Trial · NCT07887997
Temporal Interference Stimulation (TI) for Schizophrenia (SCZ)
NCT07887997, Not applicable, Not yet recruiting, Anhui Medical University
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. Temporal Interference Stimulation (TI) for Schizophrenia (SCZ). Trials, record NCT07887997. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT07887997
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- Temporal Interference Stimulation (TI) for Schizophrenia (SCZ)
- NCT number
- NCT07887997
- Status
- Not yet recruiting
- Phases
- Not applicable
- Enrollment
- 100 participants, estimated
- Lead sponsor
- Anhui Medical University
- Conditions
- Schizophrenia
- Interventions
- Active transcranial temporal interference stimulation, Sham transcranial temporal interference stimulation
- First posted
- 2026-10-22
- Last updated
- 2026-10-22
Source ClinicalTrials.gov
Registered outcomes18
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Change From Baseline in Positive and Negative Syndrome Scale (PANSS) Total Score at Day 15 | Baseline (Day 0) and Day 15 | The Positive and Negative Syndrome Scale (PANSS) is a clinician-rated instrument used to assess positive symptoms, negative symptoms, and general psychopathology in schizophrenia. The PANSS total score ranges from 30 to 210, with higher scores indicating greater schizophrenia symptom severity. The primary outcome is the change in PANSS total score from baseline to Day 15, compared between the active TI and sham groups. Change is calculated as the Day 15 total score minus the baseline total score, with negative values indicating improvement. |
| Secondary | Change From Baseline in PANSS Total Score at Days 7 and 45 | Baseline (Day 0), Day 7, and Day 45 | The PANSS total score ranges from 30 to 210, with higher scores indicating greater schizophrenia symptom severity. Change at each visit will be calculated as the visit total score minus the baseline total score. Negative changes indicate improvement. Day 7 and Day 45 will be evaluated separately. |
| Secondary | Change From Baseline in PANSS Positive Subscale Score | Baseline (Day 0), Day 7, Day 15, and Day 45 | The PANSS positive subscale comprises 7 items, each scored from 1 to 7, yielding a total score from 7 to 49. Higher scores indicate more severe positive symptoms. Change at each visit will be calculated as the visit score minus the baseline score; a negative value indicates improvement. |
| Secondary | Change From Baseline in PANSS Negative Subscale Score | Baseline (Day 0), Day 7, Day 15, and Day 45 | The PANSS negative subscale comprises 7 items, each scored from 1 to 7, yielding a total score from 7 to 49. Higher scores indicate more severe negative symptoms. Change at each visit will be calculated as the visit score minus the baseline score; a negative value indicates improvement. |
| Secondary | Change From Baseline in PANSS General Psychopathology Subscale Score | Baseline (Day 0), Day 7, Day 15, and Day 45 | The PANSS general psychopathology subscale comprises 16 items, each scored from 1 to 7, yielding a total score from 16 to 112. Higher scores indicate more severe general psychopathology. Change at each visit will be calculated as the visit score minus the baseline score; a negative value indicates improvement. |
| Secondary | Change From Baseline in Auditory Hallucination Rating Scale (AHRS) Total Score | Baseline (Day 0), Day 7, Day 15, and Day 45 | The AHRS assesses the severity of auditory hallucinations across seven dimensions. As specified in the protocol, the total score ranges from 0 to 41, with higher scores indicating more severe auditory hallucinations. Change at each visit will be calculated as the visit total score minus the baseline total score; a negative value indicates improvement. |
| Secondary | Change From Baseline in 17-Item Hamilton Depression Rating Scale (HAMD-17) Total Score | Baseline (Day 0), Day 7, Day 15, and Day 45 | The HAMD-17 is a 17-item clinician-rated measure of depressive symptom severity. Total scores range from 0 to 52, with higher scores indicating more severe depressive symptoms. Changes from baseline to Days 7, 15, and 45 will be compared between the active TI and sham groups. Change is calculated as the total score at each follow-up visit minus the baseline total score, with negative values indicating improvement. |
| Secondary | Change From Baseline in 14-Item Hamilton Anxiety Rating Scale (HAMA-14) Total Score | Baseline (Day 0), Day 7, Day 15, and Day 45 | The HAMA-14 is a 14-item clinician-rated measure of anxiety symptom severity. Total scores range from 0 to 56, with higher scores indicating more severe anxiety symptoms. Changes from baseline to Days 7, 15, and 45 will be compared between the active TI and sham groups. Change is calculated as the total score at each follow-up visit minus the baseline total score, with negative values indicating improvement. |
| Secondary | Change From Baseline in Insomnia Severity Index (ISI) Total Score | Baseline (Day 0), Day 7, Day 15, and Day 45 | The ISI is a seven-item self-report measure of insomnia severity. Total scores range from 0 to 28, with higher scores indicating more severe insomnia. Changes from baseline to Days 7, 15, and 45 will be compared between the active TI and sham groups. Change is calculated as the total score at each follow-up visit minus the baseline total score, with negative values indicating improvement. |
| Secondary | Change From Baseline in Patient Health Questionnaire-15 (PHQ-15) Total Score | Baseline (Day 0), Day 7, Day 15, and Day 45 | The PHQ-15 is a 15-item self-report measure of somatic symptom burden. Total scores range from 0 to 30, with higher scores indicating greater somatic symptom burden. Changes from baseline to Days 7, 15, and 45 will be compared between the active TI and sham groups. Change is calculated as the total score at each follow-up visit minus the baseline total score, with negative values indicating improvement. |
1 to 10 of 18Source ClinicalTrials.gov
See all 18 registered outcomesOutcomes0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
None in this release.
Results by group0
Each measurement the trial posted, group by group, in the words and numbers it posted.
None in this release.
Participant flow0
How many started, completed or left each group, period by period.
None in this release.
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals0
The totals the trial posted for each group.
None in this release.
Papers0
The papers the trial lists on ClinicalTrials.gov.
None in this release.
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT07887997
GET https://conductscience.org/api/trials/v1/NCT07887997/registered