Trial · NCT07877701
Acute Nicotine Gum and Auditory Brain Responses in Adults With Chronic Tinnitus
NCT07877701, Phase 1, Phase 2, Not yet recruiting, San Diego State University
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. Acute Nicotine Gum and Auditory Brain Responses in Adults With Chronic Tinnitus. Trials, record NCT07877701. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT07877701
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- Acute Nicotine Gum and Auditory Brain Responses in Adults With Chronic Tinnitus
- NCT number
- NCT07877701
- Status
- Not yet recruiting
- Phases
- Phase 1, Phase 2
- Enrollment
- 20 participants, estimated
- Lead sponsor
- San Diego State University
- Conditions
- Tinnitus, Chronic Subjective Tinnitus
- Interventions
- Nicotine polacrilex gum 4 mg, Placebo gum
- First posted
- 2026-10-16
- Last updated
- 2026-11-06
Source ClinicalTrials.gov
Registered outcomes10
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Auditory oddball P3 amplitude after administration (nicotine vs placebo) | Up to 2 hours after gum administration | P3 (P300) peak amplitude in microvolts was measured from the event-related potential elicited by target tones during an active auditory oddball task performed after gum administration, at electrodes Fz, Cz, Pz, and Oz. Amplitude was compared between the nicotine and placebo sessions. |
| Primary | Auditory oddball P3 latency after administration (nicotine vs placebo) | Up to 2 hours after gum administration | P3 (P300) peak latency in milliseconds was measured from the event-related potential elicited by target tones during an active auditory oddball task performed after gum administration, at electrodes Fz, Cz, Pz, and Oz. Latency was compared between the nicotine and placebo sessions. |
| Primary | Auditory oddball target-detection accuracy after administration (nicotine vs placebo) | Up to 2 hours after gum administration | Behavioral accuracy (percentage of target tones correctly detected) in the active auditory oddball task performed after gum administration was compared between the nicotine and placebo sessions. |
| Primary | Auditory oddball reaction time after administration (nicotine vs placebo) | Up to 2 hours after gum administration | Mean reaction time in milliseconds to correctly detected target tones in the active auditory oddball task performed after gum administration was compared between the nicotine and placebo sessions. |
| Secondary | Resting-state EEG spectral power and aperiodic (1/f) slope after administration (nicotine vs placebo) | Up to 2 hours after gum administration | Resting-state EEG was recorded after gum administration. Absolute spectral power was computed for the delta, theta, alpha, beta, and gamma frequency bands, and the aperiodic (1/f) slope of the power spectrum was estimated, at electrodes Fz, Cz, Pz, and Oz. Values were compared between the nicotine and placebo sessions. |
| Secondary | Auditory oddball sensitivity (d') after administration (nicotine vs placebo) | Up to 2 hours after gum administration | Signal-detection sensitivity (d') computed from hits and false alarms in the active auditory oddball task performed after gum administration was compared between the nicotine and placebo sessions. |
| Other | Within-session change in psychoacoustic tinnitus loudness match (nicotine vs placebo) | Baseline (pre-administration) and up to 2 hours after gum administration | Tinnitus loudness was matched to the participant's tinnitus pitch by a method-of-adjustment procedure and expressed in dB sensation level. The pre-to-post change was compared between the nicotine and placebo sessions. |
| Other | Tinnitus Handicap Inventory (THI) score | Baseline (pre-administration, first session) | The Tinnitus Handicap Inventory is a 25-item self-report questionnaire of tinnitus-related handicap. Each item is answered yes (4 points), sometimes (2 points), or no (0 points). The total score ranges from 0 to 100; higher scores indicate greater tinnitus handicap (a worse outcome). |
| Other | Tinnitus Functional Index (TFI) score | Baseline (pre-administration, first session) | The Tinnitus Functional Index is a 25-item self-report questionnaire of the functional impact of tinnitus. Each item is rated on a 0-10 scale, and the overall score is the mean of the answered items multiplied by 10. The overall score ranges from 0 to 100; higher scores indicate more severe tinnitus impact (a worse outcome). |
| Other | Pure-tone audiometry (0.25-12 kHz) | Baseline (pre-administration, first session) | Baseline hearing thresholds, collected once at the start of the first session. |
Source ClinicalTrials.gov
Outcomes0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
None in this release.
Results by group0
Each measurement the trial posted, group by group, in the words and numbers it posted.
None in this release.
Participant flow0
How many started, completed or left each group, period by period.
None in this release.
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals0
The totals the trial posted for each group.
None in this release.
Papers0
The papers the trial lists on ClinicalTrials.gov.
None in this release.
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests1
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
| Test | Named as |
|---|---|
| Oddball Target Detection | Primary outcome |
Source ConductCognition
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT07877701
GET https://conductscience.org/api/trials/v1/NCT07877701/registered