Multimodal Study About Absence of Dp140 in Becker Muscular Dystrophy: Brain-muscle Imaging, Cognition and Muscle Function
NCT07740057, Not yet recruiting, Institut de Myologie, France
Trial 8
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
| Field | Value | Source |
|---|---|---|
| Title | Multimodal Study About Absence of Dp140 in Becker Muscular Dystrophy: Brain-muscle Imaging, Cognition and Muscle Function | ClinicalTrials.gov |
| NCT number | NCT07740057 | ClinicalTrials.gov |
| Status | Not yet recruiting | ClinicalTrials.gov |
| Enrollment | 75 participants, estimated | ClinicalTrials.gov |
| Lead sponsor | Institut de Myologie, France | ClinicalTrials.gov |
| Conditions | Becker Muscular Dystrophy | ClinicalTrials.gov |
| First posted | 2026-07-31 | ClinicalTrials.gov |
| Last updated | 2026-11-03 | ClinicalTrials.gov |
Registered outcomes 32
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description | Source |
|---|---|---|---|---|
| Primary | Brain volume | 2 years | Measurement of grey and white matter volume (in mm3) using brain MRI sequences. | ClinicalTrials.gov |
| Primary | Brain cortical thickness | 2 years | Measurement of cortical thickness (in mm) using brain MRI sequences. | ClinicalTrials.gov |
| Primary | Brain water motion | 2 years | Measurement of diffusion-based values, including apparent diffusion coefficient (in m2/s) and fractional anisotropy (unitless) using diffusion-weighted MRI sequences. | ClinicalTrials.gov |
| Primary | Brain iron metabolism | 2 years | Measurement of brain iron metabolism using MRI-based quantitative susceptibility mapping (measured in parts per million). | ClinicalTrials.gov |
| Primary | Brain function: resting-state and following task | 2 years | Measurement of resting-state brain function (default-mode-network) using functional MRI. Measurement of brain activation using fMRI following fronto-executive task (Stroop test). | ClinicalTrials.gov |
| Primary | Intelligence test | 2 years | Evaluation of intelligence using Wechsler Scale of Intelligence (WAIS-4). | ClinicalTrials.gov |
| Primary | Psychological evaluation of depression | 2 years | Psychological evaluation using Beck Depression Inventory-II (BDI-II). | ClinicalTrials.gov |
| Primary | Psychological evaluation of anxiety | 2 years | Psychological evaluation using State-Trait Anxiety Inventory-2 (STAI-Y2). | ClinicalTrials.gov |
| Primary | Psychological evaluation of ADHD | 2 years | Psychological evaluation using Connors Adult Rating Scale. | ClinicalTrials.gov |
| Primary | Neuropsychological evaluation of memory for attention and cognitive processing | 2 years | Neuropsychological cognitive evaluation of memory for attention and cognitive processing using Free and Cued Selective Reminding Test (FCSRT). | ClinicalTrials.gov |
| Primary | Neuropsychological evaluation of visual memory and executive function | 2 years | Neuropsychological cognitive evaluation of visual memory and executive function using Rey-Osterrieth Complex Figure Test (ROCF). | ClinicalTrials.gov |
| Primary | Neuropsychological evaluation of visual attention and task switching | 2 years | Neuropsychological cognitive evaluation of visual attention and task switching using Trail Making Test. | ClinicalTrials.gov |
| Primary | Neuropsychological evaluation of inhibition | 2 years | Neuropsychological cognitive evaluation of inhibition using Stroop Color and Word Test. | ClinicalTrials.gov |
| Primary | Neuropsychological evaluation of verbal functioning | 2 years | Neuropsychological cognitive evaluation of verbal functioning using Phonemic verbal fluency test. | ClinicalTrials.gov |
| Primary | Neuropsychological evaluation of facial expressions. | 2 years | Neuropsychological cognitive evaluation of facial expressions using Pictures of Facial Affect test. | ClinicalTrials.gov |
| Primary | Neuropsychological evaluation of empathy | 2 years | Neuropsychological cognitive evaluation understanding inappropriateness, speaker's intentions/motivations, speaker's belief, empathy (participant's ability to know how the character would feel), and finally story comprehension using Faux pas Recognition Test. Empathy is also evaluated using The Interpersonal Reactivity Index. | ClinicalTrials.gov |
| Secondary | Evaluation of muscle disease progression | 2 years | Evaluation of disease progression based on quantitative assessment of MRI-based muscle fat fraction (FF, in %) and residual muscle (i.e. contractile cross-sectional area, in cm2) in lower limb (individual thigh and leg muscles). | ClinicalTrials.gov |
| Secondary | Evaluation of muscle disease activity (edema, inflammation, ...) | 2 years | Evaluation of qMRI-biomarkers sensitive to active muscle damage or disease activity such as water T2 and water T1 mapping, expressed in milliseconds (individual thigh and leg muscles). | ClinicalTrials.gov |
| Secondary | Evaluation of muscle extracellular volume | 2 years | Evaluation of extracellular volume (ECV) in muscle (unitless or %) will be assessed using qMRI-based T1 mapping before and after contrast agent injection (individual thigh and leg muscles). | ClinicalTrials.gov |
| Secondary | Evaluation of energy metabolism. | 2 years | Evaluation of energy metabolism using qMRI and 31P magnetic resonance spectroscopy. | ClinicalTrials.gov |
Outcomes 0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
| Type | Outcome | Time frame | Population | Units | Measured as | Source |
|---|
Results by group 0
Each measurement the trial posted, group by group, in the words and numbers it posted.
| Outcome | Group | Category | Value | Spread | Units | Source |
|---|
Participant flow 0
How many started, completed or left each group, period by period.
| Period | Milestone | Group | Participants | Units counted | Source |
|---|
Adverse events 0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
| Type | Event | Organ system | Group | Affected | At risk | Events | Source |
|---|
Adverse event totals 0
The totals the trial posted for each group.
| Total | Group | Affected | At risk | Source |
|---|
Papers 0
The papers the trial lists on ClinicalTrials.gov.
| PMID | Listed as | Source |
|---|
Grants 0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
| Project | Title | Principal investigators | Organization | Funder | Fiscal years | Source |
|---|
Trial comparisons 0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
| Comparison | Source |
|---|
Tests 8
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
| Test | Named as | Source |
|---|---|---|
| Complex Figure Copy and Recall | Primary outcome | ConductCognition |
| Selective Reminding Task | Primary outcome | ConductCognition |
| Social Slips Stories Task | Primary outcome | ConductCognition |
| Stroop Color-Word Test | Primary outcome | ConductCognition |
| Task Switching Test | Primary outcome | ConductCognition |
| Trail Making Test A | Primary outcome | ConductCognition |
| Trail Making Test B | Primary outcome | ConductCognition |
| Verbal Fluency | Primary outcome | ConductCognition |
Source 5
| Field | Value | Source |
|---|---|---|
| Release | trials-2026-11-12-0.4.0 | ClinicalTrials.gov |
| Release manifest SHA-256 | 0f4a8d8c48aee2a7573ae0fa94ecbeab70c1adbe449bbc95c424bc7d3e97b9d4 | ClinicalTrials.gov |
| Registry capture | 2026-11-12 | ClinicalTrials.gov |
| Results copy, AACT | 2026-03-23 | ClinicalTrials.gov |
| NIH clinical studies file | 2026-11-13 | ClinicalTrials.gov |
Release trials-2026-11-12-0.4.0
ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
NIH RePORTER's clinical studies and project files: Public domain (NIH RePORTER)