Effects of Short-Term Creatine Supplementation on Cognitive Function in Healthy Young Adults
NCT07867041, Not applicable, Completed, University of Northern Iowa
Trial 10
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
| Field | Value | Source |
|---|---|---|
| Title | Effects of Short-Term Creatine Supplementation on Cognitive Function in Healthy Young Adults | ClinicalTrials.gov |
| NCT number | NCT07867041 | ClinicalTrials.gov |
| Status | Completed | ClinicalTrials.gov |
| Phases | Not applicable | ClinicalTrials.gov |
| Enrollment | 24 participants, actual | ClinicalTrials.gov |
| Lead sponsor | University of Northern Iowa | ClinicalTrials.gov |
| Conditions | Cognitive Function Assessment, Mental Fatigue | ClinicalTrials.gov |
| Interventions | Creatine Monohydrate, Maltodextrin Placebo | ClinicalTrials.gov |
| First posted | 2026-10-09 | ClinicalTrials.gov |
| Last updated | 2026-10-21 | ClinicalTrials.gov |
Registered outcomes 6
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description | Source |
|---|---|---|---|---|
| Primary | Cognitive Performance Standard Scores Assessed by Central Nervous System Vital Signs (CNSVS) | Baseline and after 10 days of supplementation | Cognitive performance was assessed using the Central Nervous System Vital Signs (CNSVS) computerized neurocognitive assessment battery. Standardized scores were obtained for cognitive domains including memory, psychomotor speed, reaction time, complex attention, cognitive flexibility, processing speed, executive function, simple attention, and motor speed. Standard scores are age-normalized with a mean of 100 and standard deviation of 15, with higher scores indicating better cognitive performance. | ClinicalTrials.gov |
| Primary | Stroop Task Performance - Reaction Time | Baseline and after 10 days of supplementation | Mean reaction time during the Stroop cognitive task, measured in milliseconds. Reaction times will be averaged across the specified task blocks at each assessment time point. | ClinicalTrials.gov |
| Primary | Stroop Test Performance - Accuracy | Baseline and after 10 days of supplementation. | Accuracy during the Stroop cognitive task, expressed as the percentage of correctly completed trials at each assessment time point. | ClinicalTrials.gov |
| Secondary | Concentration of Prefrontal Cortex Oxygenation Assessed by Functional Near-Infrared Spectroscopy | Baseline and after 10 days of supplementation | Concentration of prefrontal cortex oxygenation was assessed using functional near-infrared spectroscopy (fNIRS; OctaMon+). Cerebral hemodynamic responses during cognitive testing were quantified using changes in oxygenated hemoglobin (O2Hb), deoxygenated hemoglobin (HHb), total hemoglobin (THb), and hemoglobin difference (HbDiff). | ClinicalTrials.gov |
| Secondary | Subjective Mental Fatigue Assessed Using a Visual Analog Scale | During cognitive testing at baseline and after 10 days of supplementation | Subjective mental fatigue was assessed using a visual analog scale (VAS) during each cognitive testing session. Ratings were obtained at five time points: before cognitive testing, midway through the 30-minute Stroop task, immediately following the Stroop task, midway through the CNS Vital Signs assessment, and following completion of the CNS Vital Signs assessment. | ClinicalTrials.gov |
| Secondary | Subjective Energy Assessed Using a Visual Analog Scale | During cognitive testing at baseline and after 10 days of supplementation. | Subjective energy was assessed using a visual analog scale (VAS) during each cognitive testing session. Ratings were obtained at five time points: before cognitive testing, midway through the 30-minute Stroop task, immediately following the Stroop task, midway through the CNS Vital Signs assessment, and following completion of the CNS Vital Signs assessment. | ClinicalTrials.gov |
Outcomes 0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
| Type | Outcome | Time frame | Population | Units | Measured as | Source |
|---|
Results by group 0
Each measurement the trial posted, group by group, in the words and numbers it posted.
| Outcome | Group | Category | Value | Spread | Units | Source |
|---|
Participant flow 0
How many started, completed or left each group, period by period.
| Period | Milestone | Group | Participants | Units counted | Source |
|---|
Adverse events 0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
| Type | Event | Organ system | Group | Affected | At risk | Events | Source |
|---|
Adverse event totals 0
The totals the trial posted for each group.
| Total | Group | Affected | At risk | Source |
|---|
Papers 0
The papers the trial lists on ClinicalTrials.gov.
| PMID | Listed as | Source |
|---|
Grants 0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
| Project | Title | Principal investigators | Organization | Funder | Fiscal years | Source |
|---|
Trial comparisons 0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
| Comparison | Source |
|---|
Tests 1
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
| Test | Named as | Source |
|---|---|---|
| Stroop Color-Word Test | Primary outcome | ConductCognition |
Source 5
| Field | Value | Source |
|---|---|---|
| Release | trials-2026-11-12-0.4.0 | ClinicalTrials.gov |
| Release manifest SHA-256 | 0f4a8d8c48aee2a7573ae0fa94ecbeab70c1adbe449bbc95c424bc7d3e97b9d4 | ClinicalTrials.gov |
| Registry capture | 2026-11-12 | ClinicalTrials.gov |
| Results copy, AACT | 2026-03-23 | ClinicalTrials.gov |
| NIH clinical studies file | 2026-11-13 | ClinicalTrials.gov |
Release trials-2026-11-12-0.4.0
ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
NIH RePORTER's clinical studies and project files: Public domain (NIH RePORTER)