Trial · NCT07895303
Pre- and Post-procedure Skin Knowledge Study
NCT07895303, Not applicable, Recruiting, ChinaNorm
3 sourcestrials-2026-11-12-0.5.0
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ConductScience Library. Pre- and Post-procedure Skin Knowledge Study. Trials, record NCT07895303. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT07895303
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Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- Pre- and Post-procedure Skin Knowledge Study
- NCT number
- NCT07895303
- Status
- Recruiting
- Phases
- Not applicable
- Enrollment
- 60 participants, estimated
- Lead sponsor
- ChinaNorm
- Conditions
- Skin Physiology After Fractional CO₂ Laser Treatment, Skin Physiology After Thermage Treatment
- Interventions
- CO₂ fractional laser skin treatment, Thermage skin tightening treatment, Neutral broad-spectrum sunscreen, Neutral moisturizing cream
- First posted
- 2026-10-26
- Last updated
- 2026-10-26
Source ClinicalTrials.gov
Registered outcomes13
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Clinical Grading by Dermatologist for efficacy | T-2w (2 weeks before procedure), T0 (baseline, before procedure), Timm (right after procedure), T5d (5 days after procedure), T10d (10 days after procedure), T28d (28 days after procedure), T56d (56 days after procedure), T84d (84 days after procedure) | A validated dermatologist conducts clinical scoring of facial indicators. Crow's feet wrinkles, under-eye wrinkles, lower facial ptosis and pigment spot density are scored according to the Atlas of Skin Aging Scale. The Atlas of Skin Aging Scale has item-specific score ranges: Crow's feet wrinkles / lower facial ptosis (0 to 6), pigment spot density (0 to 7), under-eye wrinkles (0 to 9); higher scores indicate greater severity of skin aging findings (worse outcome). Assessments are performed in a standard environment with uniform 6500K cool daylight. The same validated dermatologist assesses all subjects starting from T-2w. Any unexpected change of grader or grading environment will be documented as protocol deviation. |
| Secondary | Facial Photos Tracking by ColorFace | T0 (baseline, before procedure), Timm (right after procedure), T5d (5 days after procedure), T10d (10 days after procedure), T28d (28 days after procedure), T56d (56 days after procedure), T84d (84 days after procedure) | Subjects wear hair band, close eyes and cooperate for image-position matching. The same trained technician captures facial images using ColorFace (Newtone, France). Front, left and right facial photos are acquired under standard (STD60), cross polarized (CP), parallel polarized (PP) and UV modalities. Skin tone (L\* Lightness, a\* Redness, b\* Yellowness) and skin gloss (GC value) are analyzed via IPP software; skin evenness (Even/h76') is analyzed by China-norm self-developed software. |
| Secondary | LC-OCT in vivo imaging measurement | 1d (1 day before procedure), T5d (5 days after procedure), T10d (10 days after procedure), T28d (28 days after procedure), T56d (56 days after procedure), T84d (84 days after procedure) | A trained technician performs in vivo LC-OCT imaging measurement with portable probe on one cheek side. Left/right cheek is assigned per subject by randomization table at 1 day before procedure and remains consistent across all visits. Five repeated measurements are performed on the test area at each time point. |
| Secondary | Facial Photos Tracking by E-mirror | T-1d (1 day before procedure), T5d (5 days after procedure), T10d (10 days after procedure), T28d (28 days after procedure), T56d (56 days after procedure), T84d (84 days after procedure) | Subjects wear hair band, close eyes and cooperate for image-position matching. The same trained technician captures facial photos using E-mirror device starting from baseline. |
| Secondary | Skin Firmness (R0, Uf) measured by Cutometer® Dual MPA 580 | T0 (baseline, before procedure), T5d (5 days after procedure), T10d (10 days after procedure), T28d (28 days after procedure), T56d (56 days after procedure), T84d (84 days after procedure) | Based on suction and stretch principle, Cutometer® Dual MPA 580 (Courage \& Khazaka, Germany) applies negative pressure to draw skin into test probe. Non-contact optical system detects skin penetration depth, analyzed via MPA software to calculate skin elastic properties. The same validated technician performs measurements on cheek. Left/right cheek is assigned for each subject by randomization table at T0 and kept consistent across all visits with fixed Cutometer parameters. Two measurements are performed on assigned cheek at each time point. Averaged R0 (Uf, skin firmness) is used for statistical analysis, all curves will be preserved. |
| Secondary | TEWL Measurement by Tewameter® TM 300 | T0 (baseline, before procedure), T5d (5 days after procedure), T10d (10 days after procedure), T28d (28 days after procedure), T56d (56 days after procedure), T84d (84 days after procedure) | Tewameter® TM300 (Courage + Khazaka, Germany) adopts open-chamber design. The probe indirectly detects density gradient of skin water evaporation by two pairs of temperature and relative humidity sensors to assess TEWL continuously without disturbing skin microenvironment, results expressed in g/h/m². The same validated technician performs measurements on cheek . Left/right cheek is assigned for each subject by randomization table at T0 and kept consistent across all visits. Two measurements are performed on assigned cheek at each time point. |
| Secondary | Skin Hydration Measurement by Corneometer CM825 | T0 (baseline, before procedure), T5d (5 days after procedure), T10d (10 days after procedure), T28d (28 days after procedure), T56d (56 days after procedure), T84d (84 days after procedure) | Corneometer CM825 (Courage \& Khazaka, Germany) measures skin moisture content by capacitance method. The capacitance value is proportional to stratum corneum water content under controlled physical and physiological confounders. Measurements are performed on cheek . Left/right cheek is assigned for each subject by randomization table at T0 and kept consistent across all visits. Three measurements (variation\<10%) are performed on test area at each time point. |
| Secondary | Skin Gross Elasticity (R2, Ua/Uf) measured by Cutometer® Dual MPA 580 | T0 (baseline, before procedure), T5d (5 days after procedure), T10d (10 days after procedure), T28d (28 days after procedure), T56d (56 days after procedure), T84d (84 days after procedure) | Based on suction and stretch principle, Cutometer® Dual MPA 580 (Courage \& Khazaka, Germany) applies negative pressure to draw skin into test probe. Non-contact optical system detects skin penetration depth, analyzed via MPA software to calculate skin elastic properties. The same validated technician performs measurements on cheek. Left/right cheek is assigned for each subject by randomization table at T0 and kept consistent across all visits with fixed Cutometer parameters. Two measurements are performed on assigned cheek at each time point. Averaged R2 (Ua/Uf, gross elasticity) is used for statistical analysis, all curves will be preserved. |
| Secondary | Skin Net Elasticity (R5, Ur/Ue) measured by Cutometer® Dual MPA 580 | T0 (baseline, before procedure), T5d (5 days after procedure), T10d (10 days after procedure), T28d (28 days after procedure), T56d (56 days after procedure), T84d (84 days after procedure) | Based on suction and stretch principle, Cutometer® Dual MPA 580 (Courage \& Khazaka, Germany) applies negative pressure to draw skin into test probe. Non-contact optical system detects skin penetration depth, analyzed via MPA software to calculate skin elastic properties. The same validated technician performs measurements on cheek. Left/right cheek is assigned for each subject by randomization table at T0 and kept consistent across all visits with fixed Cutometer parameters. Two measurements are performed on assigned cheek at each time point. Averaged R5 (Ur/Ue, net elasticity) is used for statistical analysis, all curves will be preserved. |
| Secondary | Skin Biological Elasticity (R7, Ur/Uf) measured by Cutometer® Dual MPA 580 | T0 (baseline, before procedure), T5d (5 days after procedure), T10d (10 days after procedure), T28d (28 days after procedure), T56d (56 days after procedure), T84d (84 days after procedure) | Based on suction and stretch principle, Cutometer® Dual MPA 580 (Courage \& Khazaka, Germany) applies negative pressure to draw skin into test probe. Non-contact optical system detects skin penetration depth, analyzed via MPA software to calculate skin elastic properties. The same validated technician performs measurements on cheek. Left/right cheek is assigned for each subject by randomization table at T0 and kept consistent across all visits with fixed Cutometer parameters. Two measurements are performed on assigned cheek at each time point. Averaged R7 (Ur/Uf, biological elasticity) is used for statistical analysis, all curves will be preserved. |
1 to 10 of 13Source ClinicalTrials.gov
See all 13 registered outcomesOutcomes0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
None in this release.
Results by group0
Each measurement the trial posted, group by group, in the words and numbers it posted.
None in this release.
Participant flow0
How many started, completed or left each group, period by period.
None in this release.
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals0
The totals the trial posted for each group.
None in this release.
Papers0
The papers the trial lists on ClinicalTrials.gov.
None in this release.
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT07895303
GET https://conductscience.org/api/trials/v1/NCT07895303/registered