Trial · NCT07894887
EDIT-401 in Adults Who Require Additional Lowering of Low-Density Lipoprotein Cholesterol (LDL-C)
NCT07894887, Phase 1, Phase 2, Not yet recruiting, Editas Medicine, Inc.
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. EDIT-401 in Adults Who Require Additional Lowering of Low-Density Lipoprotein Cholesterol (LDL-C). Trials, record NCT07894887. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT07894887
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- EDIT-401 in Adults Who Require Additional Lowering of Low-Density Lipoprotein Cholesterol (LDL-C)
- NCT number
- NCT07894887
- Status
- Not yet recruiting
- Phases
- Phase 1, Phase 2
- Enrollment
- 56 participants, estimated
- Lead sponsor
- Editas Medicine, Inc.
- Conditions
- Heterozygous Familial Hypercholesterolemia (HeFH)
- Interventions
- Drug: EDIT-401, Placebo
- First posted
- 2026-10-26
- Last updated
- 2026-10-26
Source ClinicalTrials.gov
Registered outcomes9
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Part 1: Incidence of treatment-emergent adverse events (TEAEs) and serious adverse events (SAEs) | Up to 2 years | |
| Primary | Part 2: Placebo-controlled percent change from baseline in serum LDL-C | Up to day 90 | |
| Secondary | Part 1: Percent change from baseline in serum LDL-C | Up to day 90 | |
| Secondary | Part 2: Incidence of treatment-emergent adverse events (TEAEs) and serious adverse events (SAEs) compared to placebo | Up to 2 year | |
| Secondary | Part 2: Proportion of participants with durable LDL-C lowering | Up to 1 year | |
| Secondary | Part 1 and Part 2: Evaluation of maximum observed concentration (Cmax) | Up to day 30 | |
| Secondary | Part 1 and Part 2: Evaluation of time to maximum observed (tmax) | Up to day 30 | |
| Secondary | Part 1 and Part 2: Evaluation of terminal elimination half-life (t1/2) | Up to day 30 | |
| Secondary | Part 1 and Part 2: Evaluation of volume distribution (Vd) | Up to day 30 |
Source ClinicalTrials.gov
Outcomes0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
None in this release.
Results by group0
Each measurement the trial posted, group by group, in the words and numbers it posted.
None in this release.
Participant flow0
How many started, completed or left each group, period by period.
None in this release.
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals0
The totals the trial posted for each group.
None in this release.
Papers0
The papers the trial lists on ClinicalTrials.gov.
None in this release.
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT07894887
GET https://conductscience.org/api/trials/v1/NCT07894887/registered