Trial · NCT07885488
Screening Elderly Adults in Rural Communities for Heart Failure Using an NT-proBNP-Guided Strategy in China (SEARCH-HF)
NCT07885488, Not applicable, Recruiting, Jiangsu Taizhou People's Hospital
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. Screening Elderly Adults in Rural Communities for Heart Failure Using an NT-proBNP-Guided Strategy in China (SEARCH-HF). Trials, record NCT07885488. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT07885488
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- Screening Elderly Adults in Rural Communities for Heart Failure Using an NT-proBNP-Guided Strategy in China (SEARCH-HF)
- NCT number
- NCT07885488
- Status
- Recruiting
- Phases
- Not applicable
- Enrollment
- 2,532 participants, estimated
- Lead sponsor
- Jiangsu Taizhou People's Hospital
- Conditions
- Heart Failure
- Interventions
- Symptom-based heart failure screening, NT-proBNP-guided heart failure screening
- First posted
- 2026-10-21
- Last updated
- 2026-10-21
Source ClinicalTrials.gov
Registered outcomes7
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Primary Outcome of Phase 1: New-incident heart-failure diagnosis | 6 months after baseline | (1) HFrEF - symptomatic cardiac dysfunction with LVEF \< 50%; (2) HFpEF - symptoms of HF with LVEF ≥ 50% and echocardiographic evidence of structural or functional cardiac abnormalities; or (3) hospitalisation with heart failure as a primary cause. |
| Primary | Primary Outcome of Extension Study: Composite cardiovascular outcome | 18 months after baseline | Composite cardiovascular endpoint, including cardiovascular death, non-fatal myocardial infarction, non-fatal stroke, and hospitalization for heart failure. |
| Secondary | Positive rate of heart failure | 6 months | The proportion of participants diagnosed with heart failure among those identified as high-risk by the corresponding screening strategy. |
| Secondary | GDMT medication utilization rate | 6 months | The proportion of patients who are eligible for guideline-directed medical therapy (GDMT) and actually receive GDMT within 12 Months. Single-class prescription rate: Prescription rate for a given GDMT drug class = (number of patients prescribed that drug class) / (number of patients eligible for that drug class) × 100%. At least one GDMT class prescription rate: At least one GDMT prescription rate = (number of patients prescribed at least one GDMT drug class) / (total number of patients eligible for GDMT) × 100%. Quadruple GDMT prescription rate: Quadruple therapy prescription rate = (number of patients simultaneously prescribed ARNI/ACEI/ARB + β-blocker + MRA + SGLT2 inhibitor) / (number of patients eligible for all four drug classes) × 100%. |
| Secondary | Proportion of participants with newly detected asymptomatic heart failure | 6 months | The proportion of participants newly diagnosed with asymptomatic heart failure among enrolled elderly participants at 6 months. Heart failure diagnosis will be determined according to the European Society of Cardiology heart failure diagnostic criteria, including heart failure symptoms/signs assessment, echocardiography findings, and elevated natriuretic peptide levels. |
| Secondary | Health economic evaluation | 6 months | From the perspective of healthcare providers/health system, the study will compare the medical resource utilization and costs related to screening, examinations, referrals, and diagnosis during the implementation of the two HF screening strategies, and evaluate the economic benefits of different screening strategies. |
| Secondary | New-incident heart-failure diagnosis Using different NT-proBNP thresholds | 6 months | The proportion of participants newly diagnosed with heart failure under different NT-proBNP threshold strategies. Different NT-proBNP cutoff values (e.g., 125 pg/mL, 300 pg/mL, and other predefined thresholds) will be evaluated for their ability to identify newly diagnosed heart failure. |
Source ClinicalTrials.gov
Outcomes0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
None in this release.
Results by group0
Each measurement the trial posted, group by group, in the words and numbers it posted.
None in this release.
Participant flow0
How many started, completed or left each group, period by period.
None in this release.
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals0
The totals the trial posted for each group.
None in this release.
Papers3
The papers the trial lists on ClinicalTrials.gov.
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT07885488
GET https://conductscience.org/api/trials/v1/NCT07885488/registered