Impact of Continuous Positive Airway Pressure Therapy on Bilateral Local Hippocampal Gray Matter Volume in Elderly Patients With Obstructive Sleep Apnea - Study BBBSAS
NCT07882433, Not applicable, Not yet recruiting, Centre Hospitalier Universitaire de Saint Etienne
Trial 10
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
| Field | Value | Source |
|---|---|---|
| Title | Impact of Continuous Positive Airway Pressure Therapy on Bilateral Local Hippocampal Gray Matter Volume in Elderly Patients With Obstructive Sleep Apnea - Study BBBSAS | ClinicalTrials.gov |
| NCT number | NCT07882433 | ClinicalTrials.gov |
| Status | Not yet recruiting | ClinicalTrials.gov |
| Phases | Not applicable | ClinicalTrials.gov |
| Enrollment | 50 participants, estimated | ClinicalTrials.gov |
| Lead sponsor | Centre Hospitalier Universitaire de Saint Etienne | ClinicalTrials.gov |
| Conditions | Hypopnea Syndrome, Apnea, Obstructive Sleep | ClinicalTrials.gov |
| Interventions | Continuous Positive Airway Pressure (CPAP) therapy, Multimodal brain MRI with Gadolinium injection | ClinicalTrials.gov |
| First posted | 2026-10-20 | ClinicalTrials.gov |
| Last updated | 2026-10-20 | ClinicalTrials.gov |
Registered outcomes 6
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description | Source |
|---|---|---|---|---|
| Primary | Blood-brain barrier (BBB) permeability abnormality in the hippocampus and frontal cortex | months 6 | Assessed using a multimodal MRI protocol (3D T1 MP2RAGE, T2 relaxometry, diffusion tensor imaging, T2\* susceptibility-weighted imaging, dynamic contrast-enhanced perfusion imaging providing the permeability-surface area product \[PS\], and post-Gadolinium 3D T1 MPRAGE), analyzed by voxel-based morphometry and automated hippocampal segmentation. | ClinicalTrials.gov |
| Secondary | Blood-brain barrier (BBB) permeability abnormality in the hippocampus and frontal cortex | months : 6 | Assessed using a multimodal MRI protocol (3D T1 MP2RAGE, T2 relaxometry, diffusion tensor imaging, T2\* susceptibility-weighted imaging, dynamic contrast-enhanced perfusion imaging providing the permeability-surface area product \[PS\], and post-Gadolinium 3D T1 MPRAGE), analyzed by voxel-based morphometry and automated hippocampal segmentation. | ClinicalTrials.gov |
| Secondary | Local white matter volume | 6 months | Voxel-level gray-scale analysis of white matter, using the same MRI acquisitions and analysis pipeline as the primary outcome. | ClinicalTrials.gov |
| Secondary | Dysexecutive / memory cognitive score | 6 months | Composite score derived from a neuropsychological battery (Stroop test, Trail Making Test A/B, verbal fluency, digit span, WAIS-III subtests, free/cued recall, PASAT). | ClinicalTrials.gov |
| Secondary | Dual-task gait and balance performance | 6 months | Step variability and balance time under single- and dual-task walking conditions, measured with pressure-sensor insoles and a force platform. | ClinicalTrials.gov |
| Secondary | Systemic inflammatory and aquaporin biomarkers | 6 months | Serum hs-CRP, IL-1β, IL-6, IL-10, TNF-α and MCP-1 (Luminex®); serum and urinary aquaporin 1 and 3 (ELISA). | ClinicalTrials.gov |
Outcomes 0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
| Type | Outcome | Time frame | Population | Units | Measured as | Source |
|---|
Results by group 0
Each measurement the trial posted, group by group, in the words and numbers it posted.
| Outcome | Group | Category | Value | Spread | Units | Source |
|---|
Participant flow 0
How many started, completed or left each group, period by period.
| Period | Milestone | Group | Participants | Units counted | Source |
|---|
Adverse events 0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
| Type | Event | Organ system | Group | Affected | At risk | Events | Source |
|---|
Adverse event totals 0
The totals the trial posted for each group.
| Total | Group | Affected | At risk | Source |
|---|
Papers 0
The papers the trial lists on ClinicalTrials.gov.
| PMID | Listed as | Source |
|---|
Grants 0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
| Project | Title | Principal investigators | Organization | Funder | Fiscal years | Source |
|---|
Trial comparisons 0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
| Comparison | Source |
|---|
Tests 6
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
| Test | Named as | Source |
|---|---|---|
| Digit Span Test | Secondary outcome | ConductCognition |
| Paced Visual Serial Addition Test | Secondary outcome | ConductCognition |
| Stroop Color-Word Test | Secondary outcome | ConductCognition |
| Trail Making Test A | Secondary outcome | ConductCognition |
| Trail Making Test B | Secondary outcome | ConductCognition |
| Verbal Fluency | Secondary outcome | ConductCognition |
Source 5
| Field | Value | Source |
|---|---|---|
| Release | trials-2026-11-12-0.4.0 | ClinicalTrials.gov |
| Release manifest SHA-256 | 0f4a8d8c48aee2a7573ae0fa94ecbeab70c1adbe449bbc95c424bc7d3e97b9d4 | ClinicalTrials.gov |
| Registry capture | 2026-11-12 | ClinicalTrials.gov |
| Results copy, AACT | 2026-03-23 | ClinicalTrials.gov |
| NIH clinical studies file | 2026-11-13 | ClinicalTrials.gov |
Release trials-2026-11-12-0.4.0
ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
NIH RePORTER's clinical studies and project files: Public domain (NIH RePORTER)