Trial · NCT07888569
Assessing the Effect of a Proton Pump Inhibitor on the Pharmacokinetics of DZD8586 in Healthy Participants (TAI-SHAN21)
NCT07888569, Phase 1, Recruiting, Dizal Pharmaceuticals
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. Assessing the Effect of a Proton Pump Inhibitor on the Pharmacokinetics of DZD8586 in Healthy Participants (TAI-SHAN21). Trials, record NCT07888569. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT07888569
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- Assessing the Effect of a Proton Pump Inhibitor on the Pharmacokinetics of DZD8586 in Healthy Participants (TAI-SHAN21)
- NCT number
- NCT07888569
- Status
- Recruiting
- Phases
- Phase 1
- Enrollment
- 26 participants, estimated
- Lead sponsor
- Dizal Pharmaceuticals
- Conditions
- Healthy
- Interventions
- DZD8586, Rabeprazole
- First posted
- 2026-10-22
- Last updated
- 2026-11-06
Source ClinicalTrials.gov
Registered outcomes16
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | AUC0-inf of DZD8586 | Up to 120 hours post-dose | area under plasma concentration-time profile from time 0 extrapolated to infinite time for DZD8586 |
| Primary | AUC0-t of DZD8586 | Up to 120 hours post-dose | area under the plasma concentration-time profile from time 0 to the time of the last quantifiable concentration for DZD8586 |
| Primary | Cmax of DZD8586 | Up to 120 hours post-dose | observed maximal plasma DZD8586 concentration |
| Secondary | tmax of DZD8586 and DZ4581 | Up to 120 hours post-dose | time to the plasma maximal concentration for DZD8586 and its metabolite DZ4581 |
| Secondary | CL/F of DZD8586 | Up to 120 hours post-dose | apparent clearance for DZD8586 |
| Secondary | t1/2 of DZD8586 and DZ4581 | Up to 120 hours post-dose | plasma terminal half-life for DZD8586 and its metabolite DZ4581 |
| Secondary | AUC0-inf of DZ4581 | Up to 120 hours post-dose | area under plasma concentration-time profile from time 0 extrapolated to infinite time for DZ4581 |
| Secondary | AUC0-t of DZ4581 | Up to 120 hours post-dose | area under the plasma concentration-time profile from time 0 to the time of the last quantifiable concentration for DZ4581 |
| Secondary | Cmax of DZ4581 | Up to 120 hours post-dose | observed maximal plasma DZ4581 concentration |
| Secondary | AUC ratios of DZ4581 to DZD8586 (MRAUC) | Up to 120 hours post-dose |
1 to 10 of 16Source ClinicalTrials.gov
See all 16 registered outcomesOutcomes0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
None in this release.
Results by group0
Each measurement the trial posted, group by group, in the words and numbers it posted.
None in this release.
Participant flow0
How many started, completed or left each group, period by period.
None in this release.
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals0
The totals the trial posted for each group.
None in this release.
Papers0
The papers the trial lists on ClinicalTrials.gov.
None in this release.
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT07888569
GET https://conductscience.org/api/trials/v1/NCT07888569/registered