Trial · NCT07879820
PSMA-Guided Surgery and Tissue-Resident T-Cell Profiling in Node-Positive Prostate Cancer
NCT07879820, Not applicable, Recruiting, Niguarda Hospital
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. PSMA-Guided Surgery and Tissue-Resident T-Cell Profiling in Node-Positive Prostate Cancer. Trials, record NCT07879820. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT07879820
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- PSMA-Guided Surgery and Tissue-Resident T-Cell Profiling in Node-Positive Prostate Cancer
- NCT number
- NCT07879820
- Status
- Recruiting
- Phases
- Not applicable
- Enrollment
- 12 participants, estimated
- Lead sponsor
- Niguarda Hospital
- Conditions
- Prostate Cancer
- Interventions
- PSMA-Radioguided Robot-Assisted Radical Prostatectomy With Extended Pelvic Lymph-Node Dissection
- First posted
- 2026-10-19
- Last updated
- 2026-10-19
Source ClinicalTrials.gov
Registered outcomes2
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Proportion of Evaluable Participants With Successfully Identified and Quantitatively Characterized Functional Pathogen-Specific Bystander Tissue-Resident T Cells | Surgical tissue collected on Day 0; endpoint determined after completion of prespecified molecular and functional analyses during the study period. | Number and percentage of evaluable participants in whom functional pathogen-specific bystander tissue-resident T-cell populations/clonotypes are identified in primary prostate tumor and/or matched metastatic lymph-node tissue. Prespecified criteria include: (1) detection by integrated scRNA-seq, scCITE-seq and scTCR-seq; (2) tissue-resident/non-naive phenotype with predefined residency/activation markers such as CD69, 4-1BB/CD137, CD103 and/or CD49a; (3) ex vivo activation and/or proliferation after stimulation with common viral peptide pools (e.g., CMV, EBV, influenza) versus unstimulated controls; and (4) TCR clonotype identification enabling integration with single-cell/spatial datasets. |
| Secondary | Pathology-Positive Lymph Nodes Detected Only by 68Ga-PSMA Radioguided Surgery | Day 0 surgery; assessed when final pathology is available (recorded by Day 28) | Rate of lymph nodes that are positive at final pathology within the dissection template and were detected only by 68Ga-PSMA-RGS using the drop-in gamma probe. |
Source ClinicalTrials.gov
Outcomes0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
None in this release.
Results by group0
Each measurement the trial posted, group by group, in the words and numbers it posted.
None in this release.
Participant flow0
How many started, completed or left each group, period by period.
None in this release.
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals0
The totals the trial posted for each group.
None in this release.
Papers0
The papers the trial lists on ClinicalTrials.gov.
None in this release.
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT07879820
GET https://conductscience.org/api/trials/v1/NCT07879820/registered