Trial · NCT07881861
Cartilage Biomarker Response to Acute Mechanical Loading in Women With Knee Osteoarthritis: Comparison by Antiresorptive Treatment Status
NCT07881861, Recruiting, Sisli Hamidiye Etfal Training and Research Hospital
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. Cartilage Biomarker Response to Acute Mechanical Loading in Women With Knee Osteoarthritis: Comparison by Antiresorptive Treatment Status. Trials, record NCT07881861. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT07881861
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- Cartilage Biomarker Response to Acute Mechanical Loading in Women With Knee Osteoarthritis: Comparison by Antiresorptive Treatment Status
- NCT number
- NCT07881861
- Status
- Recruiting
- Enrollment
- 105 participants, estimated
- Lead sponsor
- Sisli Hamidiye Etfal Training and Research Hospital
- Conditions
- Knee Osteoarthritis
- First posted
- 2026-10-20
- Last updated
- 2026-10-20
Source ClinicalTrials.gov
Registered outcomes6
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Change in serum COMP levels from T0 to T1 comparing denosumab and bisphosphonate groups | Immediately before and within 0-2 minutes after the 30-minute treadmill walking session | Change in serum cartilage oligomeric matrix protein (COMP) levels from immediately before acute mechanical loading (T0) to immediately after the loading protocol (T1), comparing participants receiving denosumab with those receiving bisphosphonate treatment. |
| Primary | Change in serum MMP-3 levels from T0 to T1 comparing denosumab and bisphosphonate groups | Immediately before and within 0-2 minutes after the 30-minute treadmill walking session | Change in serum matrix metalloproteinase-3 (MMP-3) levels from immediately before acute mechanical loading (T0) to immediately after the loading protocol (T1), comparing participants receiving denosumab with those receiving bisphosphonate treatment. |
| Secondary | Change in serum COMP levels from T0 to T1 comparing denosumab and control groups | Immediately before and within 0-2 minutes after the 30-minute treadmill walking session | Change in serum cartilage oligomeric matrix protein (COMP) levels from immediately before acute mechanical loading (T0) to immediately after the loading protocol (T1), comparing participants receiving denosumab with the control group not receiving current antiresorptive treatment. |
| Secondary | Change in serum MMP-3 levels from T0 to T1 comparing denosumab and control groups | Immediately before and within 0-2 minutes after the 30-minute treadmill walking session | Change in serum matrix metalloproteinase-3 (MMP-3) levels from immediately before acute mechanical loading (T0) to immediately after the loading protocol (T1), comparing participants receiving denosumab with the control group not receiving current antiresorptive treatment. |
| Secondary | Change in serum COMP levels from T0 to T1 comparing bisphosphonate and control groups | Immediately before and within 0-2 minutes after the 30-minute treadmill walking session | Change in serum cartilage oligomeric matrix protein (COMP) levels from immediately before acute mechanical loading (T0) to immediately after the loading protocol (T1), comparing participants receiving bisphosphonate treatment with the control group not receiving current antiresorptive treatment. |
| Secondary | Change in serum MMP-3 levels from T0 to T1 comparing bisphosphonate and control groups | Immediately before and within 0-2 minutes after the 30-minute treadmill walking session | Change in serum matrix metalloproteinase-3 (MMP-3) levels from immediately before acute mechanical loading (T0) to immediately after the loading protocol (T1), comparing participants receiving bisphosphonate treatment with the control group not receiving current antiresorptive treatment. |
Source ClinicalTrials.gov
Outcomes0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
None in this release.
Results by group0
Each measurement the trial posted, group by group, in the words and numbers it posted.
None in this release.
Participant flow0
How many started, completed or left each group, period by period.
None in this release.
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals0
The totals the trial posted for each group.
None in this release.
Papers0
The papers the trial lists on ClinicalTrials.gov.
None in this release.
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT07881861
GET https://conductscience.org/api/trials/v1/NCT07881861/registered