Trial · NCT07606664
Fezolinetant and Vascular Health and Brain Health
NCT07606664, Phase 3, Not yet recruiting, Rebecca Thurston
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. Fezolinetant and Vascular Health and Brain Health. Trials, record NCT07606664. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT07606664
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- Fezolinetant and Vascular Health and Brain Health
- NCT number
- NCT07606664
- Status
- Not yet recruiting
- Phases
- Phase 3
- Enrollment
- 220 participants, estimated
- Lead sponsor
- Rebecca Thurston
- Conditions
- Menopause Hot Flashes
- Interventions
- Placebo, Fezolinetant
- First posted
- 2026-05-26
- Last updated
- 2026-08-19
Source ClinicalTrials.gov
Registered outcomes8
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Flow-Mediated Dilation | Baseline and end of treatment at 12 weeks. | Endothelial function assessed by flow-mediated dilation |
| Primary | Verbal Memory Performance | Baseline and end of treatment at 12 weeks. | Verbal memory performance on the California Verbal Learning Test |
| Secondary | Endothelial Biomarkers | Baseline and end of treatment at 12 weeks. | Blood-based endothelial function biomarkers |
| Secondary | Brain Activation during Verbal Encoding | Baseline and end of treatment at 12 weeks. | Memory circuitry as measured by changes in brain activation during performance of a functional magnetic resonance imaging (fMRI) task of verbal encoding |
| Secondary | Functional Connectivity during recall | Baseline and end of treatment at 12 weeks. | Memory circuitry as measured by changes in functional connectivity during performance of a functional magnetic resonance imaging (fMRI) task of verbal recall |
| Secondary | Subjective Vasomotor Hot Flash Diary | Baseline and end of treatment at 12 weeks. | frequency of subjectively assessed VMS using a digital hot flash diary |
| Secondary | Objective Vasomotor Monitoring | Baseline and end of treatment at 12 weeks. | Frequency of objectively measured VMS using 24-hour skin conductance monitoring |
| Secondary | Sleep Monitoring | Baseline and end of treatment at 12 weeks. | Objective sleep monitoring. |
Source ClinicalTrials.gov
Outcomes0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
None in this release.
Results by group0
Each measurement the trial posted, group by group, in the words and numbers it posted.
None in this release.
Participant flow0
How many started, completed or left each group, period by period.
None in this release.
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals0
The totals the trial posted for each group.
None in this release.
Papers0
The papers the trial lists on ClinicalTrials.gov.
None in this release.
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests1
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
| Test | Named as |
|---|---|
| Verbal Learning | Primary outcome |
Source ConductCognition
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT07606664
GET https://conductscience.org/api/trials/v1/NCT07606664/registered