Trial · NCT07894185
SMAdult - Monitoring of Movement on Spinal Muscular Atrophy
NCT07894185, Not applicable, Recruiting, Centre Hospitalier Universitaire de Liege
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. SMAdult - Monitoring of Movement on Spinal Muscular Atrophy. Trials, record NCT07894185. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT07894185
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- SMAdult - Monitoring of Movement on Spinal Muscular Atrophy
- NCT number
- NCT07894185
- Status
- Recruiting
- Phases
- Not applicable
- Enrollment
- 60 participants, estimated
- Lead sponsor
- Centre Hospitalier Universitaire de Liege
- Conditions
- Spinal Amyotrophy
- Interventions
- wearable sensors
- First posted
- 2026-10-26
- Last updated
- 2026-10-26
Source ClinicalTrials.gov
Registered outcomes10
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Device usage (recording time) | Recording periods at Baseline, Month 6, Month 12, Month 18, Month 24, Month 30, Month 36 | Total recording time per recording period (hours) |
| Primary | Patient compliance (Min) | Recording periods at Baseline, Month 6, Month 12, Month 18, Month 24, Month 30, Month 36 | Percentage of participants achieving minimal threshold (expected 50h) of recording time per period |
| Primary | Patient compliance (Max) | Recording periods at Baseline, Month 6, Month 12, Month 18, Month 24, month 30, Month 36 | Percentage of participants achieving optimal threshold (expected 180h) of recording time per period |
| Primary | Reliability | Baseline, Month 6, Month 12, Month 18, Month 24, Month 30, Month 36 | Intraclass Correlation Coefficient (ICC) for two distinct consecutive half-periods |
| Secondary | Clinical validity of digital outcome vs functional scale scores. | Day 1, 1 year, 2 years | Correlation between digital outcomes and functional scale scores obtained from the functional assessments available for each patient during follow-up, including the Hammersmith Functional Motor Scale - Expanded (HFMSE; 0-66, higher scores indicate better motor function), Revised Upper Limb Module (RULM; 0-37, higher scores indicate better upper limb function), 4-Stair Climb (4SC; time in seconds, lower times indicate better functional performance), Brooke Upper Extremity Functional Rating Scale (1-6, lower scores indicate better upper limb function), Hammersmith Functional Motor Scale - Short Module (Hammersmith Short Module; \[score range\], higher scores indicate better motor function), and Motor Function Measure - 32 items (MFM-32; 0-96, higher scores indicate better motor function). Only functional scales available for a given patient will be included in the correlation analyses. |
| Secondary | Syde® digital motor outcomes according to SMN2 copy number and patient/control group. | Baseline, Month 6, Month 12, Month 18, Month 24, Month 30, Month 36 | Comparison of digital motor outcomes assessed using the Syde® system between SMA participants with different SMN2 copy numbers and ACTI-CONTROL participants. |
| Secondary | Changes in digital motor outcomes assessed using the Syde® system from baseline to each follow-up assessment. | Baseline, Month 6, Month 12, Month 18, Month 24, Month 30, Month 36 | Change from baseline in digital motor outcome measurements assessed using the Syde® system at Month 6, Month 12, Month 18, Month 24, Month 30 and Month 36. Multiple parameters generated by the Syde® system will be analysed and reported separately, where applicable. |
| Secondary | Longitudinal analysis of digital motor outcomes assessed using the Syde® system. | Baseline, Month 6, Month 12, Month 18, Month 24, Month 30, Month 36 | Analysis of changes in digital motor outcome measurements assessed using the Syde® system across follow-up assessments to characterize disease progression, stabilization, or improvement over time. |
| Secondary | Patient perception of disease progression. | 1 day, 1 year, 2 years | Assessment of patient-perceived disease progression, including changes in mobility, functional capacity, and disease stability, using qualitative interviews and the Patient Global Impression of Change (PGI-C). Results will be compared with digital motor outcomes assessed using the Syde® system to evaluate concordance between patient perceptions and digital biomarkers. |
| Secondary | Qualitative data on swallowing and its association with different genotypes. | 1 day, 1 year, 2 years | DHI or other validated bulbar tests (cf appendix), and correlation with other parameters (genotype and treatment) |
Source ClinicalTrials.gov
Outcomes0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
None in this release.
Results by group0
Each measurement the trial posted, group by group, in the words and numbers it posted.
None in this release.
Participant flow0
How many started, completed or left each group, period by period.
None in this release.
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals0
The totals the trial posted for each group.
None in this release.
Papers0
The papers the trial lists on ClinicalTrials.gov.
None in this release.
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT07894185
GET https://conductscience.org/api/trials/v1/NCT07894185/registered