Trial · NCT07894536
Muscle MRI Fat Fraction Before Surgery to Predict Strength Recovery After Foot-Drop Surgery in Charcot-Marie-Tooth Disease
NCT07894536, Not yet recruiting, Peking University Third Hospital
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. Muscle MRI Fat Fraction Before Surgery to Predict Strength Recovery After Foot-Drop Surgery in Charcot-Marie-Tooth Disease. Trials, record NCT07894536. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT07894536
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- Muscle MRI Fat Fraction Before Surgery to Predict Strength Recovery After Foot-Drop Surgery in Charcot-Marie-Tooth Disease
- NCT number
- NCT07894536
- Status
- Not yet recruiting
- Enrollment
- 100 participants, estimated
- Lead sponsor
- Peking University Third Hospital
- Conditions
- Foot Drop, Charcot-Marie-Tooth Disease Type 1A, Charcot-Marie-Tooth Disease Type 2A, Charcot-Marie-Tooth Disease (CMT)
- Interventions
- Tibialis posterior tendon transfer, Individualized adjunct procedures for cavovarus deformity correction, Ankle-foot orthosis (AFO)
- First posted
- 2026-10-26
- Last updated
- 2026-10-26
Source ClinicalTrials.gov
Registered outcomes20
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Change From Baseline in Maximum Isometric Ankle Dorsiflexion Strength at Each Postoperative Time Point | Baseline (within 1 month before surgery) and 3, 6, 12, 24, 36, 48, and 60 months after surgery | Maximal voluntary isometric dorsiflexion strength (MVIC-DF) of the index ankle, measured with a hand-held dynamometer (make-test of 3-5 s performed three times with the participant seated, the knee flexed to 90 degrees and the ankle in neutral; mean of three trials) and normalized to body weight (N/kg). Change is computed as the postoperative value minus the baseline value. The threshold for a clinically meaningful change is 0.77 N/kg (MDC95). |
| Secondary | 1-Minute Walk Distance (1MWD) at Each Assessment | Baseline (within 1 month before surgery) and at 3, 6, 12, 24, 36, 48, and 60 months after surgery | Distance walked in 1 minute at habitual pace on a level 20-m straight course with usual footwear and orthosis/assistive device, recorded in meters. Higher values indicate better walking endurance. The 1-minute walk test shows good test-retest reliability and strong concurrent validity with the 6-minute walk test. |
| Secondary | 10-Meter Walk Test at Comfortable Speed (10MWT) | Baseline (within 1 month before surgery) and at 3, 6, 12, 24, 36, 48, and 60 months after surgery | Gait speed over the central 10 m of a 14-m walkway with 2-m acceleration and deceleration zones, at self-selected comfortable speed, in meters per second; mean of 2 timed trials, usual assistive device permitted and recorded. Higher values indicate better walking speed. |
| Secondary | Active Ankle Dorsiflexion and Plantarflexion Range of Motion | Baseline (within 1 month before surgery) and at 3, 6, 12, 24, 36, 48, and 60 months after surgery | Active ankle dorsiflexion and plantarflexion arc measured with a universal goniometer using bony landmarks (fibular head, lateral malleolus, base of the fifth metatarsal), in degrees; mean of 3 measurements per direction. Higher dorsiflexion values indicate improved active ankle mobility; plantarflexion is reported descriptively. |
| Secondary | Passive Ankle Dorsiflexion and Plantarflexion Range of Motion | Baseline (within 1 month before surgery) and at 3, 6, 12, 24, 36, 48, and 60 months after surgery | Passive ankle dorsiflexion measured with the knee flexed 45 degrees (soleus component) and with the knee extended (gastrocnemius component); passive plantarflexion measured with the participant prone. Universal goniometer with bony landmarks, in degrees; mean of 3 measurements. Higher dorsiflexion values indicate improved passive ankle mobility. |
| Secondary | Charcot-Marie-Tooth Examination Score Version 2 (CMTESv2) | Baseline (within 1 month before surgery) and at 3, 6, 12, 24, 36, 48, and 60 months after surgery | Composite impairment scale with 7 items scored 0-4: sensory symptoms; motor symptoms of legs and arms; pinprick sensibility with Neurotip; vibration with the Rydel-Seiffer graduated 128-Hz tuning fork at the great toe, medial malleolus and tibial tuberosity; MRC-graded leg strength; arm strength of the first dorsal interosseous or abductor pollicis brevis. Total range 0-28; lower scores indicate less impairment. |
| Secondary | Walk-12 Walking Ability Scale | Baseline (within 1 month before surgery) and at 3, 6, 12, 24, 36, 48, and 60 months after surgery | Patient-reported walking ability during the past month: 12 items rated 0-3 (no difficulty to unable), total 0-36. Higher scores indicate greater perceived walking limitation. |
| Secondary | Foot and Ankle Disability Index (FADI and FADI-Sport) | Baseline (within 1 month before surgery) and at 3, 6, 12, 24, 36, 48, and 60 months after surgery | Foot- and ankle-specific patient-reported function: 26 items (8 pain, 18 function) converted to a percentage of the maximum possible score (0-100); FADI-Sport adds 8 sport-activity items converted the same way. Higher scores indicate better function. |
| Secondary | SF-12 Physical and Mental Component Summary Scores (PCS and MCS) | Baseline (within 1 month before surgery) and at 3, 6, 12, 24, 36, 48, and 60 months after surgery | Generic health-related quality of life from the 12-item Short Form Survey, aggregated into physical (PCS) and mental (MCS) component summary scores, norm-based to a mean of 50 (SD 10); validated Chinese version used. Higher scores indicate better quality of life. |
| Secondary | Foot and Ankle Pain on the Numeric Rating Scale (NRS) | Baseline (within 1 month before surgery) and at 3, 6, 12, 24, 36, 48, and 60 months after surgery | Average foot-ankle pain during the past week rated 0-10 (0 = no pain, 10 = worst imaginable pain) for rest, night and activity, one item each; analyzed as continuous scores. Lower values indicate less pain. |
1 to 10 of 20Source ClinicalTrials.gov
See all 20 registered outcomesOutcomes0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
None in this release.
Results by group0
Each measurement the trial posted, group by group, in the words and numbers it posted.
None in this release.
Participant flow0
How many started, completed or left each group, period by period.
None in this release.
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals0
The totals the trial posted for each group.
None in this release.
Papers0
The papers the trial lists on ClinicalTrials.gov.
None in this release.
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT07894536
GET https://conductscience.org/api/trials/v1/NCT07894536/registered