Trial · NCT07895472
Opioid Reduction and Enhanced Recovery in Orthopaedic Surgery (OREOS)-Knee
NCT07895472, Not applicable, Not yet recruiting, McMaster University
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. Opioid Reduction and Enhanced Recovery in Orthopaedic Surgery (OREOS)-Knee. Trials, record NCT07895472. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT07895472
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
- Opioid Reduction and Enhanced Recovery in Orthopaedic Surgery (OREOS)-Knee
- NCT number
- NCT07895472
- Status
- Not yet recruiting
- Phases
- Not applicable
- Enrollment
- 170 participants, estimated
- Lead sponsor
- McMaster University
- Conditions
- Knee Arthroplasty, Total, Partial Knee Arthroplasty, Chronic Pain, Postoperative, Osteoarthritis (OA) of the Knee
- Interventions
- Standard care, Multicomponent opioid reduction and pain management pathway
- First posted
- 2026-10-26
- Last updated
- 2026-10-30
Source ClinicalTrials.gov
Registered outcomes11
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Chronic postsurgical pain | 3 months after surgery | Presence of chronic postsurgical pain (binary) is defined per the definition adopted in International Classification of Diseases version 11; pain develops or increases in intensity after a surgical procedure or a tissue injury, pain persists beyond the healing process (3 months), present either at the surgical/area, or projected onto the innervation area of a nerve, other causes of pain (e.g. pre-existing pain conditions, infection, malignancy) are excluded . |
| Secondary | Moderate-to-severe chronic postsurgical pain | 3, 6, 9, and 12 months after surgery | Presence of chronic postsurgical pain (binary) is defined as per the definition adopted in International Classification of Diseases version 11; mild-to-moderate is defined as pain intensity of ≥4/10 during ambulation over the last week. Pain intensity will be measured on a numeric rating scale of 0-10 where a lower score is better. |
| Secondary | Pain control | Up to 3 months after surgery | Time to achieve good pain control (time-to-event); good pain control will be defined as achieving a state of pain intensity of \<4/10 during ambulation over the past week without the need for daily opioid medication for the operated knee. Pain intensity will be measured on a numeric rating scale of 0-10 where a lower score is better. |
| Secondary | Chronic postsurgical pain | 6, 9, and 12 months after surgery | Presence of chronic postsurgical pain (Binary) is defined per the definition adopted in International Classification of Diseases version 11; pain develops or increases in intensity after a surgical procedure or a tissue injury, pain persists beyond the healing process (3 months), present either at the surgical/area, or projected onto the innervation area of a nerve, other causes of pain (e.g. pre-existing pain conditions, infection, malignancy) are excluded. |
| Secondary | Persistent opioid use | 3, 6, 9, and 12 months after surgery | Presence of persistent opioid use (binary), based on patient reporting indicating the need for daily opioid use that started after surgery or increased after surgery . |
| Secondary | Chronic postsurgical pain intensity | 3, 6, 9, and 12 months after surgery | Average intensity of chronic postsurgical pain (continuous) at rest and with movement. Pain intensity will be measured on a numeric rating scale of 0-10 where 0 is better. |
| Secondary | Satisfaction with pain control | 3, 6, 9, and 12 months after surgery | Satisfaction with pain control (continuous) will be measured using a 0 to 100 scale where a higher score is better satisfaction. |
| Secondary | Knee function | 3, 6, 9, and 12 months after surgery | Using the 12-item Oxford Knee Score (continuous) to assess knee function and pain following a total knee replacement. The score range is 0-48 where a higher score is better function. |
| Secondary | Quality of life | 3, 6, 9, and 12 months after surgery | Measured using Euro-Qol 5 dimensions scale consisting of 5 dimensions, including mobility, self-care, usual activities, pain/discomfort, and anxiety/depression. This will be transformed to a utility score where 0 is death and 1 is full health (continuous). |
| Other | Adverse events | From baseline to 12 months after surgery | Operative and knee-related complications, pain medication related adverse events, readmissions, and all serious adverse events |
1 to 10 of 11Source ClinicalTrials.gov
See all 11 registered outcomesOutcomes0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
None in this release.
Results by group0
Each measurement the trial posted, group by group, in the words and numbers it posted.
None in this release.
Participant flow0
How many started, completed or left each group, period by period.
None in this release.
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals0
The totals the trial posted for each group.
None in this release.
Papers0
The papers the trial lists on ClinicalTrials.gov.
None in this release.
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT07895472
GET https://conductscience.org/api/trials/v1/NCT07895472/registered