LLM-Driven Daily Conversation for Cognitive Health in Older Adults
NCT07751510, Not applicable, Not yet recruiting, Taipei Medical University Shuang Ho Hospital
Trial 10
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
| Field | Value | Source |
|---|---|---|
| Title | LLM-Driven Daily Conversation for Cognitive Health in Older Adults | ClinicalTrials.gov |
| NCT number | NCT07751510 | ClinicalTrials.gov |
| Status | Not yet recruiting | ClinicalTrials.gov |
| Phases | Not applicable | ClinicalTrials.gov |
| Enrollment | 75 participants, estimated | ClinicalTrials.gov |
| Lead sponsor | Taipei Medical University Shuang Ho Hospital | ClinicalTrials.gov |
| Conditions | Subjective Cognitive Decline | ClinicalTrials.gov |
| Interventions | LLM Conversation Cognitive Interaction, Interest-Based Knowledge Reading, Waitlist Health Education | ClinicalTrials.gov |
| First posted | 2026-08-07 | ClinicalTrials.gov |
| Last updated | 2026-08-07 | ClinicalTrials.gov |
Registered outcomes 14
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description | Source |
|---|---|---|---|---|
| Primary | Verbal fluency test | Change from Baseline at 13 weeks | The Verbal Fluency Test assesses language production and executive function. Participants will name as many items as possible from specified semantic categories, including fruits and vegetables, within 60 seconds. The outcome is the number of correct, non-repeated words produced. Higher scores indicate better verbal fluency. The primary outcome will be the change in the total number of correct words from baseline to the post-intervention assessment. | ClinicalTrials.gov |
| Primary | Chinese Verbal Learning Test | Change from Baseline at 13 weeks | The Chinese Version Verbal Learning Test assesses verbal learning and memory. A list of 9 two-character nouns is presented across 4 learning trials. After each trial, participants recall as many words as possible. One point is given for each correctly recalled word. The total learning score is the sum of correct responses across the 4 learning trials and ranges from 0 to 36. Higher scores indicate better verbal learning. The primary outcome will be the change in the total learning score from baseline to the post-intervention assessment. | ClinicalTrials.gov |
| Secondary | Digit Span subtest | Change from Baseline at 13 weeks | The Digit Span test assesses verbal attention, short-term memory, and working memory. It includes forward and backward digit span tasks. Each correctly repeated sequence receives 1 point. The forward and backward raw scores are added to produce a total score ranging from 0 to 32. Higher scores indicate better verbal attention and working memory. The outcome will be the change in total score from baseline to the post-intervention assessment. | ClinicalTrials.gov |
| Secondary | Cookie Theft Picture | Change from Baseline at 13 weeks | The Cookie Theft Picture is a well-known visual stimulus used to assess language comprehension and expressive language abilities. The picture shows a mother washing dishes beside a kitchen sink while the water is overflowing. Two children are standing on a stool and attempting to take cookies from a cupboard. While the participant describes the scene, the assessor evaluates language production, including grammatical structure, word choice, speech fluency, and syntactic errors. The participant is shown the picture and instructed, "Please tell me as completely as possible what is happening in this picture." The task ends when the participant indicates that the description is complete or stops speaking for more than 10 to 15 seconds. | ClinicalTrials.gov |
| Secondary | Digit Symbol Substitution Test | Change from Baseline at 13 weeks | The Digit Symbol Substitution Test assesses attention and information processing speed. Participants use a key to match numbers with corresponding symbols and complete as many items as possible within 90 seconds. The score is the number of correctly completed items. Higher scores indicate better attention and processing speed. The outcome will be the change in score from baseline to the post-intervention assessment. | ClinicalTrials.gov |
| Secondary | Stroop Color and Word Test | Change from Baseline at 13 weeks | The Stroop Color and Word Test assesses selective attention and inhibitory control. In the incongruent condition, participants identify the ink color while ignoring the meaning of the printed word. The score is the number of correct responses completed within the specified test period. Higher scores indicate better selective attention and inhibitory control. The outcome will be the change in score from baseline to the post-intervention assessment. | ClinicalTrials.gov |
| Secondary | Color Trails Test | Change from Baseline at 13 weeks | The Color Trails Test Part 1 assesses visual attention and information processing speed. Participants connect numbered circles from 1 to 25 in ascending order as quickly as possible. The outcome is the completion time measured in seconds. Lower completion times indicate better performance. The outcome will be the change in completion time from baseline to the post-intervention assessment. The Color Trails Test Part 2 assesses complex attention, cognitive flexibility, and executive function. Participants connect numbered circles in ascending order while alternating between 2 colors. The outcome is the completion time measured in seconds. Lower completion times indicate better performance. The outcome will be the change in completion time from baseline to the post-intervention assessment. | ClinicalTrials.gov |
| Secondary | Theory of Mind Scale | Change from Baseline at 13 weeks | The Theory of Mind Scale assesses the ability to understand other people's thoughts, intentions, and emotions. It includes a verbal task scored from 0 to 30 and a nonverbal picture task scored from 0 to 20. The scores are added to produce a total score ranging from 0 to 50. Higher scores indicate better theory of mind ability. The outcome will be the change in total score from baseline to the post-intervention assessment. | ClinicalTrials.gov |
| Secondary | Geriatric Depression Scale- 15 | Change from Baseline at 13 weeks | The 15-item Geriatric Depression Scale assesses depressive symptoms in older adults. Each item is scored as 0 or 1, producing a total score ranging from 0 to 15. Higher scores indicate more severe depressive symptoms. The outcome will be the change in total score from baseline to the post-intervention assessment. | ClinicalTrials.gov |
| Secondary | University of California, Los Angeles, Loneliness Scale | Change from Baseline at 13 weeks | The University of California, Los Angeles Loneliness Scale assesses perceived loneliness and social isolation. The scale contains 20 items rated from 1 to 4. Total scores range from 20 to 80. Higher scores indicate greater loneliness. The outcome will be the change in total score from baseline to the post-intervention assessment. | ClinicalTrials.gov |
| Secondary | Chinese Happiness Inventory | Change from Baseline at 13 weeks | The 10-item Chinese Happiness Inventory assesses subjective happiness and well-being during the previous 3 months. Item scores are added to produce a total score. Higher scores indicate greater subjective happiness and well-being. The outcome will be the change in total score from baseline to the post-intervention assessment. | ClinicalTrials.gov |
| Secondary | Visual Analogue Scale of Subjective Cognitive Function | Change from Baseline at 13 weeks | Participants rate their perceived cognitive function on a 100-millimeter horizontal visual analogue scale. The left endpoint, 0 millimeters, represents the worst perceived cognitive function, and the right endpoint, 100 millimeters, represents the best perceived cognitive function. The score is the distance in millimeters from the left endpoint to the participant's mark and ranges from 0 to 100. Higher scores indicate better perceived cognitive function. The outcome will be the change in score from baseline to the post-intervention assessment. | ClinicalTrials.gov |
| Secondary | System Usability Scale | Within 1 week after completion of the 12-week intervention (Week 13) | The System Usability Scale assesses participants' perceived usability of the digital intervention. It contains 10 items rated on a 5-point scale. Item scores are converted and multiplied by 2.5 to produce a total score ranging from 0 to 100. Higher scores indicate better perceived usability. | ClinicalTrials.gov |
| Secondary | Acceptability of Intervention Measure | Within 1 week after completion of the 12-week intervention (Week 13) | The Acceptability of Intervention Measure assesses participants' perceived acceptability of the assigned intervention. It contains 4 items rated on a 5-point scale. The mean of the 4 item scores ranges from 1 to 5. Higher scores indicate greater intervention acceptability. | ClinicalTrials.gov |
Outcomes 0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
| Type | Outcome | Time frame | Population | Units | Measured as | Source |
|---|
Results by group 0
Each measurement the trial posted, group by group, in the words and numbers it posted.
| Outcome | Group | Category | Value | Spread | Units | Source |
|---|
Participant flow 0
How many started, completed or left each group, period by period.
| Period | Milestone | Group | Participants | Units counted | Source |
|---|
Adverse events 0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
| Type | Event | Organ system | Group | Affected | At risk | Events | Source |
|---|
Adverse event totals 0
The totals the trial posted for each group.
| Total | Group | Affected | At risk | Source |
|---|
Papers 0
The papers the trial lists on ClinicalTrials.gov.
| PMID | Listed as | Source |
|---|
Grants 0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
| Project | Title | Principal investigators | Organization | Funder | Fiscal years | Source |
|---|
Trial comparisons 0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
| Comparison | Source |
|---|
Tests 5
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
| Test | Named as | Source |
|---|---|---|
| Verbal Fluency | Primary outcome | ConductCognition |
| Verbal Learning | Primary outcome | ConductCognition |
| Digit Span Test | Secondary outcome | ConductCognition |
| Stroop Color-Word Test | Secondary outcome | ConductCognition |
| Symbol Coding | Secondary outcome | ConductCognition |
Source 5
| Field | Value | Source |
|---|---|---|
| Release | trials-2026-11-12-0.4.0 | ClinicalTrials.gov |
| Release manifest SHA-256 | 0f4a8d8c48aee2a7573ae0fa94ecbeab70c1adbe449bbc95c424bc7d3e97b9d4 | ClinicalTrials.gov |
| Registry capture | 2026-11-12 | ClinicalTrials.gov |
| Results copy, AACT | 2026-03-23 | ClinicalTrials.gov |
| NIH clinical studies file | 2026-11-13 | ClinicalTrials.gov |
Release trials-2026-11-12-0.4.0
ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
NIH RePORTER's clinical studies and project files: Public domain (NIH RePORTER)