Trial · NCT07892664
Reducing Arterial Inflammation Using Eplerenone and Statins in HIV
NCT07892664, Phase 2, Phase 3, Not yet recruiting, Massachusetts General Hospital
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. Reducing Arterial Inflammation Using Eplerenone and Statins in HIV. Trials, record NCT07892664. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT07892664
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- Reducing Arterial Inflammation Using Eplerenone and Statins in HIV
- NCT number
- NCT07892664
- Status
- Not yet recruiting
- Phases
- Phase 2, Phase 3
- Enrollment
- 124 participants, estimated
- Lead sponsor
- Massachusetts General Hospital
- Conditions
- HIV (Human Immunodeficiency Virus), Cardiovascular Diseases (CVD), Arterial Inflammation, Heart Disease
- Interventions
- Eplerenone, Placebo
- First posted
- 2026-10-23
- Last updated
- 2026-10-23
Source ClinicalTrials.gov
Registered outcomes7
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Arterial Inflammation | Baseline, 12 Months | Change in target to background ratio (a measure of arterial inflammation) of the index vessel or Change in target to background ratio (a measure of arterial inflammation) of the most diseased segment of the index vessel measured via cardiac positron emission tomography/computed tomography. |
| Secondary | Coronary Inflammation | Baseline, 12 Months | Change in pericoronary adipose tissue density measured via coronary computed tomography angiography |
| Secondary | Systemic Inflammation | Baseline, 12 Months | Change in MCP-1, hsCRP, IL-6, LpPLA2 |
| Secondary | 24 hour Ambulatory Blood Pressure Monitoring | Baseline, 12 Months | Change in blood pressure variability or nocturnal dipping |
| Secondary | Non-Calcified Plaque | Baseline, 12 Months | Change in non-calcified plaque volume measured via coronary computed tomography angiography correlated with change in arterial inflammation as assessed by target to background ratio of the index vessel measured via cardiac positron emission tomography/computed tomography |
| Secondary | High-Risk Plaque Features | Baseline, 12 Months | Change in low Hounsfield Unit attenuation or positive remodeling measured via coronary computed tomography angiography correlated with change in arterial inflammation assessed by target to background ratio of the index vessel measured via cardiac positron emission tomography/computed tomography |
| Secondary | Coronary Inflammation | Baseline, 12 Months | Change in pericoronary adipose tissue density measured via coronary computed tomography angiography correlated with change in non-calcified plaque volume measured via coronary computed tomography angiography |
Source ClinicalTrials.gov
Outcomes0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
None in this release.
Results by group0
Each measurement the trial posted, group by group, in the words and numbers it posted.
None in this release.
Participant flow0
How many started, completed or left each group, period by period.
None in this release.
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals0
The totals the trial posted for each group.
None in this release.
Papers2
The papers the trial lists on ClinicalTrials.gov.
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT07892664
GET https://conductscience.org/api/trials/v1/NCT07892664/registered