Trial · NCT07880379
MK-0947 PN-002: An Open-label Study to Evaluate Brain α-synuclein Deposition Using Positron Emission Tomography (PET) and [¹⁸F]MK-0947 in Participants With Parkinson's Disease (PD)
NCT07880379, Phase 1, Recruiting, XingImaging, LLC
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. MK-0947 PN-002: An Open-label Study to Evaluate Brain α-synuclein Deposition Using Positron Emission Tomography (PET) and [¹⁸F]MK-0947 in Participants With Parkinson's Disease (PD). Trials, record NCT07880379. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT07880379
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- MK-0947 PN-002: An Open-label Study to Evaluate Brain α-synuclein Deposition Using Positron Emission Tomography (PET) and [¹⁸F]MK-0947 in Participants With Parkinson's Disease (PD)
- NCT number
- NCT07880379
- Status
- Recruiting
- Phases
- Phase 1
- Enrollment
- 18 participants, estimated
- Lead sponsor
- XingImaging, LLC
- Conditions
- Parkinsons Disease (PD), Healthy Elderly Volunteers
- Interventions
- [¹⁸F]MK-0947
- First posted
- 2026-10-19
- Last updated
- 2026-10-19
Source ClinicalTrials.gov
Registered outcomes5
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Brain uptake of [¹⁸F]MK-0947 | From imaging to follow up, an average of 1 year | To visually and quantitatively assess brain uptake of \[¹⁸F\]MK-0947 as a PET radioligand for alpha-synuclein pathology (e.g. Standard Uptake Value Ratios (SUVR)). |
| Primary | Safety of [¹⁸F]MK-0947: Incidence of Adverse Events | From enrollment to follow up, an average of 1 year | Incidence of adverse events (AEs) following administration |
| Primary | Standard Uptake Value Ratios (SUVR) | From imaging to follow up, an average of 1 year | To evaluate Standard Uptake Value Ratios (SUVR) in relevant brain regions from \[18F\]MK-0947 PET in PD and healthy participants. |
| Secondary | Binding Comparison of [¹⁸F]MK-0947 PD and Healthy Elderly | From imaging to follow up, an average of 1 year | To compare the binding of \[¹⁸F\]MK-0947 in the brain of participants with PD with similarly age-matched HE via evaluation of suitable regional quantification parameter (e.g., SUVR) in regions known to be involved in α-synuclein pathology and regions known to not be involved in such pathology. |
| Secondary | Binding Comparison - Camera | From imaging to follow up, an average of 1 year | To compare the binding of \[¹⁸F\]MK-0947 in the brain of participants with PD with that in HE using the standard- and NX- PET |
Source ClinicalTrials.gov
Outcomes0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
None in this release.
Results by group0
Each measurement the trial posted, group by group, in the words and numbers it posted.
None in this release.
Participant flow0
How many started, completed or left each group, period by period.
None in this release.
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals0
The totals the trial posted for each group.
None in this release.
Papers0
The papers the trial lists on ClinicalTrials.gov.
None in this release.
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT07880379
GET https://conductscience.org/api/trials/v1/NCT07880379/registered