Trial · NCT07883772
Prophylactic Ondansetron and Maternal Hemodynamics During Spinal Anesthesia for Elective Cesarean Section
NCT07883772, Not applicable, Completed, Aydin Adnan Menderes University
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. Prophylactic Ondansetron and Maternal Hemodynamics During Spinal Anesthesia for Elective Cesarean Section. Trials, record NCT07883772. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT07883772
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- Prophylactic Ondansetron and Maternal Hemodynamics During Spinal Anesthesia for Elective Cesarean Section
- NCT number
- NCT07883772
- Status
- Completed
- Phases
- Not applicable
- Enrollment
- 66 participants, actual
- Lead sponsor
- Aydin Adnan Menderes University
- Conditions
- Hypotension (MeSH: D007022), Bradycardia
- Interventions
- Ondansetron, Placebo (0.9% sodium chloride)
- First posted
- 2026-10-20
- Last updated
- 2026-10-23
Source ClinicalTrials.gov
Registered outcomes10
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Incidence of maternal hypotension | From spinal anaesthesia to 15 minutes after spinal anaesthesia | Number of participants with hypotension, defined as a decrease in systolic blood pressure to less than 80% of the baseline value. |
| Secondary | Atropine requirement | From spinal anaesthesia to the end of surgery | Number of participants who received intravenous atropine 0.5 mg. |
| Secondary | Incidence of bradycardia | From spinal anaesthesia to 15 minutes after spinal anaesthesia | Number of participants with heart rate below 45 beats/min. |
| Secondary | Total ephedrine dose | From spinal anaesthesia to the end of surgery | Cumulative dose of intravenous ephedrine (mg) administered to treat hypotension. |
| Secondary | Systolic blood pressure | Baseline, during passive leg raising, 1, 5, 8, 12 and 15 minutes after spinal anaesthesia, and after delivery | Systolic blood pressure (mmHg) measured non-invasively. |
| Secondary | Heart rate | Baseline, during passive leg raising, 1, 5, 8, 12 and 15 minutes after spinal anaesthesia, and after delivery | Heart rate (beats/min). |
| Secondary | Perfusion index (PI) | Baseline, during passive leg raising, 1, 5, 8, 12 and 15 minutes after spinal anaesthesia, and after delivery | Perfusion index measured with a Masimo Root monitor using a sensor on the right thumb. |
| Secondary | Pleth variability index (PVI) | Baseline, during passive leg raising, 1, 5, 8, 12 and 15 minutes after spinal anaesthesia, and after delivery | Pleth variability index measured with a Masimo Root monitor using a sensor on the right thumb. |
| Secondary | Ability of PLR-induced changes in PI and PVI to predict post-spinal hypotension | Baseline and during passive leg raising (before spinal anaesthesia) | Area under the receiver operating characteristic curve (AUC) of the change in PI and PVI from baseline to passive leg raising for discriminating participants who developed hypotension. |
| Secondary | Apgar score at 1 and 5 minutes after delivery | 1 and 5 minutes after delivery | Neonatal condition assessed with the Apgar score at 1 and 5 minutes after delivery. The Apgar score evaluates five components (heart rate, respiratory effort, muscle tone, reflex irritability and skin color), each scored from 0 to 2. The total score ranges from a minimum of 0 to a maximum of 10, with higher scores indicating a better outcome. |
Source ClinicalTrials.gov
Outcomes0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
None in this release.
Results by group0
Each measurement the trial posted, group by group, in the words and numbers it posted.
None in this release.
Participant flow0
How many started, completed or left each group, period by period.
None in this release.
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals0
The totals the trial posted for each group.
None in this release.
Papers1
The papers the trial lists on ClinicalTrials.gov.
| PMID | Listed as |
|---|---|
| 22100822 | RESULT |
Source PubMed
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT07883772
GET https://conductscience.org/api/trials/v1/NCT07883772/registered