Trial · NCT07881757
A Study to Learn About the Monthly Dosing Study Medicine Called Berobenatide in Adults With Breathing Problems During Sleep and Overweight or Obesity Who Do Not Use a Breathing Machine (PAP) (VESPER-OSA 2)
NCT07881757, Phase 3, Recruiting, Pfizer
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. A Study to Learn About the Monthly Dosing Study Medicine Called Berobenatide in Adults With Breathing Problems During Sleep and Overweight or Obesity Who Do Not Use a Breathing Machine (PAP) (VESPER-OSA 2). Trials, record NCT07881757. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT07881757
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
A Study to Learn About the Monthly Dosing Study Medicine Called Berobenatide in Adults With Breathing Problems During Sleep and Overweight or Obesity Who Do Not Use a Breathing Machine (PAP) (VESPER-OSA 2)
- NCT number
- NCT07881757
- Status
- Recruiting
- Phases
- Phase 3
- Enrollment
- 258 participants, estimated
- Lead sponsor
- Pfizer
- Conditions
- Apnea, Sleep Disorders, Overweight and/or Obesity
- Interventions
- Berobenatide, Placebo
- First posted
- 2026-10-19
- Last updated
- 2026-11-06
Source ClinicalTrials.gov
Registered outcomes47
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Change From Baseline in Apnea-Hypopnea Index | Baseline, Week 52 | Apnea-Hypopnea Index is the number of apnea and hypopnea events per hour of sleep, assessed by polysomnography. |
| Secondary | Percent Change From Baseline in Body Weight | Baseline, Week 52 | |
| Secondary | Change From Baseline in High-Sensitivity C-Reactive Protein | Baseline, Week 52 | |
| Secondary | Percent Change From Baseline in Apnea-Hypopnea Index | Baseline, Week 52 | |
| Secondary | Percentage of Participants With at Least 50% Reduction in Apnea-Hypopnea Index | Week 52 | |
| Secondary | Change From Baseline in Sleep-Apnea-Specific Hypoxic Burden (SASHB) | Baseline, Week 52 | |
| Secondary | Percentage of Participants With Obstructive Sleep Apnea Remission or Mild Non-Symptomatic Obstructive Sleep Apnea | Week 52 | |
| Secondary | Change From Baseline in Systolic Blood Pressure | Baseline, Week 52 | |
| Secondary | Change From Baseline in Patient-Reported Outcomes Measurement Information System (PROMIS) Sleep-Related Impairment 8a T-Score | Baseline, Week 52 | |
| Secondary | Change From Baseline in PROMIS Sleep Disturbance 8b T-Score | Baseline, Week 52 |
1 to 10 of 47Source ClinicalTrials.gov
See all 47 registered outcomesOutcomes0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
None in this release.
Results by group0
Each measurement the trial posted, group by group, in the words and numbers it posted.
None in this release.
Participant flow0
How many started, completed or left each group, period by period.
None in this release.
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals0
The totals the trial posted for each group.
None in this release.
Papers0
The papers the trial lists on ClinicalTrials.gov.
None in this release.
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT07881757
GET https://conductscience.org/api/trials/v1/NCT07881757/registered?page=2