Trial · NCT07892313
Inflammatory Biomarkers, Microbial Findings, and Clinical Characteristics Before and After Treatment of Peri-Implant Mucositis Around One-Piece and Two-Piece Dental Implants
NCT07892313, Not applicable, Completed, Cuneyt Asim Aral
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. Inflammatory Biomarkers, Microbial Findings, and Clinical Characteristics Before and After Treatment of Peri-Implant Mucositis Around One-Piece and Two-Piece Dental Implants. Trials, record NCT07892313. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT07892313
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- Inflammatory Biomarkers, Microbial Findings, and Clinical Characteristics Before and After Treatment of Peri-Implant Mucositis Around One-Piece and Two-Piece Dental Implants
- NCT number
- NCT07892313
- Status
- Completed
- Phases
- Not applicable
- Enrollment
- 88 participants, actual
- Lead sponsor
- Cuneyt Asim Aral
- Conditions
One-Piece Dental Implant, Bone-Level Implant, Two-Piece Dental Implant, Nonsurgical Mechanical Debridement, Chlorhexidine Gel, Soft Tissue Phenotype, Peri-Implant Conditions, Peri-Implant Mucositis, Microbiology
- Interventions
- Nonsurgical Mechanical Debridement With 1% Chlorhexidine Gel
- First posted
- 2026-10-23
- Last updated
- 2026-10-23
Source ClinicalTrials.gov
Registered outcomes17
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Change in Peri-Implant Sulcus Fluid Interleukin-1 Beta (IL-1β) Total Amount | Baseline, 1 month, and 3 months after treatment | Total amount of IL-1β in peri-implant sulcus fluid (pg per implant, two pooled paper strips each collected for 30 s), measured by enzyme-linked immunosorbent assay (ELISA). Changes from baseline were compared between one-piece and two-piece bone-level implants with peri-implant mucositis. Baseline values were also compared between implants with peri-implant health and peri-implant mucositis of both designs. |
| Secondary | Change in Peri-Implant Sulcus Fluid Interleukin-10 (IL-10) Total Amount | Baseline, 1 month, and 3 months after treatment | Total amount of IL-10 in peri-implant sulcus fluid (pg per implant, two pooled paper strips each collected for 30 s), measured by ELISA. |
| Secondary | Change in Peri-Implant Sulcus Fluid Matrix Metalloproteinase-8 (MMP-8) Total Amount | Baseline, 1 month, and 3 months after treatment | Total amount of MMP-8 in peri-implant sulcus fluid (ng per implant, two pooled paper strips each collected for 30 s), measured by ELISA. |
| Secondary | Change in Peri-Implant Sulcus Fluid Tissue Inhibitor of Metalloproteinases-1 (TIMP-1) Total Amount | Baseline, 1 month, and 3 months after treatment | Total amount of TIMP-1 in peri-implant sulcus fluid (pg per implant, two pooled paper strips each collected for 30 s), measured by ELISA. |
| Secondary | Change in Peri-Implant Sulcus Fluid IL-1β/IL-10 Ratio | Baseline, 1 month, and 3 months after treatment | Ratio of the total amount of interleukin-1 beta (IL-1β) to the total amount of interleukin-10 (IL-10) in peri-implant sulcus fluid (pg/pg), calculated for each implant from enzyme-linked immunosorbent assay (ELISA) measurements. |
| Secondary | Change in Peri-Implant Sulcus Fluid MMP-8/TIMP-1 Ratio | Baseline, 1 month, and 3 months after treatment | Ratio of the total amount of matrix metalloproteinase-8 (MMP-8, ng) to the total amount of tissue inhibitor of metalloproteinases-1 (TIMP-1, pg) in peri-implant sulcus fluid (ng/pg), calculated for each implant from enzyme-linked immunosorbent assay (ELISA) measurements. |
| Secondary | Change in Plaque Index | Baseline, 1 month, and 3 months after treatment | Plaque index recorded at six sites around the implant and averaged per implant (score 0 to 3, higher scores indicate more plaque). |
| Secondary | Change in Gingival Index | Baseline, 1 month, and 3 months after treatment | Gingival index recorded at six sites around the implant and averaged per implant (score 0 to 3, higher scores indicate more inflammation). |
| Secondary | Change in Probing Depth | Baseline, 1 month, and 3 months after treatment | Probing depth measured at six sites around the implant with a plastic periodontal probe and averaged per implant (mm). |
| Secondary | Change in Bleeding on Probing | Baseline, 1 month, and 3 months after treatment | Percentage of the six sites around the implant showing bleeding within approximately 10 s after gentle probing. |
1 to 10 of 17Source ClinicalTrials.gov
See all 17 registered outcomesOutcomes0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
None in this release.
Results by group0
Each measurement the trial posted, group by group, in the words and numbers it posted.
None in this release.
Participant flow0
How many started, completed or left each group, period by period.
None in this release.
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals0
The totals the trial posted for each group.
None in this release.
Papers10
The papers the trial lists on ClinicalTrials.gov.
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT07892313
GET https://conductscience.org/api/trials/v1/NCT07892313/registered