Trial · NCT07878130
An Investigation of Mechanisms That Underly Paranoia in Behaviour and Brain That Can Inform Clinical Diagnoses That Include Paranoid Symptoms.
NCT07878130, Phase 2, Not yet recruiting, King's College London
3 sourcestrials-2026-11-12-0.5.0
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ConductScience Library. An Investigation of Mechanisms That Underly Paranoia in Behaviour and Brain That Can Inform Clinical Diagnoses That Include Paranoid Symptoms. Trials, record NCT07878130. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT07878130
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Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- An Investigation of Mechanisms That Underly Paranoia in Behaviour and Brain That Can Inform Clinical Diagnoses That Include Paranoid Symptoms.
- NCT number
- NCT07878130
- Status
- Not yet recruiting
- Phases
- Phase 2
- Enrollment
- 100 participants, estimated
- Lead sponsor
- King's College London
- Conditions
- None Volunteer
- Interventions
- Low-dose THC administration via IV, High-Dose THC administration via IV, Saline administration via IV
- First posted
- 2026-10-16
- Last updated
- 2026-10-16
Source ClinicalTrials.gov
Registered outcomes10
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Harmful intent attribution | Study day 1 to 4, max. within three months, i.e. baseline visit, experimental visit 1 - after intervention and task, experimental visit 2 - after intervention and task, experimental visit 3 - after intervention and task | Participants will play a task (Sharing Game), where they have make intent attributions to an agent they are interacting with. The attribution will be made on a visual analogue scale ranging from 1 to 100 with higher numbers representing more harmful intent attribution. The outcome variable will be estimated using a computational model that takes more aspects of the task into account |
| Secondary | Social behaviours and decision making under uncertainty as measured by the Sharing Game and similar games. | Study day 1 to 4, max. within three months, i.e. baseline visit, experimental visit 1 - after intervention and task, experimental visit 2 - after intervention and task, experimental visit 3 - after intervention and task | participants are engaging in a set of tasks that measure inference and decision making. Outcome measures are estimated using a computational model that takes other aspects of the task and decision making into account as is custom in computational modeling of behaviour in cognitive psychology and computational psychiatry. |
| Secondary | Immediate recall on the HVLT-R | Study day 1 to 4, max. within three months, i.e. baseline visit, experimental visit 1 - before intervention, experimental visit 2 - before intervention and task, experimental visit 3 - before intervention and task | Hopkins verbal learning task - Revised (HVLT-R) is a part of the MATRICS Consensus Cognitive Battery (PAR, Inc FL 33549). The first phase of the test is an immediate recall phase where participants are read a list of 12 words across three trials (nouns from three taxonomic categories) and participants have to recall the words immediately after. There are 5 validated versions of the HVLT-R and the order of test versions will be randomised for each participant to prevent potential order effects. The more words recalled the higher the score. |
| Secondary | Delayed recall on the HVLT-R | Study day 1 to 4, max. within three months, i.e. baseline visit, experimental visit 1 - before intervention, experimental visit 2 - before intervention and task, experimental visit 3 - before intervention and task | Hopkins verbal learning task - Revised (HVLT-R) is a part of the MATRICS Consensus Cognitive Battery (PAR, Inc FL 33549). It consists of an immediate recall phase where participants are read a list of 12 words across three trials (nouns from three taxonomic categories). This is followed by a delayed free recall phase between 20-25 minutes after completion of the immediate recall phase where then participant is asked to recall as many of the words from the list as they can remember. Repetitions and intrusions (words recalled not part of the original list) will also be recorded for each trial. There are 5 validated versions of the HVLT-R and the order of test versions will be randomised for each participant to prevent potential order effects. Delayed recall is measured by how many words are remembered after the delayed free recall phase. More words remembered result in higher scores. |
| Secondary | Working memory performance (Digit Span) | Study day 1, i.e. Baseline visit | Forward and reverse digit span refers to the longest list of numbers the participant can correctly recall, both in forward and backward order. The task starts at the length of four digits (three for backward) and is increased by one digit for each successful trial. The task is ended when the participant fails to give the correct order after two consecutive attempts. The further participants get in the test the better working memory performance. |
| Secondary | Paranoia score (SPSS) | Study day 1 to 4, max. within three months, i.e. Baseline visit, Experimental visit 1 - before intervention, Experimental visit 2 - before intervention, Experimental visit 3 - before intervention | State social paranoia scale (SSPS) is a 10-item instrument which measures persecutory thoughts. The persecutory items (e.g. 'someone had bad intentions towards me') are presented among 10 neutral items and scored on a 5-point scale (do not agree - totally agree). |
| Secondary | Positive psychotic symptoms (PANSS-P) | Study day 1 to 4, max. within three months, i.e. Baseline visit, Experimental visit 1 - before intervention, Experimental visit 2 - before intervention, Experimental visit 3 - before intervention | Positive and negative syndrome scale - positive subscale (PANSS-P) is the most common scale to measure psychotic symptoms and commonly used in schizophrenia research. The PANSS is an investigator rated scale and is scored following a semi-structured interview. In this study only the positive subscale will be used, which include the following symptoms: delusions, conceptual disorganisation, hallucinations, hyperactivity, grandiosity, suspiciousness and hostility. The symptoms are scored on a 7-point scale from absent-severe. |
| Secondary | Mood States | Study day 2 to 4, max. within three months, i.e. Experimental visit 1 - before and after intervention, Experimental visit 2 - before and after intervention, Experimental visit 3 - before and after intervention | Visual analogue scales (VAS) consist of words which describe feeling states and a 100mm horizontal line on which the participant indicates with a vertical line how much of that feeling they have experienced in the moment. The scale ranges from "Not at all" (0mm) to "As much as could possibly be" (100mm). |
| Secondary | Paranoia | Study day 2 to 4, max. within three months, i.e. Experimental visit 1 - before and after intervention, Experimental visit 2 - before and after intervention, Experimental visit 3 - before and after intervention | Visual analogue scales (VAS) consist of words which describe feeling states and a 100mm horizontal line on which the participant indicates with a vertical line how much of that feeling they have experienced in the moment. The scale ranges from "Not at all" (0mm) to "As much as could possibly be" (100mm). Six paranoia VAS from Freeman et al., (2015) will also be included: "Right now I feel suspicious of other people," "Right now I feel that people want to harm me," "Right now I feel like people want to upset me," "Right now I feel like people are against me," "Right now I am thinking that others are trying to persecute me," and "Right now I feel like people are being hostile towards me". |
| Secondary | Heartrate related markers | Study day 1 to 4, max. within three months, i.e. Baseline visit - before and during task, Experimental visit 1 - before and during task, Experimental visit 2 - before and during task, Experimental visit 3 - before and during task | Heart beat will be measured using a standard pulse-oximeter. Systolic blood pressure peaks will be used as a proxy for the R-peak and Inter-beat-intervals will be calculated based on consecutive systolic blood pressure peaks. Heart rate variability will be operationalized as RMSSD based on these inter-beat-intervals. |
Source ClinicalTrials.gov
Outcomes0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
None in this release.
Results by group0
Each measurement the trial posted, group by group, in the words and numbers it posted.
None in this release.
Participant flow0
How many started, completed or left each group, period by period.
None in this release.
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals0
The totals the trial posted for each group.
None in this release.
Papers0
The papers the trial lists on ClinicalTrials.gov.
None in this release.
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests3
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
| Test | Named as | Source |
|---|---|---|
| Delayed Recall Module | Secondary outcome | ConductCognition |
| Digit Span Test | Secondary outcome | ConductCognition |
| Verbal Learning | Secondary outcome | ConductCognition |
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
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