Trial · NCT07889609
Intra-Abdominal Pressure, Respiratory Mechanics, and Ventilator Liberation After Emergency Major Laparotomy
NCT07889609, Not yet recruiting, Bursa Yuksek Ihtisas Training and Research Hospital
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. Intra-Abdominal Pressure, Respiratory Mechanics, and Ventilator Liberation After Emergency Major Laparotomy. Trials, record NCT07889609. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT07889609
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- Intra-Abdominal Pressure, Respiratory Mechanics, and Ventilator Liberation After Emergency Major Laparotomy
- NCT number
- NCT07889609
- Status
- Not yet recruiting
- Enrollment
- 100 participants, estimated
- Lead sponsor
- Bursa Yuksek Ihtisas Training and Research Hospital
- Conditions
- Intra-Abdominal Hypertension, Respiratory Mechanics, Mechanical Ventilation
- Interventions
- Serial Intra-Abdominal Pressure and Respiratory Mechanics Assessment
- First posted
- 2026-10-22
- Last updated
- 2026-10-26
Source ClinicalTrials.gov
Registered outcomes11
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Association Between Intra-Abdominal Pressure and Static Respiratory System Compliance | From ICU admission through 48 hours after ICU admission | The longitudinal association between intra-abdominal pressure (IAP, mmHg) and static respiratory system compliance (mL/cmH2O) will be evaluated using repeated simultaneous measurements obtained within the first hour after postoperative ICU admission and at 6, 12, 18, 24, 36, and 48 hours. Static respiratory system compliance will be calculated as tidal volume divided by the difference between plateau pressure and total positive end-expiratory pressure (PEEP). Linear mixed-effects models will be used to assess within-patient and between-patient associations between IAP and static respiratory system compliance, accounting for repeated measurements. |
| Primary | Time to Successful Liberation From Invasive Mechanical Ventilation | From ICU admission through day 28 | Time from postoperative ICU admission to successful liberation from invasive mechanical ventilation will be assessed within 28 days. Successful liberation is defined as extubation followed by survival without reintubation for seven consecutive days. The association between IAP trajectories during the first 48 hours and time to successful ventilator liberation will be evaluated using competing-risk regression, with death before successful liberation treated as a competing event. |
| Secondary | Association Between Intra-Abdominal Pressure and Driving Pressure | From ICU admission through 48 hours after ICU admission | The longitudinal association between intra-abdominal pressure (mmHg) and respiratory system driving pressure (cmH2O) will be evaluated using simultaneous repeated measurements. Driving pressure will be calculated as plateau pressure minus total PEEP. Linear mixed-effects models will account for repeated measurements within individual patients. |
| Secondary | Invasive Mechanical Ventilation Requirement on Day 7 | Day 7 after ICU admission | The proportion of participants who remain dependent on invasive mechanical ventilation on day 7 after postoperative ICU admission will be assessed. The association between early IAP measurements and continued ventilation will be investigated. |
| Secondary | Early Extubation Failure | Within 48 hours after extubation, during the 28-day follow-up | The proportion of extubated participants requiring reintubation within 48 hours after extubation will be recorded. |
| Secondary | Ventilator-Free Days Through Day 28 | From ICU admission through day 28 | The number of days alive and free from invasive mechanical ventilation during the first 28 days after postoperative ICU admission will be calculated. |
| Secondary | Total Duration of Invasive Mechanical Ventilation | From ICU admission through day 28 | The cumulative duration of invasive mechanical ventilation will be recorded in hours from postoperative ICU admission, including subsequent invasive ventilation episodes during follow-up. |
| Secondary | Spontaneous Breathing Trial Failure | From ICU admission through day 28 | The proportion of participants experiencing failure of a spontaneous breathing trial (SBT) will be recorded. SBT failure will be determined according to predefined clinical criteria, including respiratory distress, oxygen desaturation, hemodynamic instability, or other signs of intolerance. |
| Secondary | Tracheostomy Requirement | From ICU admission through day 28 | The proportion of participants requiring tracheostomy during postoperative intensive care follow-up will be recorded. |
| Secondary | ICU Mortality Within 28 Days | From ICU admission through day 28 | The proportion of participants who die during their postoperative intensive care unit stay will be recorded. |
1 to 10 of 11Source ClinicalTrials.gov
See all 11 registered outcomesOutcomes0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
None in this release.
Results by group0
Each measurement the trial posted, group by group, in the words and numbers it posted.
None in this release.
Participant flow0
How many started, completed or left each group, period by period.
None in this release.
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals0
The totals the trial posted for each group.
None in this release.
Papers3
The papers the trial lists on ClinicalTrials.gov.
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT07889609
GET https://conductscience.org/api/trials/v1/NCT07889609/registered