Trial · NCT07884773
Combination Therapy With Danazol, Prednisolone, and Thalidomide for Thalidomide-Refractory Transfusion-Dependent β-Thalassemia
NCT07884773, Phase 3, Recruiting, Khyber Medical University Peshawar
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. Combination Therapy With Danazol, Prednisolone, and Thalidomide for Thalidomide-Refractory Transfusion-Dependent β-Thalassemia. Trials, record NCT07884773. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT07884773
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- Combination Therapy With Danazol, Prednisolone, and Thalidomide for Thalidomide-Refractory Transfusion-Dependent β-Thalassemia
- NCT number
- NCT07884773
- Status
- Recruiting
- Phases
- Phase 3
- Enrollment
- 172 participants, estimated
- Lead sponsor
- Khyber Medical University Peshawar
- Conditions
- Beta-Thalassemia, Thalassemia
- Interventions
- Thalidomide, Danazol, Prednisolone
- First posted
- 2026-10-21
- Last updated
- 2026-10-21
Source ClinicalTrials.gov
Registered outcomes3
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Transfusion independence | Assessed continuously from randomization through final study visit (Month 9 to 12). | Proportion of participants who remain free from red blood cell transfusion for at least 8 consecutive weeks while maintaining hemoglobin greater than or equal to 9.0 g/dL. |
| Primary | Hemoglobin response | Baseline and Month 6. | Mean change in pre-transfusion hemoglobin (g/dL) from baseline to 6 months. |
| Primary | Safety and tolerability | Assessed at every scheduled visit (Months 1, 3, 6, 9, and final visit). | Incidence and severity of treatment-emergent adverse events, including hepatic toxicity, renal dysfunction, hyperglycemia, peripheral neuropathy, and thromboembolic events, graded according to CTCAE v5.0. Incidence and severity of treatment-emergent adverse events, including hepatic toxicity, renal dysfunction, hyperglycemia, peripheral neuropathy, and thromboembolic events, graded according to CTCAE v5.0. Incidence and severity of treatment-emergent adverse events, including hepatic toxicity, renal dysfunction, hyperglycemia, peripheral neuropathy, and thromboembolic events, graded according to CTCAE v5.0. |
Source ClinicalTrials.gov
Outcomes0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
None in this release.
Results by group0
Each measurement the trial posted, group by group, in the words and numbers it posted.
None in this release.
Participant flow0
How many started, completed or left each group, period by period.
None in this release.
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals0
The totals the trial posted for each group.
None in this release.
Papers12
The papers the trial lists on ClinicalTrials.gov.
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT07884773
GET https://conductscience.org/api/trials/v1/NCT07884773/registered