Trial · NCT07886996
AI-Based CT Analysis of Coronary Plaque Evolution
NCT07886996, Not yet recruiting, Zhejiang Hospital
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. AI-Based CT Analysis of Coronary Plaque Evolution. Trials, record NCT07886996. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT07886996
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- AI-Based CT Analysis of Coronary Plaque Evolution
- NCT number
- NCT07886996
- Status
- Not yet recruiting
- Enrollment
- 326 participants, estimated
- Lead sponsor
- Zhejiang Hospital
- Conditions
- Coronary Artery Disease
- First posted
- 2026-10-21
- Last updated
- 2026-10-21
Source ClinicalTrials.gov
Registered outcomes4
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Patient-level definite non-calcified plaque progression discrimination (AUC) | After completion of follow-up CCTA assessment and database lock (approximately 12-36 months after baseline CCTA). | Area under the receiver operating characteristic curve (AUC) with 95% confidence interval for the full-system model predicting definite patient-level progression of non-calcified plaque. Definite progression is annualized change in non-calcified plaque percent atheroma volume greater than +MDC95; non-progression includes stability and definite reduction/regression. AUC will be compared with conventional CCTA models using the DeLong test. |
| Secondary | Prediction of definite non-calcified plaque reduction/regression (AUC and classification metrics) | After completion of follow-up CCTA assessment and database lock (approximately 12-36 months after baseline CCTA). | AUC with 95% confidence interval for predicting definite plaque reduction/regression, with sensitivity, specificity, positive predictive value, negative predictive value, and F1 score. |
| Secondary | Model calibration (Brier score) | After completion of follow-up CCTA assessment and database lock (approximately 12-36 months after baseline CCTA). | The prespecified quantitative outcome is the Brier score for the full-system and conventional CCTA models, with calibration curves and the Hosmer-Lemeshow test reported as supporting calibration assessments. Prespecified subgroup and sensitivity analyses will assess robustness. |
| Secondary | Clinical net benefit (decision-curve analysis) | After completion of follow-up CCTA assessment and database lock (approximately 12-36 months after baseline CCTA). | Clinical net benefit of the full-system and conventional CCTA models will be evaluated using decision-curve analysis across prespecified risk-threshold probabilities. Results will be reported as net benefit at each threshold; prespecified subgroup and sensitivity analyses will assess robustness. |
Source ClinicalTrials.gov
Outcomes0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
None in this release.
Results by group0
Each measurement the trial posted, group by group, in the words and numbers it posted.
None in this release.
Participant flow0
How many started, completed or left each group, period by period.
None in this release.
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals0
The totals the trial posted for each group.
None in this release.
Papers4
The papers the trial lists on ClinicalTrials.gov.
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT07886996
GET https://conductscience.org/api/trials/v1/NCT07886996/registered