Music-4-MS to Improve Cognition in People Living With Multiple Sclerosis: A Feasibility Study
NCT07759115, Not applicable, Recruiting, University of Texas at Austin
Trial 10
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
| Field | Value | Source |
|---|---|---|
| Title | Music-4-MS to Improve Cognition in People Living With Multiple Sclerosis: A Feasibility Study | ClinicalTrials.gov |
| NCT number | NCT07759115 | ClinicalTrials.gov |
| Status | Recruiting | ClinicalTrials.gov |
| Phases | Not applicable | ClinicalTrials.gov |
| Enrollment | 64 participants, estimated | ClinicalTrials.gov |
| Lead sponsor | University of Texas at Austin | ClinicalTrials.gov |
| Conditions | Multiple Sclerosis, Pathologic Processes, Demyelinating Autoimmune Diseases, CNS, Autoimmune Diseases of the Nervous System, Nervous System Diseases, Demyelinating Diseases, Autoimmune Diseases, Immune System Diseases | ClinicalTrials.gov |
| Interventions | Music Training Intervention, Music Listening | ClinicalTrials.gov |
| First posted | 2026-08-12 | ClinicalTrials.gov |
| Last updated | 2026-08-17 | ClinicalTrials.gov |
Registered outcomes 15
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description | Source |
|---|---|---|---|---|
| Primary | Feasibility: Engagement | Immediately post-intervention | Feasibility will be assessed by quantifying weekly participation in Music-4-MS using the activity metrics from the online platform Teachable. | ClinicalTrials.gov |
| Primary | Feasibility: Retention | Immediately post-intervention | Feasibility will be evaluated by quantifying how many participants drop out throughout the course of the study. | ClinicalTrials.gov |
| Primary | Feasibility: Recruitment | Immediately post-intervention | Feasibility will be assessed by quantifying how many people accept the invitation to participate in the study. | ClinicalTrials.gov |
| Primary | Musical Training Intervention Acceptability | Immediately post-intervention | Acceptability will be evaluated with semi-structured interview questions to understand the participant's perception of MTI delivery and content and the perceived impact. | ClinicalTrials.gov |
| Primary | Music Listening Intervention Acceptability | Immediately post-intervention | Acceptability will be assessed by having participants rate a series of eight statements from 1 (Strongly Disagree) to 7 (Strongly Agree), and answer three open-ended questions based on their experience with the music listening program. | ClinicalTrials.gov |
| Secondary | Mean Change from Baseline in Functional Well-Being Scores at 12 weeks and 16 weeks | Immediately post-intervention and 1-month post-intervention | The Patient-Reported Outcomes Measurement Information System (PROMIS)-29 Profile v2.0 will be used. The survey measures physical function, anxiety, depression, fatigue, sleep disturbance, ability to participate in social roles and activities, and pain interference. Each domain is scored from 4 to 20. | ClinicalTrials.gov |
| Secondary | Mean Change from Baseline in Cognitive Function at 12 weeks and 16 weeks | Immediately post-intervention and 1-month post-intervention | The Patient-Reported Outcomes Measurement Information System (PROMIS) Cognition Function Short-Form will be used. The minimum score is 8, and the maximum score is 40. Higher scores indicate more cognitive impairment. | ClinicalTrials.gov |
| Secondary | Mean Change from Baseline in Upper Extremity Function Scores at 12 weeks and 16 weeks | Immediately post-intervention and 1-month post-intervention | The Patient-Reported Outcomes Measurement Information System (PROMIS) Upper Extremity Function (Fine Motor, ADL) - Short Form will be used. The minimum score is 8, and the maximum score is 40. Higher scores indicate more more upper extremity function. | ClinicalTrials.gov |
| Secondary | Mean Change from Baseline in Objective Hand Dexterity Scores at 12 weeks and 16 weeks | Immediately post-intervention and 1-month post-intervention | The 9-Hole Peg Test (9HPT) will be used. The 9HPT is a timed task completed with both hands independently, with a lower time indicating more hand dexterity. | ClinicalTrials.gov |
| Secondary | Mean Change from Baseline in Subjective Hand Dexterity Scores at 12 weeks and 16 weeks | Immediately post-intervention and 1-month post-intervention | The ABILHAND Questionnaire will be used. There are 26 activities listed and the participants responds with impossible, difficult, or easy to complete. An increased number of impossible and difficult responses indicates lower hand dexterity. | ClinicalTrials.gov |
| Secondary | Mean Change from Baseline in Loneliness Scores at 12 weeks and 16 weeks. | Immediately post-intervention and 1-month post-intervention | The NIH Toolbox - Emotional Battery Loneliness will be used. It is a 5-item survey with responses graded on a 5-point scale from 'never' to 'always' assessing feelings of loneliness and social isolation. | ClinicalTrials.gov |
| Secondary | Mean Change from Baseline in Attention Scores at 12 weeks and 16 weeks | Immediately post-intervention and 1-month post-intervention | The Trail Making A\&B will be used to measure attention. Trails A and B are two separate timed tests. Faster time means greater attention. | ClinicalTrials.gov |
| Secondary | Mean Change from Baseline in Memory Scores at 12 weeks and 16 weeks | Immediately post-intervention and 1-month post-intervention | Immediate and delayed recognition tests will be used. Participant are shown 10 words to memorize. In the immediate recognition test, they are immediately asked to identify the 10 words they memorized out of a list of 20. Later in the testing series, participants will again be asked to recall the 10 words. The number of correct responses will be scored. Higher scores means better memory. | ClinicalTrials.gov |
| Secondary | Mean Change from Baseline in Executive Functioning Scores at 12 weeks and 16 weeks | Immediately post-intervention and 1-month post-intervention | The Digit-Symbol Substitution will be used to measure processing speed and accuracy to evaluate executive functioning. In this test, participants match arbitrary symbols to digits. Scores are calculated by the number of trials correctly completed in 60 seconds. | ClinicalTrials.gov |
| Secondary | Mean Change from Baseline in Executive Functioning Scores at 12 weeks and 16 weeks | Immediately post-intervention and 1-month post-intervention | The Stroop Color and Word Test evaluates impulse control and inhibition to evaluate executive functioning. When the name of a color (e.g., "blue," "green," or "red") is displayed in an incongruent color, name (for example, the word "blue" printed in red), naming the color of the word takes longer and is more prone to errors than when the word and color are congruent or neutral. The scoring uses median duration of incongruent trials. | ClinicalTrials.gov |
Outcomes 0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
| Type | Outcome | Time frame | Population | Units | Measured as | Source |
|---|
Results by group 0
Each measurement the trial posted, group by group, in the words and numbers it posted.
| Outcome | Group | Category | Value | Spread | Units | Source |
|---|
Participant flow 0
How many started, completed or left each group, period by period.
| Period | Milestone | Group | Participants | Units counted | Source |
|---|
Adverse events 0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
| Type | Event | Organ system | Group | Affected | At risk | Events | Source |
|---|
Adverse event totals 0
The totals the trial posted for each group.
| Total | Group | Affected | At risk | Source |
|---|
Papers 0
The papers the trial lists on ClinicalTrials.gov.
| PMID | Listed as | Source |
|---|
Grants 1
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
| Project | Title | Principal investigators | Organization | Funder | Fiscal years | Source |
|---|---|---|---|---|---|---|
| R21NR022143 | Music-4-MS to Improve Cognition in People Living with Multiple Sclerosis: A Feasibility Study | Phillips, Carolyn | UNIVERSITY OF TEXAS AT AUSTIN | NATIONAL INSTITUTE OF NURSING RESEARCH | 2026 | NIH RePORTER |
Trial comparisons 0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
| Comparison | Source |
|---|
Tests 3
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
| Test | Named as | Source |
|---|---|---|
| Stroop Color-Word Test | Secondary outcome | ConductCognition |
| Symbol Coding | Secondary outcome | ConductCognition |
| Trail Making Test A | Secondary outcome | ConductCognition |
Source 5
| Field | Value | Source |
|---|---|---|
| Release | trials-2026-11-12-0.4.0 | ClinicalTrials.gov |
| Release manifest SHA-256 | 0f4a8d8c48aee2a7573ae0fa94ecbeab70c1adbe449bbc95c424bc7d3e97b9d4 | ClinicalTrials.gov |
| Registry capture | 2026-11-12 | ClinicalTrials.gov |
| Results copy, AACT | 2026-03-23 | ClinicalTrials.gov |
| NIH clinical studies file | 2026-11-13 | ClinicalTrials.gov |
Release trials-2026-11-12-0.4.0
ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
NIH RePORTER's clinical studies and project files: Public domain (NIH RePORTER)