Trial · NCT07882394
Alpha-Lipoic Acid as an Adjunct to Non-Surgical Periodontal Treatment in Gingivitis
NCT07882394, Not applicable, Recruiting, Biruni University
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. Alpha-Lipoic Acid as an Adjunct to Non-Surgical Periodontal Treatment in Gingivitis. Trials, record NCT07882394. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT07882394
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- Alpha-Lipoic Acid as an Adjunct to Non-Surgical Periodontal Treatment in Gingivitis
- NCT number
- NCT07882394
- Status
- Recruiting
- Phases
- Not applicable
- Enrollment
- 80 participants, estimated
- Lead sponsor
- Biruni University
- Conditions
- Gingivitis and Periodontal Diseases
- Interventions
- Placebo Administration, Alpha-Lipoic Acid 200 mg, Alpha-Lipoic Acid 600 mg
- First posted
- 2026-10-20
- Last updated
- 2026-10-20
Source ClinicalTrials.gov
Registered outcomes6
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Salivary 8-OHdG | Baseline, 6 weeks, and 12 weeks after non-surgical periodontal treatment | Evaluation of changes in salivary 8-OHdG levels following non-surgical periodontal treatment combined with alpha-lipoic acid (ALA) or placebo supplementation in individuals with gingivitis. Salivary 8-OHdG levels will be measured using an enzyme-linked immunosorbent assay (ELISA). |
| Secondary | Changes in Probing Pocket Depth (PPD) | Baseline, Week 6, and Week 12 | Evaluation of changes in probing pocket depth following non-surgical periodontal therapy combined with ALA or placebo supplementation in individuals with gingivitis. |
| Secondary | Changes in Bleeding on Probing | Baseline, Week 6, and Week 12 | Assessment of changes in bleeding on probing values following non-surgical periodontal therapy combined with ALA or placebo supplementation in individuals with gingivitis. |
| Secondary | Changes in Plaque Score (PS) | Baseline, Week 6, and Week 12 | Assessment of changes in plaque score following non-surgical periodontal therapy combined with ALA or placebo supplementation in individuals with gingivitis. Plaque score will be calculated as the percentage of tooth surfaces with detectable plaque. |
| Secondary | Changes in Salivary MDA, TAC, and CRP Levels | Baseline, Week 6, and Week 12 | Evaluation of changes in salivary oxidative stress and inflammatory biomarkers, including MDA, TAC, and CRP levels, following non-surgical periodontal therapy combined with ALA or placebo supplementation in individuals with gingivitis. |
| Secondary | Changes in Serum 8-OHdG, MDA, TAC, and CRP Levels | Baseline, Week 6, and Week 12 | Evaluation of changes in serum oxidative stress and inflammatory biomarkers, including 8-OHdG, MDA, TAC, and CRP levels, following non-surgical periodontal therapy combined with ALA or placebo supplementation in individuals with gingivitis. |
Source ClinicalTrials.gov
Outcomes0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
None in this release.
Results by group0
Each measurement the trial posted, group by group, in the words and numbers it posted.
None in this release.
Participant flow0
How many started, completed or left each group, period by period.
None in this release.
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals0
The totals the trial posted for each group.
None in this release.
Papers1
The papers the trial lists on ClinicalTrials.gov.
| PMID | Listed as |
|---|---|
| 22702517 | BACKGROUND |
Source PubMed
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT07882394
GET https://conductscience.org/api/trials/v1/NCT07882394/registered