Trial · NCT07882719
Registered outcomes32
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
1 to 20 of 32
Download this page as JSON| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Average Quadriceps Muscle Activation During Bed-Cycling | During each bed-cycling session (Days 1-3; within a maximum of 5 days). | Average quadriceps muscle activation will be assessed using surface electromyography (sEMG) during the cycling protocols (u-CWR, i-CWR and i-IT). Activation will be expressed as normalized root mean square (RMS) amplitude relative to maximal voluntary contraction (%max), averaged across four quadriceps regions: vastus lateralis, vastus medialis, upper rectus femoris, and lower rectus femoris. |
| Secondary | Quadriceps muscle fatigue (Median Frequency) | During the incremental loading test and each cycling session (Days 0-3; within 5 days). | Muscle fatigue will be assessed by changes in the median frequency (Hz) of the surface electromyography signal over the four quadriceps regions during the incremental loading test and the three cycling protocols. A reduction in median frequency is considered indicative of muscle fatigue. |
| Secondary | Quadriceps muscle fatigue (Frequency ratio) | During the incremental loading test and each cycling session (Days 0-3; within 5 days). | Muscle fatigue will be assessed using changes in the high-frequency to low-frequency ratio of the sEMG signal across the four quadriceps regions during exercise. |
| Secondary | Spatial heterogeneity of quadriceps muscle activation | During the incremental loading test and each cycling session (Days 0-3; within 5 days). | Spatial heterogeneity of quadriceps muscle activation will be quantified as the relative dispersion of normalized sEMG amplitude across four quadriceps regions. Relative dispersion will be calculated as the standard deviation divided by the mean activation across the four regions. |
| Secondary | Quadriceps muscle oxygenation | At rest, during and immediately after the incremental loading test and each cycling session (Days 0-3; within 5 days). | Local quadriceps muscle tissue oxygen saturation (StiO2, %) will be continuously assessed using near-infrared spectroscopy (NIRS) at four muscle regions: vastus lateralis, vastus medialis, upper rectus femoris, and lower rectus femoris. Resting values and oxygenation responses during exercise will be assessed across the cycling protocols. |
| Secondary | Quadriceps muscle hemoglobine and Myoglobine Responses (oxygenated) | At rest, during and immediately after the incremental loading test and each cycling session (Days 0-3; within 5 days). | Near-infrared spectroscopy (NIRS) will be used to assess oxygenated hemoglobin/myoglobin signals in four quadriceps regions during exercise. |
| Secondary | Quadriceps muscle hemoglobine and Myoglobine Responses (deoxygenated) | At rest, during and immediately after the incremental loading test and each cycling session (Days 0-3; within 5 days) | Near-infrared spectroscopy (NIRS) will be used to assess deoxygenated hemoglobin/myoglobin signals in four quadriceps regions during exercise. |
| Secondary | Quadriceps muscle hemoglobine and Myoglobine Responses (total) | At rest, during and immediately after the incremental loading test and each cycling session (Days 0-3; within 5 days). | Near-infrared spectroscopy (NIRS) will be used to assess total hemoglobin/myoglobin signals in four quadriceps regions during exercise. |
| Secondary | Spatial Heterogeneity of Quadriceps Muscle Oxygenation | At rest and during the incremental loading test and each cycling session (Days 0-3; within 5 days). | Spatial heterogeneity of muscle oxygenation will be quantified using the relative dispersion of NIRS-derived muscle tissue oxygen saturation (StiO2) across four quadriceps regions. |
| Secondary | Changes in haert rate during Bed-Cycling | Before, during and immediately after the incremental loading test and each cycling session (Days 0-3; within 5 days). | Hemodynamic responses will be assessed using changes in heart rate (beats/min), measured before, during and after exercise. |
| Secondary | Changes in mean arterial blood pressure during Bed-Cycling | Before, during and immediately after the incremental loading test and each cycling session (Days 0-3; within 5 days). | Hemodynamic responses will be assessed using changes in mean arterial blood pressure (mmHg), measured before, during and after exercise. |
| Secondary | Changes in respiratory rate During Bed-Cycling | Before, during and immediately after the incremental loading test and each cycling session (Days 0-3; within 5 days). | Respiratory responses will be assessed using changes in respiratory rate (breaths/min) before, during and after exercise. |
| Secondary | Changes in peripheral oxygen saturation During Bed-Cycling | Before, during and immediately after the incremental loading test and each cycling session (Days 0-3; within 5 days). | Respiratory responses will be assessed using changes in peripheral oxygen saturation (SpO2, %) before, during and after exercise. |
| Secondary | Changes in fraction of inspired oxygen During Bed-Cycling | Before, during and immediately after the incremental loading test and each cycling session (Days 0-3; within 5 days). | Respiratory responses will be assessed using changes in fraction of inspired oxygen (FiO2, %) before, during and after exercise. |
| Secondary | Changes in Arterial Blood Gas (arterial oxygen partial pressure) During Bed-Cycling | Before and after the incremental loading test and each cycling session (Days 0-3; within 5 days). | arterial oxygen partial pressure (PaO2) obtained as part of routine clinical care will be assessed before and after exercise. |
| Secondary | Changes in Arterial Blood Gas (arterial carbon dioxide partial pressure) During Bed-Cycling | Before and after the incremental loading test and each cycling session (Days 0-3; within 5 days). | Arterial carbon dioxide partial pressure (PaCO2) obtained as part of routine clinical care will be assessed before and after exercise. |
| Secondary | Changes in Arterial Blood Gas (arterial oxygen saturation) During Bed-Cycling | Before and after the incremental loading test and each cycling session (Days 0-3; within 5 days). | arterial oxygen saturation (SaO2) obtained as part of routine clinical care will be assessed before and after exercise. |
| Secondary | Changes in Arterial Blood Gas (pH) During Bed-Cycling | Before and after the incremental loading test and each cycling session (Days 0-3; within 5 days). | pH obtained as part of routine clinical care will be assessed before and after exercise. |
| Secondary | Changes in Arterial Blood Gas (hemoglobin concentration) During Bed-Cycling | Before and after the incremental loading test and each cycling session (Days 0-3; within 5 days). | hemoglobin concentration obtained as part of routine clinical care will be assessed before and after exercise. |
| Secondary | Changes in Arterial Blood Gas (blood lactate concentration) During Bed-Cycling | Before and after the incremental loading test and each cycling session (Days 0-3; within 5 days). | blood lactate concentration obtained as part of routine clinical care will be assessed before and after exercise. |
Source ClinicalTrials.govtrials-2026-11-12-0.5.0
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
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