Trial · NCT07888504
Low-Dose Spironolactone in Hemodialysis Patients With Resistant Hypertension
NCT07888504, Phase 4, Completed, Universitas Sebelas Maret
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. Low-Dose Spironolactone in Hemodialysis Patients With Resistant Hypertension. Trials, record NCT07888504. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT07888504
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- Low-Dose Spironolactone in Hemodialysis Patients With Resistant Hypertension
- NCT number
- NCT07888504
- Status
- Completed
- Phases
- Phase 4
- Enrollment
- 21 participants, actual
- Lead sponsor
- Universitas Sebelas Maret
- Conditions
- Resistant Hypertension, Kidney Failure, Chronic, Hemodialysis
- Interventions
- Spironolactone
- First posted
- 2026-10-22
- Last updated
- 2026-10-22
Source ClinicalTrials.gov
Registered outcomes10
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Change in systolic blood pressure | Baseline and week 6 | Office systolic blood pressure (mmHg). Change = week-6 value minus baseline value. |
| Primary | Change in diastolic blood pressure | Baseline and week 6 | Office diastolic blood pressure (mmHg). Change = week-6 value minus baseline value. |
| Secondary | Change in SDNN | Baseline and week 6 | Standard deviation of normal-to-normal intervals (ms) from short-term heart rate variability recording. Change = week-6 value minus baseline value. |
| Secondary | Change in RMSSD | Baseline and week 6 | Root mean square of successive differences (ms) from short-term heart rate variability recording. Change = week-6 value minus baseline value. |
| Secondary | Change in frequency-domain heart rate variability | Baseline and week 6 | Total power, very-low-frequency power, low-frequency power, high-frequency power (ms\^2), and LF/HF ratio. Change = week-6 value minus baseline value. |
| Secondary | Change in serum interleukin-6 | Baseline and week 6 | Serum interleukin-6 (pg/mL) measured by ELISA. Change = week-6 value minus baseline value. |
| Secondary | Change in serum high-sensitivity C-reactive protein | Baseline and week 6 | Serum hs-CRP (mg/L) measured by particle-enhanced immunoturbidimetric assay. Change = week-6 value minus baseline value. |
| Secondary | Change in serum NT-proBNP | Baseline and week 6 | Serum N-terminal pro-B-type natriuretic peptide (pg/mL) measured by ELISA. Change = week-6 value minus baseline value. |
| Secondary | Change in serum potassium | Baseline and week 6 | Serum potassium (mmol/L), the main safety measure. Change = week-6 value minus baseline value. |
| Secondary | Change in serum urea and creatinine | Baseline and week 6 | Serum urea and creatinine (mg/dL). Change = week-6 value minus baseline value. |
Source ClinicalTrials.gov
Outcomes0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
None in this release.
Results by group0
Each measurement the trial posted, group by group, in the words and numbers it posted.
None in this release.
Participant flow0
How many started, completed or left each group, period by period.
None in this release.
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals0
The totals the trial posted for each group.
None in this release.
Papers0
The papers the trial lists on ClinicalTrials.gov.
None in this release.
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT07888504
GET https://conductscience.org/api/trials/v1/NCT07888504/registered