Trial · NCT07882524
Effects of Sedation Agents on Optic Nerve Sheath Diameter
NCT07882524, Completed, Alanya Alaaddin Keykubat University
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. Effects of Sedation Agents on Optic Nerve Sheath Diameter. Trials, record NCT07882524. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT07882524
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- Effects of Sedation Agents on Optic Nerve Sheath Diameter
- NCT number
- NCT07882524
- Status
- Completed
- Enrollment
- 73 participants, actual
- Lead sponsor
- Alanya Alaaddin Keykubat University
- Conditions
- Procedural Sedation
- First posted
- 2026-10-20
- Last updated
- 2026-10-20
Source ClinicalTrials.gov
Registered outcomes8
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Change in Optic Nerve Sheath Diameter (ONSD) From Baseline to 5 Minutes After Sedation | Baseline (before sedation) and 5 minutes after sedation | The primary outcome is the change in optic nerve sheath diameter (ONSD) from baseline to 5 minutes after intravenous sedation with ketamine or propofol. ONSD is measured using ocular ultrasonography in both eyes with the patient in the supine position. Measurements are obtained 3 mm posterior to the globe using a 7.5-MHz linear probe, with minimal pressure applied to the closed eyelid. Changes in ONSD are evaluated within each group and compared between the ketamine and propofol groups. |
| Secondary | Change in Blood Pressure Before and After Sedation | Baseline (before sedation) and 5 minutes after sedation | Changes in systolic and diastolic blood pressure (mmHg) from baseline to 5 minutes after intravenous ketamine or propofol administration are assessed and compared between the two groups. |
| Secondary | Change in Heart Rate Before and After Sedation | Baseline (before sedation) and 5 minutes after sedation | Changes in heart rate (beats/min) from baseline to 5 minutes after intravenous ketamine or propofol administration are assessed and compared between the two groups. |
| Secondary | Change in Peripheral Oxygen Saturation Before and After Sedation | Baseline (before sedation) and 5 minutes after sedation | Changes in peripheral oxygen saturation (SpO₂, %) from baseline to 5 minutes after intravenous ketamine or propofol administration are assessed and compared between the two groups. |
| Secondary | Change in Body Temperature Before and After Sedation | Baseline (before sedation) and 5 minutes after sedation | Changes in body temperature (°C) from baseline to 5 minutes after intravenous ketamine or propofol administration are assessed and compared between the two groups. |
| Secondary | Change in Glasgow Coma Scale (GCS) Score From Pre-Sedation to Post-Sedation | Before sedation and 5 minutes after sedative agent administration | Glasgow Coma Scale (GCS) scores recorded before and 5 minutes after intravenous sedation with ketamine or propofol are assessed and compared within each group and between the two groups. The Glasgow Coma Scale ranges from 3 to 15, with higher scores indicating a better level of consciousness and lower scores indicating greater impairment of consciousness.. |
| Secondary | Number of Participants Requiring an Additional Dose or an Alternative Sedative Agent | From initial sedative administration through the 5-minute post-sedation assessment | The number of participants requiring an additional dose of the initially administered sedative agent or the use of an alternative sedative agent during the sedation procedure are assessed and compared between the ketamine and propofol groups. |
| Secondary | Number of Participants with Clinically Significant Hemodynamic Deterioration Requiring Intervention | From sedative administration through the 5-minute post-sedation assessment | The occurrence of clinically significant hemodynamic deterioration requiring clinical intervention are assessed. Interventions of interest included intravenous fluid administration, vasopressor use, airway manoeuvres, and escalation of oxygen therapy. |
Source ClinicalTrials.gov
Outcomes0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
None in this release.
Results by group0
Each measurement the trial posted, group by group, in the words and numbers it posted.
None in this release.
Participant flow0
How many started, completed or left each group, period by period.
None in this release.
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals0
The totals the trial posted for each group.
None in this release.
Papers0
The papers the trial lists on ClinicalTrials.gov.
None in this release.
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT07882524
GET https://conductscience.org/api/trials/v1/NCT07882524/registered