Trial · NCT07893353
Mechanisms and Intervention Strategies of Perioperative Glycemic Variability on Postoperative Delirium
NCT07893353, Not applicable, Recruiting, Fujian Medical University Union Hospital
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. Mechanisms and Intervention Strategies of Perioperative Glycemic Variability on Postoperative Delirium. Trials, record NCT07893353. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT07893353
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- Mechanisms and Intervention Strategies of Perioperative Glycemic Variability on Postoperative Delirium
- NCT number
- NCT07893353
- Status
- Recruiting
- Phases
- Not applicable
- Enrollment
- 225 participants, estimated
- Lead sponsor
- Fujian Medical University Union Hospital
- Conditions
- Cardiac Surgery With Cardiopulmonary Bypass, Postoperative Delirium
- Interventions
- Intranasal insulin-20U, Intranasal insulin-40U, Intranasal Saline
- First posted
- 2026-10-23
- Last updated
- 2026-10-23
Source ClinicalTrials.gov
Registered outcomes3
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Number and Proportion of Participants with Postoperative Delirium Assessed Using the Confusion Assessment Method for the Intensive Care Unit (CAM-ICU) Within 7 Days After Surgery | Postoperative days 1 through 7 | Postoperative delirium will be assessed using the Confusion Assessment Method for the Intensive Care Unit (CAM-ICU) during postoperative days 1 through 7. The number and proportion of participants who develop postoperative delirium during this period will be reported. Delirium will be identified according to the CAM-ICU assessment criteria. |
| Secondary | Homeostasis Model Assessment of Insulin Resistance (HOMA-IR) at Baseline, at the End of Cardiopulmonary Bypass, and on Postoperative Days 1, 2, 3, and 7 | Preoperative baseline, at the end of cardiopulmonary bypass, and postoperative days 1, 2, 3, and 7 | Insulin resistance will be assessed using the Homeostasis Model Assessment of Insulin Resistance (HOMA-IR). HOMA-IR will be calculated using blood glucose and insulin concentrations according to the prespecified study protocol. HOMA-IR values will be recorded at the preoperative baseline, at the end of cardiopulmonary bypass (CPB), and on postoperative days 1, 2, 3, and 7. The HOMA-IR values at each assessment time point will be reported. |
| Secondary | Perioperative Glycemic Variability Assessed by Mean Blood Glucose (MBG), Coefficient of Variation (CV), Mean Absolute Glucose Measure, Derived Time in Range (dTIR), and Mean of Daily Differences (MODD) | Preoperative baseline; 15 minutes before anesthesia induction; within the first hour after initiation of CPB; within 10 minutes after termination of CPB; and postoperative days 1 through 3, with four measurements per day at 6-hour intervals. | Perioperative glycemic variability will be evaluated using blood glucose measurements obtained through intermittent sampling at prespecified time points. The assessment parameters will include mean blood glucose (MBG), coefficient of variation (CV), mean absolute glucose measure, derived time in range (dTIR), and mean of daily differences (MODD). Blood glucose measurements will be collected at the following time points: preoperative baseline (fasting blood glucose on hospital admission day 1); 15 minutes before anesthesia induction; within the first hour after initiation of cardiopulmonary bypass (CPB); within 10 minutes after termination of CPB; and four times daily at 6-hour intervals on postoperative days 1 through 3. Each glycemic variability parameter will be calculated according to the prespecified study protocol, and the corresponding values will be reported for the applicable assessment period. |
Source ClinicalTrials.gov
Outcomes0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
None in this release.
Results by group0
Each measurement the trial posted, group by group, in the words and numbers it posted.
None in this release.
Participant flow0
How many started, completed or left each group, period by period.
None in this release.
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals0
The totals the trial posted for each group.
None in this release.
Papers0
The papers the trial lists on ClinicalTrials.gov.
None in this release.
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT07893353
GET https://conductscience.org/api/trials/v1/NCT07893353/registered