Trial · NCT07880730
Right Heart Injury Monitoring on ECMO
NCT07880730, Not yet recruiting, Papworth Hospital NHS Foundation Trust
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. Right Heart Injury Monitoring on ECMO. Trials, record NCT07880730. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT07880730
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- Right Heart Injury Monitoring on ECMO
- NCT number
- NCT07880730
- Status
- Not yet recruiting
- Enrollment
- 30 participants, estimated
- Lead sponsor
- Papworth Hospital NHS Foundation Trust
- Conditions
- Acute Respiratory Distress Syndrome (ARDS), Acute Respiratory Failure (ARF), Right Heart Failure, Unspecified
- Interventions
- Transthoracic echocardiogram, High sensitivity troponin, N-terminal pro-B-type natriuretic peptide
- First posted
- 2026-10-19
- Last updated
- 2026-10-19
Source ClinicalTrials.gov
Registered outcomes8
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Feasibility of RVI monitoring protocol | 2 months | Evaluate the feasibility of implementing a multimodal protocol for monitoring RVI in patients supported with VV-ECMO for severe acute respiratory failure at Royal Papworth Hospital Critical Care Area. |
| Secondary | Echocardiography and biomarkers data | 2 months | Describe how specific RV echocardiographic parameters and biomarkers evolve over the course of VV-ECMO support. |
| Secondary | Description of groups of patients | 12 months | Describe the following groups of patients: 1. With and without RVI 2. With and without early-RVI 3. With and without late-RVI 4. With mild, moderate and severe RVI 5. With RVI that meets and does not meet flow demand |
| Secondary | Changes in patient's management | 2 months | Describe any changes in patient's management that were triggered by the results of the twice-weekly RVI monitoring protocol. |
| Other | Predictors of RVI | 12 months | Can regular monitoring of biomarkers of heart strain (hs-troponin and NT-proBNP) and/or of haemodynamic echocardiographic parameters (pulmonary artery flow acceleration time, RV t-IVT and RV/PA coupling) enable earlier identification of patients who: 1. Will recover from early-RVI when VV-ECMO is started? 2. Will develop RVI whilst on VV-ECMO (late-RVI)? 3. Will develop clinically relevant RVI phenotypes (RV meets or does not meet flow demand)? |
| Other | Markers of heart strain to predict RVI | 12 months | Can hs-troponin and NT-proBNP identify patients that will fulfil echocardiographic criteria of RVI? |
| Other | VV-ECMO outcomes and RVI | 12 months | Are there differences in clinical outcomes (VV-ECMO length, VV-ECMO outcome and CCA length of stay) between patients with: 1. E-RVI and L-RVI? 2. Different RVI phenotypes (mild, moderate and severe)? |
| Other | RVI monitoring protocol and clinical practice | 12 months | Are the clinicians integrating the results of the RVI monitoring protocol into their clinical decision-making process? |
Source ClinicalTrials.gov
Outcomes0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
None in this release.
Results by group0
Each measurement the trial posted, group by group, in the words and numbers it posted.
None in this release.
Participant flow0
How many started, completed or left each group, period by period.
None in this release.
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals0
The totals the trial posted for each group.
None in this release.
Papers4
The papers the trial lists on ClinicalTrials.gov.
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT07880730
GET https://conductscience.org/api/trials/v1/NCT07880730/registered