Trial · NCT07879651
SPutum Induction and Nebuliser deviCEs for Patients With CF
NCT07879651, Not applicable, Not yet recruiting, Royal Brompton & Harefield NHS Foundation Trust
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. SPutum Induction and Nebuliser deviCEs for Patients With CF. Trials, record NCT07879651. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT07879651
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- SPutum Induction and Nebuliser deviCEs for Patients With CF
- NCT number
- NCT07879651
- Status
- Not yet recruiting
- Phases
- Not applicable
- Enrollment
- 30 participants, estimated
- Lead sponsor
- Royal Brompton & Harefield NHS Foundation Trust
- Conditions
- Cystic Fibrosis (CF), Cystic Fibrosis Lung Disease
- Interventions
- Sputum induction
- First posted
- 2026-10-19
- Last updated
- 2026-10-19
Source ClinicalTrials.gov
Registered outcomes6
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Feasibility of participant recruitment and retention | From participant enrolment to completion of the second study visit, assessed up to 3 months from first visit | Feasibility will be assessed by the number of eligible participants who consent to participate and the number of enrolled participants who complete both study visits. Recruitment and retention rates will be calculated to determine the feasibility of conducting a future definitive randomised controlled trial comparing nebuliser devices for sputum induction in adults with cystic fibrosis. |
| Secondary | Successful sputum sample collection | During sputum induction at Visits 1 and 2, assessed within 90 minutes per visit, up to 3 months after enrolment | Sputum induction success will be assessed as whether a sputum sample of at least 1 mL is successfully obtained during each sputum induction procedure (yes/no). Success will be recorded separately for sputum induction performed using the jet nebuliser and the E-flow Rapid nebuliser. |
| Secondary | Classification of collected samples as sputum or saliva | Following sample collection at Visits 1 and 2, up to 3 months after enrolment | Collected samples will be assessed using a study-specific standardised visual sputum scoring system. Samples will be characterised using macroscopic features including colour and viscosity to determine the presence of sputum and differentiate sputum from saliva. Assessments will be performed independently by the physiotherapist and laboratory personnel using direct assessment and the corresponding video recording |
| Secondary | Participant-reported acceptability of sputum induction | Immediately following sputum induction at Visits 1 and 2, up to 3 months after enrolment | Participant experience of sputum induction using each nebuliser device will be assessed using a study-specific questionnaire completed after each study visit. The questionnaire assesses participant preference, ease of use, comfort, tolerance, and overall acceptability. Responses will be recorded using a five-point Likert scale ranging from "strongly agree" to "strongly disagree", where appropriate. |
| Secondary | Duration of sputum induction procedure | During sputum induction at Visits 1 and 2, assessed within 90 minutes per visit, up to 3 months after enrolment | The duration of the sputum induction procedure will be recorded for each nebuliser device. Procedure duration will be assessed separately for sputum induction performed using the jet nebuliser and the E-flow Rapid nebuliser. |
| Other | Microbiological yield of induced sputum samples | Samples collected at Visits 1 and 2, up to 3 months after enrolment; results assessed following laboratory processing | Induced sputum samples successfully obtained using each nebuliser device will undergo routine microbiological analysis for cystic fibrosis relevant respiratory pathogens. Analysis will include routine microbiology culture and sensitivity (MC\&S) and non-tuberculous mycobacteria (NTM) testing |
Source ClinicalTrials.gov
Outcomes0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
None in this release.
Results by group0
Each measurement the trial posted, group by group, in the words and numbers it posted.
None in this release.
Participant flow0
How many started, completed or left each group, period by period.
None in this release.
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals0
The totals the trial posted for each group.
None in this release.
Papers16
The papers the trial lists on ClinicalTrials.gov.
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT07879651
GET https://conductscience.org/api/trials/v1/NCT07879651/registered