recorded for each session. | ClinicalTrials.gov |
| Secondary | Change in Stroop Color-Word Test score from baseline to postoperative day 7. | From baseline, 14 days before surgery, and postoperative day 7. | The Stroop Color-Word Test is a validated measure of selective attention and susceptibility to interference. The primary metrics will be completion time (seconds) and number of errors recorded for each session. | ClinicalTrials.gov |
| Secondary | Change in Verbal fluency assessment score from baseline to postoperative day 1. | From baseline, 14 days before surgery, and postoperative day 1. | Verbal fluency assessment is a validated test which assesses executive function, semantic memory, and language. In our test a semantic (animal naming) and a phonemic (letter S) fluency task were used, each administered for 60 seconds. Number of correct responses for each task will be registered. | ClinicalTrials.gov |
| Secondary | Change in Verbal fluency assessment score from baseline to postoperative day 7. | From baseline, 14 days before surgery, and postoperative day 7. | Verbal fluency assessment is a validated test which assesses executive function, semantic memory, and language. In our test a semantic (animal naming) and a phonemic (letter S) fluency task were used, each administered for 60 seconds. Number of correct responses for each task will be registered. | ClinicalTrials.gov |
| Secondary | Reporting patient-reported cognitive function on postoperative day 1. | Postoperative day 1. | A brief two-item subjective cognitive questionnaire will be administered to assess patient's perceived cognitive changes and to identify any discrepancy between subjective experience and objective neuropsychological test performance. | ClinicalTrials.gov |
| Secondary | Change in patient-reported cognitive function from postoperative day 1 to postoperative day 7. | From postoperative day 1 and postoperative day 7. | A brief two-item subjective cognitive questionnaire will be administered to assess patient's perceived cognitive changes and to identify any discrepancy between subjective experience and objective neuropsychological test performance. | ClinicalTrials.gov |
| Other | Cumulative In-hospital postoperative morphine consumption | End of surgery until discharge from the hospital on the day 1 of surgery (DOS) | Measured in milligrams | ClinicalTrials.gov |
| Other | Cumulative postoperative morphine consumption | Postoperative day 1 to postoperative day 7. | Measured in milligrams. | ClinicalTrials.gov |
| Other | Postoperative pain intensity during rest once a day. | From postoperative day 1 to postoperative day 7. | Patients will record pain intensity using an 11-point numeric rating scale (NRS, 0-10) in a pain diary. | ClinicalTrials.gov |
| Other | Postoperative pain intensity during activity once a day | From postoperative day 1 to postoperative day 7. | Patients will record pain intensity using an 11-point numeric rating scale (NRS, 0-10) in a pain diary. Pain will be assessed defined as a standardized 5-m walk test. | ClinicalTrials.gov |
Outcomes 0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
| Type | Outcome | Time frame | Population | Units | Measured as | Source |
|---|
Results by group 0
Each measurement the trial posted, group by group, in the words and numbers it posted.
| Outcome | Group | Category | Value | Spread | Units | Source |
|---|
Participant flow 0
How many started, completed or left each group, period by period.
| Period | Milestone | Group | Participants | Units counted | Source |
|---|
Adverse events 0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
| Type | Event | Organ system | Group | Affected | At risk | Events | Source |
|---|
Adverse event totals 0
The totals the trial posted for each group.
| Total | Group | Affected | At risk | Source |
|---|
Papers 23
The papers the trial lists on ClinicalTrials.gov.
| PMID | Listed as | Source |
|---|---|---|
| 18929686 | BACKGROUND | PubMed |
| 20830649 | BACKGROUND | PubMed |
| 22277666 | BACKGROUND | PubMed |
| 22831887 | BACKGROUND | PubMed |
| 23013462 | BACKGROUND | PubMed |
| 23541866 | BACKGROUND | PubMed |
| 24939863 | BACKGROUND | PubMed |
| 29577228 | BACKGROUND | PubMed |
| 30588700 | BACKGROUND | PubMed |
| 31008923 | BACKGROUND | PubMed |
| 33143651 | BACKGROUND | PubMed |
| 34039195 | BACKGROUND | PubMed |
| 34923428 | BACKGROUND | PubMed |
| 35919025 | BACKGROUND | PubMed |
| 36942664 | BACKGROUND | PubMed |
| 37599617 | BACKGROUND | PubMed |
| 38134323 | BACKGROUND | PubMed |
| 38444430 | BACKGROUND | PubMed |
| 38839429 | BACKGROUND | PubMed |
| 39045891 | BACKGROUND | PubMed |
Grants 0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
| Project | Title | Principal investigators | Organization | Funder | Fiscal years | Source |
|---|
Trial comparisons 0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
| Comparison | Source |
|---|
Tests 4
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
| Test | Named as | Source |
|---|---|---|
| Symbol Coding | Primary outcome | ConductCognition |
| Category Fluency | Secondary outcome | ConductCognition |
| Stroop Color-Word Test | Secondary outcome | ConductCognition |
| Verbal Fluency | Secondary outcome | ConductCognition |
Source 5
| Field | Value | Source |
|---|---|---|
| Release | trials-2026-11-12-0.4.0 | ClinicalTrials.gov |
| Release manifest SHA-256 | 0f4a8d8c48aee2a7573ae0fa94ecbeab70c1adbe449bbc95c424bc7d3e97b9d4 | ClinicalTrials.gov |
| Registry capture | 2026-11-12 | ClinicalTrials.gov |
| Results copy, AACT | 2026-03-23 | ClinicalTrials.gov |
| NIH clinical studies file | 2026-11-13 | ClinicalTrials.gov |
Release trials-2026-11-12-0.4.0
ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
NIH RePORTER's clinical studies and project files: Public domain (NIH RePORTER)