Trial · NCT07886697
Low-Dose Radiotherapy for Painful Knee Osteoarthritis
NCT07886697, Not applicable, Not yet recruiting, Universidad Rey Juan Carlos
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. Low-Dose Radiotherapy for Painful Knee Osteoarthritis. Trials, record NCT07886697. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT07886697
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- Low-Dose Radiotherapy for Painful Knee Osteoarthritis
- NCT number
- NCT07886697
- Status
- Not yet recruiting
- Phases
- Not applicable
- Enrollment
- 283 participants, estimated
- Lead sponsor
- Universidad Rey Juan Carlos
- Conditions
- Knee Osteoarthritis
- Interventions
- Low-Dose Radiotherapy (LDRT)
- First posted
- 2026-10-21
- Last updated
- 2026-10-21
Source ClinicalTrials.gov
Registered outcomes16
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Change From Baseline in Average Index-Knee Pain Intensity at Day 90 | Baseline and Day 90 (90 ± 14 days after the last radiotherapy fraction) | Average pain intensity in the index knee during the previous 7 days will be assessed using an 11-point Numerical Rating Scale (NRS) ranging from 0 (no pain) to 10 (worst imaginable pain). Change will be calculated as baseline NRS minus Day 90 NRS. Positive values indicate improvement, zero indicates no change, and negative values indicate worsening. |
| Secondary | Change From Baseline in Average Index-Knee Pain Intensity at Day 45 | Baseline and Day 45 (45 ± 7 days after the last radiotherapy fraction) | Average pain intensity in the index knee during the previous 7 days will be assessed using an 11-point Numerical Rating Scale (NRS) ranging from 0 (no pain) to 10 (worst imaginable pain). Change will be calculated as baseline NRS minus Day 45 NRS. Positive values indicate improvement, zero indicates no change, and negative values indicate worsening. |
| Secondary | Change From Baseline in WOMAC Pain Subscale Score | Baseline, Day 45 (45 ± 7 days after the last radiotherapy fraction), and Day 90 (90 ± 14 days after the last radiotherapy fraction) | The WOMAC pain subscale consists of 5 items, each scored from 0 to 4, yielding a total score from 0 to 20. Higher scores indicate greater pain. Change from baseline will be assessed at Day 45 and Day 90. |
| Secondary | Change From Baseline in WOMAC Stiffness Subscale Score | Baseline, Day 45 (45 ± 7 days after the last radiotherapy fraction), and Day 90 (90 ± 14 days after the last radiotherapy fraction) | The WOMAC stiffness subscale consists of 2 items, each scored from 0 to 4, yielding a total score from 0 to 8. Higher scores indicate greater stiffness. Change from baseline will be assessed at Day 45 and Day 90. |
| Secondary | Change From Baseline in WOMAC Physical Function Subscale Score | Baseline, Day 45 (45 ± 7 days after the last radiotherapy fraction), and Day 90 (90 ± 14 days after the last radiotherapy fraction) | The WOMAC physical function subscale consists of 17 items, each scored from 0 to 4, yielding a total score from 0 to 68. Higher scores indicate greater functional limitation. Change from baseline will be assessed at Day 45 and Day 90. |
| Secondary | Change From Baseline in KOOS-PS Score | Baseline, Day 45 (45 ± 7 days after the last radiotherapy fraction), and Day 90 (90 ± 14 days after the last radiotherapy fraction) | The 7-item Knee injury and Osteoarthritis Outcome Score-Physical Function Shortform (KOOS-PS) will be used to assess physical function. The raw score will be transformed to a 0-to-100 Rasch-based score, where 0 indicates no difficulty and 100 indicates extreme difficulty. Change from baseline will be assessed at Day 45 and Day 90. |
| Secondary | Change From Baseline in EQ-5D-3L Health Utility Index | Baseline, Day 45 (45 ± 7 days after the last radiotherapy fraction), and Day 90 (90 ± 14 days after the last radiotherapy fraction) | Health-related quality of life will be assessed using the Spanish EQ-5D-3L. The health utility index will be calculated from the five dimensions using the Spanish value set. Higher index values indicate better health status. Change from baseline will be assessed at Day 45 and Day 90. |
| Secondary | Change From Baseline in EQ VAS Score | Baseline, Day 45 (45 ± 7 days after the last radiotherapy fraction), and Day 90 (90 ± 14 days after the last radiotherapy fraction) | Overall health status will be assessed using the EQ Visual Analogue Scale (EQ VAS), ranging from 0 to 100, where 0 represents the worst imaginable health state and 100 represents the best imaginable health state. Change from baseline will be assessed at Day 45 and Day 90. |
| Secondary | Change From Baseline in Patient Global Assessment of the Index Knee | Baseline, Day 45 (45 ± 7 days after the last radiotherapy fraction), and Day 90 (90 ± 14 days after the last radiotherapy fraction) | Patient Global Assessment (PGA) will evaluate the overall impact of index-knee osteoarthritis during the previous 7 days using a 0-to-100 scale. Participants will answer: "Considering all the ways in which the osteoarthritis of your index knee affects you, how would you rate your knee during the past 7 days?" A score of 0 indicates very well/no impact and 100 indicates very poorly/maximum impact. Change from baseline will be assessed at Day 45 and Day 90. |
| Secondary | Proportion of Participants With at Least a 30% Reduction in NRS Pain Intensity | Day 45 (45 ± 7 days after the last radiotherapy fraction) and Day 90 (90 ± 14 days after the last radiotherapy fraction) | A pain responder will be defined as a participant with at least a 30% reduction from baseline in average index-knee pain intensity measured using the 0-to-10 Numerical Rating Scale (NRS). Percentage reduction will be calculated as \[(baseline NRS - follow-up NRS) / baseline NRS\] × 100. The proportion of participants meeting this criterion will be assessed at Day 45 and Day 90. |
1 to 10 of 16Source ClinicalTrials.gov
See all 16 registered outcomesOutcomes0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
None in this release.
Results by group0
Each measurement the trial posted, group by group, in the words and numbers it posted.
None in this release.
Participant flow0
How many started, completed or left each group, period by period.
None in this release.
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals0
The totals the trial posted for each group.
None in this release.
Papers5
The papers the trial lists on ClinicalTrials.gov.
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT07886697
GET https://conductscience.org/api/trials/v1/NCT07886697/registered