Trial · NCT07881445
Subchondral Drilling Diameter During CARTISTEM Implantation for Knee Cartilage Defects
NCT07881445, Not applicable, Recruiting, Yonsei University
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. Subchondral Drilling Diameter During CARTISTEM Implantation for Knee Cartilage Defects. Trials, record NCT07881445. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT07881445
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- Subchondral Drilling Diameter During CARTISTEM Implantation for Knee Cartilage Defects
- NCT number
- NCT07881445
- Status
- Recruiting
- Phases
- Not applicable
- Enrollment
- 60 participants, estimated
- Lead sponsor
- Yonsei University
- Conditions
- Osteoarthritis, Knee, Articular Cartilage Defects of the Knee
- Interventions
- 2-mm subchondral drilling, Sequential 4-mm and 2-mm subchondral drilling
- First posted
- 2026-10-19
- Last updated
- 2026-10-19
Source ClinicalTrials.gov
Registered outcomes11
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | IKDC Subjective Knee Evaluation score at 12 months after surgery | 12 months after surgery. Additional protocol measurements occur at 3 and 6 months. | The IKDC Subjective Knee Evaluation score assesses participant-reported knee symptoms and function on a 0-100 scale. Higher scores indicate better function and fewer symptoms. The primary non-inferiority comparison uses the 12-month between-group difference and its 95% confidence interval, with a prespecified margin of 10.3 points. |
| Secondary | Pain visual analog scale | Baseline and 3, 6, and 12 months after surgery | Knee pain assessed using a 10-cm visual analog scale (VAS), recorded from 0 to 10: 0 = no pain; 10 = worst imaginable pain. Higher scores indicate greater pain. Scores and changes from baseline are assessed. |
| Secondary | Lysholm knee score | Baseline and 3, 6, and 12 months after surgery | Patient-reported knee symptoms and function measured using the Lysholm knee score, ranging from 0 to 100; higher scores indicate better knee function. |
| Secondary | Knee injury and Osteoarthritis Outcome Score (KOOS) | Baseline and 3, 6, and 12 months after surgery | The original 42-item Knee injury and Osteoarthritis Outcome Score (KOOS) assesses pain, symptoms, activities of daily living, sport/recreation, and knee-related quality of life. Each of the five subscales is scored separately from 0 to 100; higher scores indicate fewer symptoms and better function. |
| Secondary | MOCART 2.0 knee score | 12 months after surgery | MRI assessment of cartilage repair using the MOCART 2.0 knee score, ranging from 0 to 100; higher scores indicate more favorable repair tissue morphology. |
| Secondary | Subchondral edema assessment | 12 months after surgery | Subchondral edema assessed on MRI using the relevant MOCART 2.0 subscale. |
| Secondary | Presence of subchondral cysts | 12 months after surgery | Presence or absence of subchondral cysts on MRI. |
| Secondary | Presence of subchondral insufficiency fracture | 12 months after surgery | Presence or absence of subchondral insufficiency fracture on MRI. |
| Secondary | ICRS Cartilage Repair Assessment | At second-look arthroscopy during plate removal, planned at 12 months | ICRS Cartilage Repair Assessment at second-look arthroscopy during plate removal in participants with concomitant high tibial osteotomy. Defect filling, integration with adjacent cartilage, and macroscopic appearance are each scored from 0 to 4 and summed to a total of 0 to 12; higher scores indicate better cartilage repair. Overall repair is classified from Grade I (normal) to Grade IV (severely abnormal). |
| Secondary | Kellgren-Lawrence grade | Baseline and 6 and 12 months after surgery | Radiographic osteoarthritis assessed using the Kellgren-Lawrence grade, ranging from 0 to 4; higher grades indicate more severe osteoarthritis. |
1 to 10 of 11Source ClinicalTrials.gov
See all 11 registered outcomesOutcomes0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
None in this release.
Results by group0
Each measurement the trial posted, group by group, in the words and numbers it posted.
None in this release.
Participant flow0
How many started, completed or left each group, period by period.
None in this release.
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals0
The totals the trial posted for each group.
None in this release.
Papers0
The papers the trial lists on ClinicalTrials.gov.
None in this release.
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT07881445
GET https://conductscience.org/api/trials/v1/NCT07881445/registered