Trial · NCT07888595
Registered outcomes12
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
1 to 12 of 12
Download this page as JSON| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | START/REST biological age (transcriptomic tAge and proteomic pAge), in years | 4 weeks | Change from baseline in biological age from the START/REST clocks - transcriptomic age (tAge) by qPCR and proteomic age (pAge) by plasma protein ELISA panel - in treated tissue (skin, hair, saliva, and/or peripheral blood) versus each participant's untreated reference sites and baseline. Reported in years. |
| Secondary | TART/REST transcriptional indices START^U/D (Psi) and REST (Omega), log10 ratio | 4 weeks | Change from baseline in START\^U/D (Psi = log10\[START\_U/START\_D\]) and REST (Omega = log10\[REST/M.T.\]), measured by qPCR in treated tissue versus untreated reference sites and baseline. Unit: log10 ratio. |
| Secondary | Senescence-associated gene expression, 9-gene qPCR panel, relative expression | 4 weeks | Change from baseline in mRNA expression of CDKN2A, CDKN1A, CDKN1B, CXCR2, LTA4H, TIMP1, MMP1, RELA, and RRM2 by qPCR, reported as relative expression (2\^-ddCt), in treated tissue versus untreated reference sites and baseline |
| Secondary | Plasma pro-inflammatory cytokines IL-6 and IL-8 by ELISA, pg/mL | 4 weeks | Change from baseline in plasma interleukin-6 (IL-6) and interleukin-8 (IL-8), measured by ELISA and reported in pg/mL. |
| Secondary | Intracellular metabolites (alpha-ketoglutarate, ATP, NAD+), micromolar | 4 weeks | Change from baseline in intracellular alpha-ketoglutarate, ATP, and NAD+, measured by enzymatic/colorimetric assay and reported in micromolar (uM), in treated tissue versus untreated reference sites and baseline. |
| Secondary | : NAD+/NADH ratio by enzymatic cycling assay | 4 weeks | Change from baseline in the NAD+/NADH ratio, measured by enzymatic cycling assay and reported as a dimensionless ratio |
| Secondary | NF-kB activity (phosphorylated p65) by ELISA, OD at 450 nm | 4 weeks | Change from baseline in NF-kB activity, quantified as cytoplasmic and nuclear phosphorylated p65 by Instant One ELISA (Thermo Scientific) and reported as optical density at 450 nm. |
| Secondary | Senescence-associated beta-galactosidase activity, nM 4-MU equivalents | 4 weeks | Change from baseline in SA-beta-galactosidase activity, measured fluorometrically (excitation 360 nm, emission 465 nm) against a 4-methylumbelliferone (4-MU) standard and reported as nM 4-MU equivalents. |
| Secondary | Oxidative DNA damage (8-OHdG) by ELISA, ng/mL | 4 weeks | Change from baseline in 8-hydroxy-2'-deoxyguanosine (8-OHdG), measured by ELISA and reported in ng/mL |
| Secondary | Reactive oxygen species and proteasome (UPS) activity, relative fluorescence units | 4 weeks | Change from baseline in intracellular reactive oxygen species (DCFDA probe) and ubiquitin-proteasome (UPS) activity (fluorogenic substrate), each measured fluorometrically and reported in relative fluorescence units (RFU). |
| Secondary | Lactic acid by enzymatic assay, mmol/L | 4 weeks | Change from baseline in lactic acid, measured by enzymatic assay and reported in mmol/L. |
| Secondary | TET enzyme activity by activity ELISA, relative activity (AU) | 4 weeks | Change from baseline in ten-eleven translocation (TET) enzyme activity, measured by activity ELISA and reported as relative activity in arbitrary units (AU). |
Source ClinicalTrials.govtrials-2026-11-12-0.5.0
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
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