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Trial · NCT07891494

Heated, Humidified High-flow Nasal (HHHFN) Cannula vs Nasal Continuous Positive Airway Pressure in Respiratory Distress in Premature Neonates

NCT07891494, Phase 4, Completed, Pakistan Air Force (PAF) Hospital Islamabad

3 sourcestrials-2026-11-12-0.5.0

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ConductScience Library. Heated, Humidified High-flow Nasal (HHHFN) Cannula vs Nasal Continuous Positive Airway Pressure in Respiratory Distress in Premature Neonates. Trials, record NCT07891494. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT07891494

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Trial

As registered on ClinicalTrials.gov, in the graph's capture of the registry.

Title
Heated, Humidified High-flow Nasal (HHHFN) Cannula vs Nasal Continuous Positive Airway Pressure in Respiratory Distress in Premature Neonates
NCT number
NCT07891494
Status
Completed
Phases
Phase 4
Enrollment
100 participants, actual
Lead sponsor
Pakistan Air Force (PAF) Hospital Islamabad
Conditions
Neonatal Respiratory Distress Syndrome
Interventions
Heated Humidified High-Flow Nasal Cannula therapy, nCPAP
First posted
2026-10-23
Last updated
2026-10-27

Source ClinicalTrials.gov

Registered outcomes1

Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.

ListOutcomeTime frameDescription
PrimaryTreatment Failure72 hours of starting treatment
Efficacy will be assessed on basis of treatment failure. Treatment failure defined as requiring intubation or other non-invasive respiratory support within 72 h of starting intervention. Mechanical ventilation will be considered when 1. Sustained increase in oxygen requirement: FiO2\>0.40 to maintain SpO2 of 90%-94% for more than 2 hour 2. Respiratory acidosis: potential of Hydrogen (pH)≤7.20 and PaCO2\>60 mm Hg 3. Frequent or severe apnea despite drug therapy or respiratory support: two or more apnea events requiring bag-mask ventilation within 24 h

Outcomes0

Each outcome the trial posted results for, in ClinicalTrials.gov's words.

None in this release.

Results by group0

Each measurement the trial posted, group by group, in the words and numbers it posted.

None in this release.

Participant flow0

How many started, completed or left each group, period by period.

None in this release.

Adverse events0

Each adverse event the trial posted, group by group: the participants affected out of those at risk.

None in this release.

Adverse event totals0

The totals the trial posted for each group.

None in this release.

Papers8

The papers the trial lists on ClinicalTrials.gov.

PMIDListed asSource
31628028RESULTPubMed
32809614RESULTPubMed
33174590RESULTPubMed
33686823RESULTPubMed
36340730RESULTPubMed
36863329RESULTPubMed
37481707RESULTPubMed
38036038RESULTPubMed

Grants0

The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.

None in this release.

Trial comparisons0

Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.

None in this release.

Tests0

The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.

None in this release.

Data dates

The day each source was copied for this release.

ClinicalTrials.gov
2026-11-12
ClinicalTrials.gov
Results, from AACT
2026-03-23
AACT
NIH grant links
2026-11-13
NIH RePORTER

Sources 3

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ClinicalTrials.govNo license stated
  • NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ClinicalTrials.govnone stated
  • NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this trial from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/trials/v1/NCT07891494

GET https://conductscience.org/api/trials/v1/NCT07891494/registered