Trial · NCT07886541

VATS or Intrapleural Enzymatic Therapy for Patients With Empyema.

NCT07886541, Phase 4, Recruiting, Amsterdam UMC

3 sourcestrials-2026-11-12-0.5.0

Cite this record

ConductScience Library. VATS or Intrapleural Enzymatic Therapy for Patients With Empyema. Trials, record NCT07886541. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT07886541

On this page

Trial

As registered on ClinicalTrials.gov, in the graph's capture of the registry.

Title: VATS or Intrapleural Enzymatic Therapy for Patients With Empyema.
NCT number: NCT07886541
Status: Recruiting
Phases: Phase 4
Enrollment: 164 participants, estimated
Lead sponsor: Amsterdam UMC
Conditions: Empyema, Pleural, Pleural Infections
Interventions: VATS group, IET
First posted: 2026-10-21
Last updated: 2026-11-10

Source ClinicalTrials.gov

Registered outcomes14

Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.

List	Outcome	Time frame	Description
Primary	Length of hospital stay	Within the first 30 days after chest tube insertion.	This is defined as the number of days from chest tube insertion to hospital discharge.
Secondary	Duration of chest tube drainage	30 days	Number of days between chest tube insertion and removal of chest tube
Secondary	Delayed discharge days	30 days	The number of hospital days between completion of treatment and actual hospital discharge that are unrelated to the treatment of the parapneumonic pleural infection (e.g. awaiting nursing home placement, rehabilitation facility placement, home care arrangements, or other administrative or logistical delays).
Secondary	Re-intervention rates	30 days	The need for additional drainage procedures or surgery
Secondary	Re-admission rates	30 days	Need for re-admission
Secondary	Morbidity	30 days	Defined as any deviation from the expected clinical course, including complications and (serious) adverse events
Secondary	Mortality	30-day and 1-year mortality	Mortality (30-day and 1-year)
Secondary	Type of antibiotic therapy	Up to 3 months after initiation of antibiotic therapy	Type of antibiotic therapy
Secondary	Duration of antibiotic therapy	Up to 3 months after initiation of antibiotic therapy	Duration of antibiotic therapy (in days)
Secondary	Type of analgesic use	30 days	Type of analgesic use

1 to 10 of 14Source ClinicalTrials.gov

See all 14 registered outcomes

Outcomes0

Each outcome the trial posted results for, in ClinicalTrials.gov's words.

None in this release.

Results by group0

Each measurement the trial posted, group by group, in the words and numbers it posted.

None in this release.

Participant flow0

How many started, completed or left each group, period by period.

None in this release.

Adverse events0

Each adverse event the trial posted, group by group: the participants affected out of those at risk.

None in this release.

Adverse event totals0

The totals the trial posted for each group.

None in this release.

Papers8

The papers the trial lists on ClinicalTrials.gov.

PMID	Listed as	Source
21830966	BACKGROUND	PubMed
26254467	BACKGROUND	PubMed
35716828	BACKGROUND	PubMed
36229045	BACKGROUND	PubMed
37433578	BACKGROUND	PubMed
37820359	BACKGROUND	PubMed
40040906	BACKGROUND	PubMed
41158359	BACKGROUND	PubMed

Grants0

The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.

None in this release.

Trial comparisons0

Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.

None in this release.

Tests0

The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.

None in this release.

Data dates

The day each source was copied for this release.

ClinicalTrials.gov: 2026-11-12; ClinicalTrials.gov
Results, from AACT: 2026-03-23; AACT
NIH grant links: 2026-11-13; NIH RePORTER

Sources 3

ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
ClinicalTrials.govNo license stated
NIH RePORTER's clinical studies and project filesPublic domain

Each source's terms

ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
ClinicalTrials.govnone stated
NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this trial from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/trials/v1/NCT07886541

GET https://conductscience.org/api/trials/v1/NCT07886541/registered

API reference For AI assistants