Trial · NCT07891611
Effect of Combined Root Canal Therapies in Mandibular Molars With Coexistent Mature and Immature Apices on the Healing Outcome
NCT07891611, Not applicable, Completed, Al-Azhar University
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. Effect of Combined Root Canal Therapies in Mandibular Molars With Coexistent Mature and Immature Apices on the Healing Outcome. Trials, record NCT07891611. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT07891611
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- Effect of Combined Root Canal Therapies in Mandibular Molars With Coexistent Mature and Immature Apices on the Healing Outcome
- NCT number
- NCT07891611
- Status
- Completed
- Phases
- Not applicable
- Enrollment
- 50 participants, actual
- Lead sponsor
- Al-Azhar University
- Conditions
- Periapical Diseases
- Interventions
- Bioceramic apical plug, Regenerative endodontic procedure
- First posted
- 2026-10-23
- Last updated
- 2026-10-23
Source ClinicalTrials.gov
Registered outcomes8
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Periapical healing assessed by the Periapical Index (PAI) | Baseline, 3, 6 and 12 months after treatment | Periapical status of the treated tooth scored with the Periapical Index (PAI) on digital periapical radiographs at 3, 6 and 12 months, and on cone-beam computed tomography (CBCT) at 12 months. Lower scores indicate healthier periapical status. Reported as the number (%) of teeth in each PAI score category. |
| Secondary | Tenderness to percussion | 3, 6 and 12 months after treatment | Number (%) of teeth with tenderness to percussion. Each tooth was percussed three times on the cusps with the shaft of a straight probe and scored as negative (no pain or discomfort) or positive (pain or discomfort compared with adjacent and contralateral teeth). |
| Secondary | Tenderness to palpation | 3, 6 and 12 months after treatment | Number (%) of teeth with tenderness to palpation, assessed by firm digital pressure over the buccal and lingual cortical plates at the root apices and scored as negative (no tenderness) or positive (tenderness or pain). |
| Secondary | Presence of a sinus tract | 3 and 12 months after treatment | Number (%) of teeth with a sinus tract present on clinical examination. |
| Secondary | Increased tooth mobility | 12 months after treatment | Number (%) of teeth with increased tooth mobility, graded with Miller's classification (grade 0, physiological; grade 1, slight; grade 2, moderate; grade 3, severe). |
| Secondary | Postoperative pain intensity | 24, 48, 72, 96 and 120 hours after treatment | Pain intensity self-reported by patients on a modified Verbal Descriptor Scale (VDS) from 0 (no pain) to 10 (worst pain), using an Arabic-language form. |
| Secondary | Postoperative swelling | 24, 48, 72, 96 and 120 hours after treatment | Swelling self-reported by patients on a four-point scale: 0 = none, 1 = mild intraoral swelling, 2 = moderate localized facial swelling, 3 = severe diffuse facial swelling. |
| Secondary | Pattern of radiographic response of the immature distal root | 12 months after treatment | Radiographic response classified according to Chen et al.: type I, continued root maturation with canal wall thickening; type II, apex becomes blunt and closed without further root development; type III, continued root development with an open apex; type IV, severe canal calcification; type V, hard-tissue barrier formed in the canal. Reported as the number (%) of teeth of each type. |
Source ClinicalTrials.gov
Outcomes0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
None in this release.
Results by group0
Each measurement the trial posted, group by group, in the words and numbers it posted.
None in this release.
Participant flow0
How many started, completed or left each group, period by period.
None in this release.
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals0
The totals the trial posted for each group.
None in this release.
Papers0
The papers the trial lists on ClinicalTrials.gov.
None in this release.
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT07891611
GET https://conductscience.org/api/trials/v1/NCT07891611/registered