Trial · NCT07883720
EXercise-induced PhysioLogical Adaptations In Neurological Disorders
NCT07883720, Not applicable, Recruiting, Brigham and Women's Hospital
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. EXercise-induced PhysioLogical Adaptations In Neurological Disorders. Trials, record NCT07883720. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT07883720
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- EXercise-induced PhysioLogical Adaptations In Neurological Disorders
- NCT number
- NCT07883720
- Status
- Recruiting
- Phases
- Not applicable
- Enrollment
- 240 participants, estimated
- Lead sponsor
- Brigham and Women's Hospital
- Conditions
- Epilepsy, Functional Neurological Disorder, Mild Cognitive Impairment, Dementia, Parkinson Disease, Concussion, Brain, Brain Tumor, Healthy
- Interventions
- Acute Exercise
- First posted
- 2026-10-20
- Last updated
- 2026-10-20
Source ClinicalTrials.gov
Registered outcomes8
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Changes in functional brain network economy measures from pre- to post-exercise | Before exercise (baseline) and immediately after acute exercise (approximately 10 to 20 minutes) in a single study visit | Resting-state functional connectivity and graph theory measures in whole brain, central autonomic network, and default mode network. Assessed before and after an acute bout of exercise using functional magnetic resonance imaging. |
| Primary | Changes in brain metabolites from pre- to post-exercise | Before exercise (baseline) and immediately after acute exercise (approximately 10 to 20 minutes) in a single study visit | Neurochemical and metabolic markers across several brain regions, including N-acetyl aspartate (NAA; neuronal marker), myoinositol (mI; glial marker), glutamate (excitatory neurotransmitter), creatine (Cr; energy marker), choline (Cho; membrane turnover), and lactate. Assessed before and after an acute bout of exercise using magnetic resonance spectroscopy. |
| Primary | Changes in blood-based biomarkers from pre- to post-exercise | Before exercise (baseline) and immediately after acute exercise (approximately 10 to 20 minutes) in a single study visit | Inflammatory and neurotrophic plasma biomarkers assessed before and after an acute bout of exercise using ultrasensitive targeted immunoassays. |
| Primary | Changes in autonomic nervous system activity from pre- to post-exercise | Before exercise (baseline) and immediately after acute exercise (approximately 10 to 20 minutes) in a single study visit | Heart-rate-variability (HRV) and electrodermal activity (EDA) parameters assessed before and after an acute bout of exercise using a wearable wrist sensor. |
| Secondary | Cardiorespiratory Fitness | One-time measurement during acute exercise (approximately 10 to 20 minutes). | Maximal oxygen uptake (relative VO2max) assessed during acute exercise (cardiopulmonary exercise testing). |
| Secondary | Exercise Performance | One-time measurement during acute exercise (approximately 10 to 20 minutes). | Maximal workload (Watt per kilogram body weight) achieved during acute exercise (cardiopulmonary exercise testing). |
| Secondary | Objective exhaustion | One-time measurement during acute exercise (approximately 10 to 20 minutes). | Achievement of predefined objective exhaustion criteria assessed by spirometry and heart rate data during acute exercise (cardiopulmonary exercise testing). |
| Secondary | Subjective exhaustion | One-time measurement during acute exercise (approximately 10 to 20 minutes). | Maximal subjective rating of perceived exertion (RPE) assessed using the Borg scale during acute exercise (cardiopulmonary exercise testing). The Borg scale measures the subjective level of exertion on a scale from 6 (no exertion) to 20 (maximal exertion). |
Source ClinicalTrials.gov
Outcomes0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
None in this release.
Results by group0
Each measurement the trial posted, group by group, in the words and numbers it posted.
None in this release.
Participant flow0
How many started, completed or left each group, period by period.
None in this release.
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals0
The totals the trial posted for each group.
None in this release.
Papers0
The papers the trial lists on ClinicalTrials.gov.
None in this release.
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT07883720
GET https://conductscience.org/api/trials/v1/NCT07883720/registered