Trial · NCT07887204
Antibiotic Resistance Genes in Periodontitis
NCT07887204, Active not recruiting, Istanbul University
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. Antibiotic Resistance Genes in Periodontitis. Trials, record NCT07887204. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT07887204
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- Antibiotic Resistance Genes in Periodontitis
- NCT number
- NCT07887204
- Status
- Active not recruiting
- Enrollment
- 50 participants, actual
- Lead sponsor
- Istanbul University
- Conditions
- Periodontal Disease, Periodontitis, Antibiotic Resistance Genes
- First posted
- 2026-10-21
- Last updated
- 2026-11-05
Source ClinicalTrials.gov
Registered outcomes7
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Richness of antibiotic resistance genes (ARGs) in subgingival plaque | Single time point at baseline (day of subgingival plaque sampling; samples will be stored at -80°C and will be sequenced later) | RG diversity, operationalized as ARG richness (the number of distinct ARGs per sample), assessed by Oxford Nanopore shotgun metagenomic sequencing of pooled subgingival plaque after host DNA depletion. ARGs are annotated using CARD/RGI. To account for differences in bacterial biomass between groups, ARG tables are normalized by rarefaction to an equal bacterial read depth (after host read removal), and sequencing depth and host DNA percentage are reported for each sample. ARG richness is compared between periodontitis patients and periodontally healthy individuals. |
| Secondary | Shannon diversity of antibiotic resistance genes (ARGs) in subgingival plaque | Single time point at baseline (day of subgingival plaque sampling; samples will be stored at -80°C and will be sequenced later) | Alpha diversity of the ARG profile, measured by the Shannon index, from Oxford Nanopore shotgun metagenomic data annotated with CARD/RGI. The index is calculated after rarefaction to an equal bacterial read depth (after host read removal) and compared between periodontitis patients and periodontally healthy individuals. |
| Secondary | Composition and relative abundance of ARGs in subgingival plaque | Single time point at baseline (day of subgingival plaque sampling; samples will be stored at -80°C and will be sequenced later) | ARG relative abundance (normalized read counts, e.g., per Gb of bacterial reads) and beta diversity (PCoA) of ARG profiles, annotated with CARD/RGI and ARGs-OAP, compared between periodontitis and healthy groups. |
| Secondary | Presence, diversity and ARG co-localization of mobile genetic elements (MGEs) | Single time point at baseline (day of subgingival plaque sampling; samples will be stored at -80°C and will be sequenced later) | Plasmids, insertion sequences and integrative conjugative elements identified using PlasmidFinder, ISfinder, ICEberg and MobileElementFinder. Co-localization of MGEs with ARGs on the same long reads or contigs is assessed and compared between groups. |
| Secondary | Horizontal gene transfer (HGT) potential of ARGs and its association with ARG diversity | Single time point at baseline (day of subgingival plaque sampling; samples will be stored at -80°C and will be sequenced later) | HGT potential is estimated from the proportion of ARGs co-localized with MGEs. It is compared between periodontitis and healthy groups, and its association with ARG diversity is evaluated within each group. |
| Secondary | Taxonomic composition and diversity of subgingival microbiota | Single time point at baseline (day of subgingival plaque sampling; samples will be stored at -80°C and will be sequenced later) | Alpha and beta diversity and taxonomic profiles from shotgun metagenomic data, with taxonomic assignment integrated with the Human Oral Microbiome Database (HOMD), compared between periodontitis and healthy groups. |
| Secondary | Correlation between ARG profiles and clinical periodontal parameters | Single time point at baseline (day of subgingival plaque sampling; samples will be stored at -80°C and will be sequenced later) | Correlation of ARG diversity and composition with plaque index (PI), gingival index (GI) and probing pocket depth (PPD), clinical attachment loss (CAL), mobility in periodontitis patients. |
Source ClinicalTrials.gov
Outcomes0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
None in this release.
Results by group0
Each measurement the trial posted, group by group, in the words and numbers it posted.
None in this release.
Participant flow0
How many started, completed or left each group, period by period.
None in this release.
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals0
The totals the trial posted for each group.
None in this release.
Papers2
The papers the trial lists on ClinicalTrials.gov.
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT07887204
GET https://conductscience.org/api/trials/v1/NCT07887204/registered