Trial · NCT07894276
Pain Sensitivity, Alcohol-Induced Analgesia, and Heavy Drinking in Individuals With Opioid Use Disorder
NCT07894276, Early phase 1, Not yet recruiting, Ohio State University
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. Pain Sensitivity, Alcohol-Induced Analgesia, and Heavy Drinking in Individuals With Opioid Use Disorder. Trials, record NCT07894276. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT07894276
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- Pain Sensitivity, Alcohol-Induced Analgesia, and Heavy Drinking in Individuals With Opioid Use Disorder
- NCT number
- NCT07894276
- Status
- Not yet recruiting
- Phases
- Early phase 1
- Enrollment
- 90 participants, estimated
- Lead sponsor
- Ohio State University
- Conditions
- Opioid Use Disorder, Alcohol Intoxication, Pain
- Interventions
- Alcohol, Placebo
- First posted
- 2026-10-26
- Last updated
- 2026-10-26
Source ClinicalTrials.gov
Registered outcomes6
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Pain intensity during the pressure task, measured using a visual analog scale (VAS) | Baseline (Visit 1), approximately 7 days later (Visit 2), and approximately 14 days after baseline (Visit 3) | Pain intensity will be reported during the pressure task administered during each of the three laboratory sessions (Baseline, Placebo, and Alcohol). Participants will rate their perceived pain intensity using a numerical rating scale ranging from 0-100. |
| Primary | Pain pressure threshold during the pressure task | Baseline (Visit 1), approximately 7 days later (Visit 2), and approximately 14 days after baseline (Visit 3) | Pain pressure threshold is estimated by averaging reports across the different runs of the pressure task that is administered at all three lab sessions. |
| Primary | Startle eyeblink potentiation during the anticipation task | Baseline (Visit 1), approximately 7 days later (Visit 2), and approximately 14 days after baseline (Visit 3) | Startle eyeblink potentiation will be collected during the anticipation task that is administered at all three lab sessions. Startle is a cross-species index of aversive reactivity. |
| Primary | Self-reported affect during the anticipation task | Baseline (Visit 1), approximately 7 days later (Visit 2), and approximately 14 days after baseline (Visit 3) | At the end of the anticipation task, participants will rate how intense, arousing, and anxiety-provoking the task was on a 1-to-10 scale, with 1 indicating low intensity, arousal, or anxiety and 10 indicating high intensity, arousal, or anxiety. |
| Primary | Subjective affective response to alcohol in the lab | Placebo and Alcohol sessions (Visits 2 and 3), approximately 7 days apart. | Participants will complete the Profile of Mood States (POMS) throughout the placebo and alcohol administration protocols. The individual mood states will be examined and compared across sessions. Higher scores on each POMS subscale indicate a greater degree of the corresponding mood state, while lower scores indicate a lesser degree of that mood state. |
| Secondary | Subjective effects of alcohol in the lab | Placebo and Alcohol sessions (Visits 2 and 3), approximately 7 days apart. | Participants will rate the degree to which they "feel", "like", and "want more" of the infused substance on a visual analog scale ranging from 0 to 100. The "like" and "want more" scales will serve as the primary measures of alcohol liking and wanting, respectively. |
Source ClinicalTrials.gov
Outcomes0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
None in this release.
Results by group0
Each measurement the trial posted, group by group, in the words and numbers it posted.
None in this release.
Participant flow0
How many started, completed or left each group, period by period.
None in this release.
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals0
The totals the trial posted for each group.
None in this release.
Papers0
The papers the trial lists on ClinicalTrials.gov.
None in this release.
Grants1
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
| Project | Title | Principal investigators | Organization | Funder | Fiscal years |
|---|---|---|---|---|---|
| R21AA032964 | Pain Sensitivity, Alcohol-Induced Analgesia, and Heavy Drinking in Individuals with Opioid Use Disorder | Gorka, Stephanie; Weafer, Jessica J | OHIO STATE UNIVERSITY | NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM | 2026 |
Source NIH RePORTER
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT07894276
GET https://conductscience.org/api/trials/v1/NCT07894276/registered