Trial · NCT07895706
Linear Accelerator Radiosurgical Anterior Capsulotomy With Task-based fMRI Identification of PERSonalized and PrEdictiVE Biomarkers of REsponse in Treatment-Refractory Obsessive-Compulsive Disorder (PERSEVERE Trial)
NCT07895706, Not applicable, Not yet recruiting, University Hospitals Cleveland Medical Center
3 sourcestrials-2026-11-12-0.5.0
Cite this record
ConductScience Library. Linear Accelerator Radiosurgical Anterior Capsulotomy With Task-based fMRI Identification of PERSonalized and PrEdictiVE Biomarkers of REsponse in Treatment-Refractory Obsessive-Compulsive Disorder (PERSEVERE Trial). Trials, record NCT07895706. Release trials-2026-11-12-0.5.0, 12 Nov 2026. https://conductscience.org/library/trials/NCT07895706
On this page
Trial
As registered on ClinicalTrials.gov, in the graph's capture of the registry.
- Title
Linear Accelerator Radiosurgical Anterior Capsulotomy With Task-based fMRI Identification of PERSonalized and PrEdictiVE Biomarkers of REsponse in Treatment-Refractory Obsessive-Compulsive Disorder (PERSEVERE Trial)
- NCT number
- NCT07895706
- Status
- Not yet recruiting
- Phases
- Not applicable
- Enrollment
- 10 participants, estimated
- Lead sponsor
- University Hospitals Cleveland Medical Center
- Conditions
- Treatment-refractory Obsessive-compulsive Disorder (trOCD)
- Interventions
- Radiosurgical anterior capsulotomy
- First posted
- 2026-10-26
- Last updated
- 2026-10-26
Source ClinicalTrials.gov
Registered outcomes7
Each outcome the trial registered, primary first, in ClinicalTrials.gov's words.
| List | Outcome | Time frame | Description |
|---|---|---|---|
| Primary | Change is Yale-Brown Obsessive Compulsive Scale (Y-BOSC) score | Baseline, 3 months post treatment | Y-BOCS is a standardized form with a 58-item checklist to identify obsessions and compulsions and 10 questions to rate symptom severity, with lower scores indicating minimal or no symptoms. |
| Secondary | Change in Y-BOCS score | Baseline, 6 months, 12 months post treatment | Y-BOCS is a standardized form with a 58-item checklist to identify obsessions and compulsions and 10 questions to rate symptom severity, with lower scores indicating minimal or no symptoms. |
| Secondary | Number of adverse events as measured by medical record review | up to 12 months post treatment | |
| Other | Change in behavioral symptoms as measured by the Hamilton Anxiety Rating Scale (HAM-A) | Baseline, 3 months, 6 months, 12 months | The Hamilton Anxiety Rating Scale (HAM-A) is a 14-item clinician-administered tool used to measure the severity of psychic (mental) and somatic (physical) anxiety. Each item is scored on a scale from 0 to 4, with 0: Not present, 1: Mild, 2: Moderate, 3: Severe, 4: Very severe. |
| Other | Change in behavioral symptoms as measured by the Quick Inventory of Depressive Symptomatology self-report (QIDS-SR) | Baseline, 3 months, 6 months, 12 months | The Quick Inventory of Depressive Symptomatology Self-Report (QIDS-SR16) is a 16-item questionnaire that evaluates the severity of depressive symptoms over the past seven days. With lower scores indicating lower severity of depression. |
| Other | Change in behavioral symptoms as measured by the Clinical Global Impressions Scale (CIG) | Baseline, 3 months, 6 months, 12 months | The Clinical Global Impressions (CGI) scale is a clinician-rated tool used to measure psychiatric illness severity, global improvement, and treatment response. With lower scores indicating lower severity of illness or positive clinical improvement. |
| Other | Change in behavioral symptoms as measured by the Obsessive-Compulsive Inventory-Revised OCI-R | Baseline, 3 months, 6 months, 12 months | The Obsessive-Compulsive Inventory-Revised (OCI-R) is an 18-item self-report questionnaire to access the severity of obsessive-compulsive disorder (OCD). Scored on a Likert scale from 0 to 4, with 0 being not at all, and 4 being Extremely. |
Source ClinicalTrials.gov
Outcomes0
Each outcome the trial posted results for, in ClinicalTrials.gov's words.
None in this release.
Results by group0
Each measurement the trial posted, group by group, in the words and numbers it posted.
None in this release.
Participant flow0
How many started, completed or left each group, period by period.
None in this release.
Adverse events0
Each adverse event the trial posted, group by group: the participants affected out of those at risk.
None in this release.
Adverse event totals0
The totals the trial posted for each group.
None in this release.
Papers0
The papers the trial lists on ClinicalTrials.gov.
None in this release.
Grants0
The grants NIH RePORTER links to the trial, newest funded first: NIH's, and some of AHRQ's, CDC's, FDA's and VA's. Each shows its title, principal investigators, organization and funder in its newest year.
None in this release.
Trial comparisons0
Comparisons of the trial's two groups, calculated by ConductScience from the counts it posted.
None in this release.
Tests0
The ConductCognition tests this trial's registered outcomes name, as ScienceGraph matched them in trial-tests-2026-11-12-0.2.1.
None in this release.
Data dates
The day each source was copied for this release.
Sources 3
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ClinicalTrials.govNo license stated
- NIH RePORTER's clinical studies and project filesPublic domain
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ClinicalTrials.govnone stated
- NIH RePORTER's clinical studies and project filesPublic domain (NIH RePORTER)
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this trial from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/trials/v1/NCT07895706
GET https://conductscience.org/api/trials/v1/NCT07895706/registered