Trial · NCT07889674
Lactoferrin Nanohydrogel for Soft And Hard Tissue Healing and Implant Stability in Immediate Implant Placement
NCT07889674, Phase 2, Phase 3, Recruiting, Future University in Egypt
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. Lactoferrin Nanohydrogel for Soft And Hard Tissue Healing and Implant Stability in Immediate Implant Placement. Trials, record NCT07889674. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT07889674
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- Lactoferrin Nanohydrogel for Soft And Hard Tissue Healing and Implant Stability in Immediate Implant Placement
- NCT number
- NCT07889674
- Status
- Recruiting
- Phases
- Phase 2, Phase 3
- Enrollment
- 20 participants, estimated
- Lead sponsor
- Future University in Egypt
- Conditions
- Dental Implant, Wound Healing
- Interventions
- 4% bovine lactoferrin nanohydrogel
- First posted
- 2026-10-22
- Last updated
- 2026-10-27
Source ClinicalTrials.gov
Registered outcomes5
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Change in Peri-Implant Bone Regeneration | Immediately after implant placement and at 3 months postoperatively. | Peri-implant bone changes will be assessed using cone-beam computed tomography (CBCT) immediately after implant placement and at the 3-month follow-up. Radiographic bone fill and grayscale values within a predefined region of interest around the implant will be evaluated using the same imaging and measurement protocol at both time points. Changes from immediately after implant placement to 3 months will be compared between the intervention and control groups. CBCT grayscale values will not be reported as Hounsfield units unless a validated calibration method is used. |
| Primary | Change in Dental Implant Stability | Immediately after implant placement and at 3 months postoperatively. | Dental implant stability will be assessed using the AnyCheck device. Measurements will be recorded immediately after implant placement and at the 3-month follow-up. Implant stability will be reported using the device-generated implant stability value on its defined measurement scale. Changes from baseline to 3 months will be compared between the lactoferrin nanohydrogel and control groups. The full scale name, minimum and maximum values, and interpretation of higher values will follow the device specifications. |
| Primary | Change in Peri-Implant Marginal Bone Level | Immediately after implant placement and at 3 months postoperatively. | Peri-implant marginal bone levels will be assessed using cone-beam computed tomography (CBCT). The distance from the implant platform to the first visible bone-to-implant contact will be measured in millimeters (mm) at the mesial and distal aspects of the implant immediately after implant placement and at the 3-month follow-up. Measurements will be performed using a consistent imaging orientation and measurement protocol. Changes from baseline to 3 months will be compared between the lactoferrin nanohydrogel and control groups. An increase in this distance indicates greater marginal bone loss. |
| Secondary | Postoperative Pain Intensity | Immediately after surgery and at 7 days postoperatively. | Postoperative pain intensity will be assessed using the Visual Analog Scale (VAS), scored from 0 to 10, where 0 indicates no pain and 10 indicates the worst imaginable pain. Higher scores indicate greater pain intensity. Pain scores will be recorded immediately after surgery and at 7 days postoperatively and compared between the lactoferrin nanohydrogel and control groups. |
| Secondary | Soft Tissue Healing Following Immediate Implant Placement | At 7 days after implant placement. | Soft tissue healing will be assessed clinically using the Wound Healing Index (Landry), with scores ranging from 1 to 5. Higher scores indicate better wound healing, while lower scores indicate poorer wound healing. The healing status of the surgical site will be evaluated and recorded, and scores will be compared between the lactoferrin nanohydrogel and control groups. |
Source ClinicalTrials.gov
Outcomes0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
None in this release.
Results by group0
Each measurement the trial posted, group by group, in the words and numbers it posted.
None in this release.
Participant flow0
How many started, completed or left each group, period by period.
None in this release.
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals0
The totals the trial posted for each group.
None in this release.
Papers0
The papers the trial lists on ClinicalTrials.gov.
None in this release.
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT07889674
GET https://conductscience.org/api/trials/v1/NCT07889674/registered