Trial · NCT07883148
TPSAlz - Transcranial Pulse Stimulation in Alzheimer's Disease
NCT07883148, Not applicable, Completed, IRCCS San Raffaele Roma
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. TPSAlz - Transcranial Pulse Stimulation in Alzheimer's Disease. Trials, record NCT07883148. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT07883148
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- TPSAlz - Transcranial Pulse Stimulation in Alzheimer's Disease
- NCT number
- NCT07883148
- Status
- Completed
- Phases
- Not applicable
- Enrollment
- 52 participants, actual
- Lead sponsor
- IRCCS San Raffaele Roma
- Conditions
- Alzheimer Disease, Mild Cognitive Impairment
- Interventions
- Transcranial pulse stimulation (TPS)
- First posted
- 2026-10-20
- Last updated
- 2026-10-20
Source ClinicalTrials.gov
Registered outcomes12
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Episodic Memory Score (EMS) | Before TPS sessions, at 1-month follow-up and at 8-months follow-up | The stability/improvement of the memory profile in MCI and mild AD patients subjected to TPS treatment, in the short and long term, will be evaluated using Episodic Memory Score (EMS). (integrated neuropsychological assessment tool designed to evaluate verbal and visual episodic memory and predict the progression from amnestic Mild Cognitive Impairment (aMCI) to Alzheimer's disease) Range: from 4 (worst performance) to 12 (best performance). |
| Secondary | EEG functional connectivity | Before TPS sessions, at 1-month follow-up and at 8-months follow-up | To evaluate the changes in electrophysiological indices of functional connectivity, applying graph theory, in MCI and mild AD patients treated with real TPS compared to those treated with placebo TPS, both in the short and long term; Furthermore, identify neurophysiological measurements capable of predicting a positive response to treatment. |
| Secondary | Cortical thickness | Before TPS sessions, at 1-month follow-up and at 8-months follow-up | To evaluate the changes in cortical thickness using radiological data, in the MCI and mild AD groups treated with real TPS compared to the MCI and mild AD groups treated with placebo, both in the short and long term. |
| Secondary | Structural connectivity | Before TPS sessions, at 1-month follow-up and at 8-months follow-up | To evaluate the changes structural connectivity, using radiological data, in the MCI and mild AD groups treated with real TPS compared to the MCI and mild AD groups treated with placebo, both in the short and long term. |
| Secondary | Rey Auditory Verbal Learning Test (RAVLT) | Before TPS sessions, at 1-month follow-up and at 8-months follow-up | neuropsychological tests |
| Secondary | Rey Osterrieth Complex Figure (ROCF) - copy and recall tasks | Before TPS sessions, at 1-month follow-up and at 8-months follow-up | neuropsychological tests |
| Secondary | Episodic Memory Score (EMS) | Before TPS sessions, at 1-month follow-up and at 8-months follow-up | neuropsychological tests |
| Secondary | Digit Span forward and backward | Before TPS sessions, at 1-month follow-up and at 8-months follow-up | neuropsychological tests |
| Secondary | Trail Making Test (TMT), part A and B | Before TPS sessions, at 1-month follow-up and at 8-months follow-up | neuropsychological tests |
| Secondary | Phonemic and semantic verbal fluency | Before TPS sessions, at 1-month follow-up and at 8-months follow-up | neuropsychological tests |
1 to 10 of 12Source ClinicalTrials.gov
See all 12 registered outcomesOutcomes0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
None in this release.
Results by group0
Each measurement the trial posted, group by group, in the words and numbers it posted.
None in this release.
Participant flow0
How many started, completed or left each group, period by period.
None in this release.
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals0
The totals the trial posted for each group.
None in this release.
Papers0
The papers the trial lists on ClinicalTrials.gov.
None in this release.
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests5
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
| Test | Named as | Source |
|---|---|---|
| Complex Figure Copy and Recall | Secondary outcome | ConductCognition |
| Digit Span Test | Secondary outcome | ConductCognition |
| Trail Making Test A | Secondary outcome | ConductCognition |
| Verbal Fluency | Secondary outcome | ConductCognition |
| Verbal Learning | Secondary outcome | ConductCognition |
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT07883148
GET https://conductscience.org/api/trials/v1/NCT07883148/registered