Trial · NCT07883499
Prospective Study Protocol for Multiparametric PCCT Assessment of Early Ventricular Outcomes After CABG
NCT07883499, Recruiting, Xin Lou
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. Prospective Study Protocol for Multiparametric PCCT Assessment of Early Ventricular Outcomes After CABG. Trials, record NCT07883499. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT07883499
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- Prospective Study Protocol for Multiparametric PCCT Assessment of Early Ventricular Outcomes After CABG
- NCT number
- NCT07883499
- Status
- Recruiting
- Enrollment
- 150 participants, estimated
- Lead sponsor
- Xin Lou
- Conditions
- Coronary Artery Bypass Grafting (CABG) Surgery, Coronary Artery Disease
- First posted
- 2026-10-20
- Last updated
- 2026-10-20
Source ClinicalTrials.gov
Registered outcomes10
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Left ventricular end-systolic volume index at 3 months after CABG | Three months after surgery. The proposed window is postoperative day 90 ±14 days and must be confirmed before protocol finalization and ethics approval. | Left ventricular end-systolic volume index at 3 months after coronary artery bypass grafting Left ventricular end-systolic volume index at 3 months after coronary artery bypass grafting |
| Secondary | Inter-reader relative absolute difference in equivalent lumen diameter | Within 7 days after CABG | Equivalent lumen diameter will be measured independently by two readers at matched anatomical locations on each prespecified PCCT reconstruction. The relative absolute difference will be calculated as the absolute difference between readers divided by their mean, multiplied by 100%. Measurements will be summarized per graft and then equally weighted per patient. Results will be compared between the prespecified reconstruction protocols. |
| Secondary | Absolute difference in diameter stenosis between PCCT and quantitative coronary angiography | Before CABG, with PCCT and ICA performed no more than 30 days apart | In the preoperative ICA validation subgroup, diameter stenosis measured by PCCT will be compared with quantitative coronary angiography at matched native coronary artery or previously stented lesions. The absolute difference will be expressed in percentage points. PCCT and ICA examinations will be no more than 30 days apart, with no relevant intervention or acute event between examinations. |
| Secondary | Absolute error of CFD-estimated mean graft flow relative to intraoperative TTFM | Signed difference between CFD-estimated mean graft flow and intraoperative TTFM | For grafts with matched final intraoperative TTFM records, the absolute difference between CFD-estimated mean flow and TTFM-measured mean flow will be calculated in mL/min. Fixed-geometry and dynamic-geometry models will be compared within the same graft. TTFM will remain independent of model fitting. The comparison will account for the different measurement time points. |
| Secondary | Relative change in bypass graft lumen area at 3 months | Within 7 days after CABG and at 3 months after CABG | For grafts patent on the early postoperative examination, lumen area will be measured at matched anatomical locations using comparable reconstruction and cardiac-phase settings. Relative change will be calculated as the 3-month area minus the early postoperative area, divided by the early postoperative area, multiplied by 100%. Newly occluded grafts will be recorded separately rather than excluded without explanation. |
| Secondary | Change in left ventricular myocardial extracellular volume fraction | Before CABG and within 7 days after CABG | Left ventricular myocardial ECV will be calculated from delayed PCCT iodine maps and contemporaneous hematocrit using a standardized myocardial segmentation method. Change will be calculated as postoperative ECV minus preoperative ECV and expressed in percentage points. |
| Secondary | Change in left ventricular late iodine enhancement burden | Before CABG and within 7 days after CABG | LIE burden will be quantified as the percentage of total left ventricular myocardial volume exhibiting late iodine enhancement. Change will be calculated as postoperative LIE burden minus preoperative LIE burden and expressed in percentage points. The same detection and segmentation rules will be used at both examinations. |
| Secondary | Change in left ventricular ejection fraction | Before CABG, within 7 days after CABG, and at 3 months after CABG | LVEF will be measured from full cardiac-cycle PCCT using standardized ventricular segmentation. Change from the preoperative value will be calculated separately for the early postoperative and 3-month examinations and expressed in percentage points. Contemporaneous echocardiography will provide comparison measurements. |
| Secondary | Change in left ventricular global longitudinal strain | Before CABG, within 7 days after CABG, and at 3 months after CABG | Left ventricular GLS will be measured using CT feature tracking with the same software and strain sign convention across examinations. Change from the preoperative value will be calculated separately for the early postoperative and 3-month examinations and expressed in percentage points. |
| Secondary | Change in left ventricular end-diastolic volume index | Before CABG and within 7 days after CABG | Left ventricular end-diastolic volume will be measured from full cardiac-cycle PCCT and divided by body surface area. Change will be calculated as the early postoperative LVEDVi minus the preoperative value and expressed in mL/m². The same segmentation and body surface area calculation rules will be used. |
Source ClinicalTrials.gov
Outcomes0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
None in this release.
Results by group0
Each measurement the trial posted, group by group, in the words and numbers it posted.
None in this release.
Participant flow0
How many started, completed or left each group, period by period.
None in this release.
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals0
The totals the trial posted for each group.
None in this release.
Papers0
The papers the trial lists on ClinicalTrials.gov.
None in this release.
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT07883499
GET https://conductscience.org/api/trials/v1/NCT07883499/registered